国际口腔医学杂志

国际口腔医学杂志 ›› 2024, Vol. 51 ›› Issue (6): 706-712.doi: 10.7518/gjkq.2024099

• 论著 • 上一篇    

全身免疫炎症指数与牙周炎患者分级诊断的相关性研究

陈梦洁1,2(),徐文华1,2,刘青青1,2,康毓聃1,刘蓉1,朱丽雷1,2()   

  1. 1.湖南中医药大学口腔医（学）院 长沙 410208
    2.长沙市口腔医院牙周黏膜科 长沙 410004
  • 收稿日期:2024-02-25 修回日期:2024-06-30 出版日期:2024-11-01 发布日期:2024-11-04
  • 通讯作者: 朱丽雷
  • 作者简介:陈梦洁，医师，硕士，Email：1174052274@qq.com
  • 基金资助:
    湖南省卫生健康委科研计划项目(202208013498);湖南中医药大学本科生科研创新基金(2023BKS141)

Correlation analysis between the systemic immune-inflammatory index and graded diagnosis in patients with perio-dontitis

Mengjie Chen1,2(),Wenhua Xu1,2,Qingqing Liu1,2,Yudan Kang1,Rong Liu1,Lilei Zhu1,2()   

  1. 1.School & Hospital of Stomatology, Hunan University of Chinese Medicine, Changsha 410208, China
    2.Dept. of Perio-dontal Mucosa, Changsha Stomatological Hospital, Changsha 410004, China
  • Received:2024-02-25 Revised:2024-06-30 Online:2024-11-01 Published:2024-11-04
  • Contact: Lilei Zhu
  • Supported by:
    Scientific Research Plan Project of Health Commission of Hunan Province(202208013498);Undergraduate Innovation Scientific Research Project of Hunan University of Chinese Medicine(2023BKS141)

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摘要：

目的 探讨全身免疫炎症指数（SII）与牙周炎分级诊断的相关性。 方法 按照纳入及排除标准，对2023年1—10月于长沙市口腔医院就诊患者进行筛选，共选择263人，分为牙周炎组（131例）和牙周健康组（132例），分析两组间SII、中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）、淋巴细胞与单核细胞比值（LMR）的差异。采用Logistic回归分析法和受试者操作特性曲线（ROC）分析牙周炎的患病相关因素及诊断价值，用Spearman相关分析评估血细胞指标与牙周炎分级的相关性。 结果 与牙周健康组相比，牙周炎组SII、NLR、PLR明显升高，LMR明显降低（P<0.05）。SII、NLR、PLR、LMR均对牙周炎有预测价值，其中SII约登指数最大，价值优于NLR、PLR、LMR。Logistic 回归分析显示SII、NLR与牙周炎有相关性且有统计学意义（P<0.05）。牙周炎组各分级间SII、NLR、PLR、LMR的差异均有统计学意义（P<0.05）。牙周炎分级与SII、NLR、PLR呈正相关，与LMR呈负相关（P<0.05）。 结论 SII与牙周炎分级存在相关性，在临床评估牙周炎进展速度方面可能具有一定的预测价值。

关键词: 牙周炎, 分级, 全身免疫炎症指数

Abstract:

Objective This study aimed to investigate the correlation between the systemic immune-inflammatory index (SII) and the diagnosis of periodontitis grading. Methods According to the inclusion and exclusion criteria, patients who attended Changsha Stomatological Hospital from January to October 2023 were screened and divided into the perio-dontitis group (131 patients) and the periodontal health group (132 patients). The differences in SII, neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and lymphocyte to monocyte ratio (LMR) were analyzed between the two groups. We used Logistic regression analysis and receiver operating characteristic curve to analyze the factors related to the prevalence and diagnostic value of periodontitis. Spearman correlation analysis was conducted to determine the correlation between blood cell indicators and pe-riodontitis grading. Results SII, NLR, and PLR were significantly higher and LMR was significantly lower in the periodontitis group compared with the periodontal health group (P<0.05). SII, NLR, PLR, and LMR all had a predictive value for periodontitis, with SII having the greatest Youden index and a better value than NLR, PLR, and LMR. Logistic regression analysis showed that SII and NLR were significantly correlated with periodontitis. We observed a significant difference in SII, NLR, PLR, and LMR among the grades in the periodontitis group (P<0.05). Periodontitis grading was positively correlated with SII, NLR, and PLR but negatively correlated with LMR. Conclusion We found a correlation between SII and periodontitis grading, which may be of clinical value in the assessment of disease progression rate.

Key words: periodontitis, grading, systemic immune-inflammatory index

中图分类号: 

  • R781.4

图1

骨丧失局部放大测量图A：CEJ至牙槽嵴顶距离；B：CEJ至根尖顶点距离。"

表 1

两组患者初诊时基本情况比较 (xˉ±s)"

测量项目

牙周炎组

（n=131）

牙周健康组

（n=132）

P值
性别（男/女）57/7459/730.846
年龄/岁34.25±6.9133.35±6.670.190
PD/mm3.88±1.701.53±0.17<0.000 1
CAL/mm3.64±1.030.00±0.00<0.000 1
BI/mm2.62±0.501.11±0.28<0.000 1

表 2

两组患者血细胞指标比较"

指标牙周炎组（n=131）牙周健康组（n=132）P值
SII（×109/L）/ M（Q1，Q3）423.19（354.20，560.29）337.71（288.97，382.51）<0.000 1
NLR/xˉ±s2.04±0.741.52±0.34<0.000 1
PLR/xˉ±s131.95±41.77113.70±28.21<0.000 1
LMR/xˉ±s5.69±1.646.66±3.170.001

表 3

SII、NLR、PLR、LMR诊断牙周炎的ROC曲线分析"

指标AUC（95% CI）约登指数截断值灵敏度/%特异度/%P值
SII0.758（0.700，0.815）0.409437.0746.294.7<0.000 1
NLR0.729（0.669，0.789）0.3562.0342.493.1<0.000 1
PLR0.636（0.569，0.703）0.241135.8840.284.0<0.000 1
LMR0.621（0.554，0.689）0.2316.4273.549.60.001

图2

SII、NLR、PLR、LMR诊断牙周炎的ROC曲线"

表 6

牙周炎分级与SII、NLR、PLR、LMR的相关性"

指标r值P值

SII

NLR

PLR

LMR

0.942

0.746

0.600

-0.429

<0.000 1

<0.000 1

<0.000 1

<0.000 1

图3

SII、PLR与牙周炎分级的相关性分析"

图4

LMR、NLR与牙周炎分级的相关性分析"

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