国际口腔医学杂志

国际口腔医学杂志 ›› 2026, Vol. 53 ›› Issue (3): 297-307.doi: 10.7518/gjkq.2026121

• 专家笔谈 •    

龋病阻断理论及其相关技术和材料的研究进展

张旭()   

  1. 天津医科大学口腔医学院·口腔医院 天津市口腔软硬组织修复再生重点实验室 天津医科大学口腔研究所 天津 300070
  • 收稿日期:2025-10-15 修回日期:2026-01-10 出版日期:2026-05-01 发布日期:2026-04-24
  • 通讯作者: 张旭
  • 作者简介:张旭，教授，博士研究生导师，国家重点研发计划首席科学家，国际牙医学院Fellow，中华口腔医学会口腔材料学专业委员会常务委员。建立了两性聚电解质仿生矿化体系，提出有机基质自组装与矿化协同进行模式、生物矿化3个“关键事件”及“龋病阻断”概念和技术。相关成果发表于国际材料学和口腔医学期刊。获得国家发明专利11项，转化2项，获得省部级科技奖5项，取得1项二类医疗器械产品注册证，发表1篇专家共识。|张旭，教授，博士，Email：zhxden@126.com
  • 基金资助:
    国家重点研发计划(2022YFC2405900);国家重点研发计划(2022YFC2405902)

Research advances in interrupting dental caries and related technologies and materials

Xu Zhang()   

  1. Tianjin Medical University School and Hospital of Stomatology & Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration, Tianjin Medical University Institute of Stomatology, Tianjin 300070, China
  • Received:2025-10-15 Revised:2026-01-10 Online:2026-05-01 Published:2026-04-24
  • Contact: Xu Zhang
  • Supported by:
    National Key Research and Development Program of China(2022YFC2405900)

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摘要：

龋病是口腔内常见的一种慢性感染性疾病，与全身多种疾病密切相关。龋病阻断理论的提出为早期龋病的治疗和预防提供了全新的思路，新型龋病阻断生物材料应具备主动对抗致龋菌感染、再矿化牙体硬组织、良好渗透性等技术特点，以期在龋病早期阶段阻断疾病的发展并一定程度上修复牙体硬组织缺损。本文综述了龋病阻断理论及其相关技术和材料的研究进展，以期为新型龋病阻断技术及材料的研究提供思路。

关键词: 龋病阻断, 抗菌, 再矿化, 渗透性

Abstract:

Dental caries is a common chronic infectious disease in the oral cavity, and it is closely associated with va-rious systemic diseases. The introduction of the caries prevention theory has provided a new approach for the treatment and prevention of early-stage caries. Novel biomaterials for caries prevention should possess technical characteristics, such as actively combating cariogenic bacterial infections, promoting remineralization of dental hard tissues, and exhibi-ting good permeability, to halt disease progression in the early stages of caries and, to some extent, repair defects in dental hard tissues. In this article, the theory of caries prevention and its related techniques and materials are reviewed to provide insights for the research and development of new technologies and materials for caries prevention.

Key words: interrupting dental caries, antibacterial, remineralization, infiltration

中图分类号: 

  • R781.1

图 1

双平衡动态模型"

图 2

生物膜微生态平衡"

图 3

符合龋病阻断概念的材料"

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