国际口腔医学杂志 ›› 2017, Vol. 44 ›› Issue (4): 452-458.doi: 10.7518/gjkq.2017.04.017
杨春艳, 税艳青
Yang Chunyan, Shui Yanqing
摘要: 单核苷酸多态性(SNP)是指基因组中特异位点单个核苷酸变异形成的遗传标记,慢性牙周炎是发生在牙周支持组织的一种多因素导致的慢性感染性疾病,二者间存在着密切的相关关系,其研究主要集中于在免疫系统识别、清除细菌和组织破坏过程或代谢机制中发挥作用的细胞因子、细胞膜受体、趋化因子和酶等编码基因的多态性等。本文就白细胞介素、肿瘤坏死因子、Fcγ受体、维生素D受体和基质金属蛋白酶五大基因家族SNP与慢性牙周炎易患性相关关系的研究进展作一综述,从SNP的角度寻求慢性牙周炎易患性诊断的依据。
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