国际口腔医学杂志

国际口腔医学杂志 ›› 2022, Vol. 49 ›› Issue (4): 471-475.doi: 10.7518/gjkq.2022069

• 综述 • 上一篇    下一篇

Nod样受体家族嘌呤结构域3炎症小体在口腔黏膜病中的研究进展

陈思婷(),钟雄,孟文霞()   

  1. 南方医科大学口腔医院黏膜科 广州 510280
  • 收稿日期:2021-10-02 修回日期:2022-02-12 出版日期:2022-07-01 发布日期:2022-06-28
  • 通讯作者: 孟文霞
  • 作者简介:陈思婷，医师，硕士，Email：csiting08@163.com
  • 基金资助:
    国家自然科学基金(81500850)

Research progress on Nod-like receptor protein 3 inflammasome in oral mucosal diseases

Chen Siting(),Zhong Xiong,Meng Wenxia.()   

  1. Dept. of Oral Medicine, Stomatological Hospital, Southern Medical University, Guangzhou 510280, China
  • Received:2021-10-02 Revised:2022-02-12 Online:2022-07-01 Published:2022-06-28
  • Contact: Wenxia. Meng
  • Supported by:
    National Natural Science Foundation of China(81500850)

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摘要：

Nod样受体家族嘌呤结构域3（NLRP3）炎症小体作为一种胞浆大分子蛋白复合物，可识别细菌、病毒等病原体及多种危险信号，在机体免疫系统中抵抗病原体入侵方面发挥重要作用，还可通过活化半胱氨酸天冬氨酸蛋白酶-1（caspase-1）诱导促炎细胞因子白细胞介素-1β（IL-1β）和IL-18释放，引起炎症反应。以往的研究已证实NLRP3炎症小体在自身免疫病和感染性疾病中发挥重要调控作用，如类风湿性关节炎、心血管感染等，然而目前关于NLRP3炎症小体在口腔黏膜病方面的研究尚处于起步阶段。本文结合近年来国内外的相关研究，简要总结NLRP3炎症小体与常见的口腔黏膜病（如口腔扁平苔藓、复发性阿弗他溃疡、自身免疫性大疱类疾病等）相关性的研究进展，为NLRP3炎症小体在口腔黏膜病方面的深入研究及其应用提供参考。

关键词: Nod样受体家族嘌呤结构域3炎症小体, 口腔扁平苔藓, 复发性阿弗他溃疡, 自身免疫性大疱类疾病, Nod样受体家族嘌呤结构域3炎症小体抑制剂

Abstract:

Nod-like receptor protein 3 (NLRP3) inflammasome is a cytoplasmic macromolecular protein complex that recognizes bacteria, viruses, and other pathogens, as well as a variety of danger signals. It plays an important role in the immune system’s resistance to pathogen invasion. NLRP3 inflammasome also induces the release of pro-inflammatory cytokines interleukin-1β (IL-1β) and IL-18 by activating caspase-1, thereby causing an inflammatory response. Previous studies confirmed that NLRP3 inflammasome plays an important regulatory role in autoimmune and infectious diseases, such as rheumatoid arthritis and cardiovascular infections. However, the current research on NLRP3 inflammasome in oral mucosal diseases is still in its infancy. Combined with the related research at home and abroad in recent years, this paper briefly summarizes the research progress on the correlation between NLRP3 inflammasome and common oral mucosa diseases (such as oral lichen planus, recurrent aphthous ulcer, and autoimmune bullous diseases) and provides reference for the further study and application of NLRP3 inflammasome in oral mucosal diseases.

Key words: Nod-like receptor protein 3 inflammasome, oral lichen planus, recurrent aphthous ulcer, autoimmune bullous disease, Nod-like receptor protein 3 inflammasome inhibitor

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  • R 781.5
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