国际口腔医学杂志

国际口腔医学杂志 ›› 2026, Vol. 53 ›› Issue (1): 43-50.doi: 10.7518/gjkq.2026201

• 干细胞专栏 • 上一篇    下一篇

牙髓干细胞在牙槽骨再生中的成骨作用及影响因素

丁成兴1(),李小兰2,杨明理1()   

  1. 1.遵义医科大学基础医学院 遵义 563000
    2.遵义医科大学口腔医学院 遵义 563000
  • 收稿日期:2024-12-04 修回日期:2025-05-23 出版日期:2026-01-01 发布日期:2025-12-31
  • 通讯作者: 杨明理
  • 作者简介:丁成兴，学士，Email：2816105292@qq.com
  • 基金资助:
    遵义市科技计划项目（遵市科合HZ字2020-36）;遵义医科大学2018年度学术新苗培养及创新探索专项项目(黔科合平台人才［2018］5772-043);2023年度贵州省卫生健康委科学技术基金(gzwkj2023-520)

Osteogenic effect and factors that influence dental pulp stem cells in alveolar bone regeneration

Chengxing Ding1(),Xiaolan Li2,Mingli Yang1()   

  1. 1.School of Preclinical Medicine, Zunyi Medical University, Zunyi 563000, China
    2.School of Stomatology, Zunyi Medical University, Zunyi 563000, China
  • Received:2024-12-04 Revised:2025-05-23 Online:2026-01-01 Published:2025-12-31
  • Contact: Mingli Yang
  • Supported by:
    2023 Science and Technology Fund Project of Guizhou Provincial Health Commission(gzwkj2023-520);Project of Zunyi Science and Technology Department (Zunyi Science and Technology Cooperation Project HZ [2020]36);Project of Guizhou Province Science and Technology Department (Guizhou Science and Technology Coo-peration [2018]5772-043)

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摘要：

牙髓干细胞具有自我更新和分化为多种细胞类型的潜力，可将其移植到牙槽骨缺损区域，诱导其分化为成骨细胞，从而促进牙槽骨的再生与重建。本文综述了牙髓干细胞在牙槽骨再生中的成骨能力以及影响其成骨能力的因素，分析了牙髓干细胞应用于临床所面临的问题，旨在为牙髓干细胞修复牙槽骨的基础研究和临床应用提供思路。

关键词: 牙髓干细胞, 牙槽骨, 骨缺损, 骨再生

Abstract:

Dental pulp stem cells (DPSCs) have potential for self-renewal and differentiation into various cell types. They can be transplanted into the defect area of the alveolar bone to induce their differentiation into osteoblasts, thereby promoting the regeneration and reconstruction of the alveolar bone. This study reviews the osteogenic ability of DPSCs in alveolar bone regeneration and the factors that influence their osteogenic ability. The challenges faced in the clinical application of DPSCs are analyzed to provide insights into the basic research and clinical application of DPSCs for repairing the alveolar bone.

Key words: dental pulp stem cell, alveolar bone, bone defect, bone regeneration

中图分类号: 

  • R78

图1

DPSC参与成骨分化的机制及影响因素"

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