国际口腔医学杂志 ›› 2019, Vol. 46 ›› Issue (5): 558-564.doi: 10.7518/gjkq.2019078
Wei Binbin1,Xiao Miao1,Sun Zhe2,Yi Yuli1()
摘要:
鼻咽癌是头颈部最常见的恶性肿瘤,在我国广东、广西、湖南、江西、福建等省(自治区)流行。在接受放射治疗联合化学治疗后,鼻咽癌患者口腔黏膜炎高发。本文综述了鼻咽癌患者口腔黏膜炎的现状、病因、发生机制,以及预防性干预、药物干预、饮食干预、心理干预、康复锻炼等多方面防治措施的研究进展,旨在为临床医护工作提供参考。
中图分类号:
[1] | Chua MLK, Wee JTS, Hui EP , et al. Nasopharyngeal carcinoma[J]. Lancet, 2016,387(10022):1012-1024. |
[2] | Zhu XX, Yang XJ, Chao YL , et al. The potential effect of oral microbiota in the prediction of mucositis during radiotherapy for nasopharyngeal carcinoma[J]. EBioMedicine, 2017,18:23-31. |
[3] | Wang Y. Evidence-based clinical practice on the interventions for oral mucositis for patients with can- cer receiving treatment [C]. 23rd International Nursing Research Congress, Brisbane, Australia, 30 July- 3 August, 2012. |
[4] | Panahi Y, Saadat A, Shadboorestan A , et al. An updated review of natural products intended to prevent or treat oral mucositis in patients undergoing radio-chemotherapy[J]. Curr Pharm Biotechnol, 2016,17(11):949-961. |
[5] | Tao Z, Gao J, Qian L , et al. Factors associated with acute oral mucosal reaction induced by radiotherapy in head and neck squamous cell carcinoma: a retrospective single-center experience[J]. Medicine (Baltimore), 2017,96(50):e8446. |
[6] | Moslemi D, Nokhandani AM, Otaghsaraei MT , et al. Management of chemo/radiation-induced oral mucositis in patients with head and neck cancer: a review of the current literature[J]. Radiother Oncol, 2016,120(1):13-20. |
[7] | 陈佩娟, 苏艳, 杜真真 , 等. 中晚期鼻咽癌患者调强放疗联合化疗不良反应分析及预防护理对策[J]. 护理学报, 2014,21(2):34-37. |
Chen PJ, Su Y, Du ZZ , et al. Analysis of the adverse reaction and preventive nursing measures of intensity modulated radiotherapy combined with chemotherapy in patients with advanced nasopharyngeal carcinoma[J]. J Nurs, 2014,21(2):34-37. | |
[8] | Riley P, Glenny AM, Worthington HV , et al. Interventions for preventing oral mucositis in patients with cancer receiving treatment: oral cryotherapy[J]. Cochrane Database Syst Rev, 2015, 12: CD011552. |
[9] | Almståhl A, Finizia C, Carlén A , et al. Mucosal microflora in head and neck cancer patients[J]. Int J Dent Hyg, 2018,16(4):459-466. |
[10] | Hou J, Zheng H, Li P , et al. Distinct shifts in the oral microbiota are associated with the progression and aggravation of mucositis during radiotherapy[J]. Radiother Oncol, 2018,129(1):44-51. |
[11] | Li K, Yang L, Xin P , et al. Impact of dose volume parameters and clinical factors on acute radiation oral mucositis for locally advanced nasopharyngeal carcinoma patients treated with concurrent intensity-modulated radiation therapy and chemoradiotherapy[J]. Oral Oncol, 2017,72:32-37. |
[12] | Lalla RV, Bowen J, Barasch A , et al. MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy[J]. Cancer, 2014,120(10):1453-1461. |
[13] | Wu SX, Cui TT, Zhao C , et al. A prospective, randomized, multi-center trial to investigate actovegin in prevention and treatment of acute oral mucositis caused by chemoradiotherapy for nasopharyngeal carcinoma[J]. Radiother Oncol, 2010,97(1):113-118. |
[14] | Daugėlaitė G, Užkuraitytė K, Jagelavičienė E , et al. Prevention and treatment of chemotherapy and radiotherapy induced oral mucositis[J]. Medicina (Kau- nas), 2019,55(2). doi: 10.3390/medicina55020025. |
[15] | Mallick S, Benson R, Rath GK . Radiation induced oral mucositis: a review of current literature on prevention and management[J]. Eur Arch Otorhinolaryngol, 2016,273(9):2285-2293. |
[16] | Kanuga S . Cryotherapy and keratinocyte growth factor may be beneficial in preventing oral mucositis in patients with cancer, and sucralfate is effective in reducing its severity[J]. J Am Dent Assoc, 2013,144(8):928-929. |
[17] | Manzi Nde M , Silveira RC, dos Reis PE. Prophylaxis for mucositis induced by ambulatory chemotherapy: systematic review[J]. J Adv Nurs, 2016,72(4):735-746. |
[18] | 李小琴, 黄菊红, 许丽媚 . 口含生理盐水冰块对鼻咽癌放疗患者口腔黏膜的影响[J]. 齐鲁护理杂志, 2017,23(11):35-37. |
Li XQ, Huang JH, Xu LM . Effects of oral saline ice on oral mucosa of radiotherapy patients with nasopharyngeal carcinoma[J]. J Qilu Nurs, 2017,23(11):35-37. | |
[19] | 顾月 . 口含药物冰块对鼻咽癌放疗患者放射性口腔黏膜炎发生率的影响[D]. 郑州: 郑州大学, 2016. |
Gu Y . Effects of oral ice on the incidence of oral mucositis induced by radiotherapy for patients with nasopharyngeal carcinoma[D]. Zhengzhou: Zheng-zhou University, 2016. | |
[20] | Antunes HS, Herchenhorn D, Small IA , et al. Phase Ⅲ trial of low-level laser therapy to prevent oral mucositis in head and neck cancer patients treated with concurrent chemoradiation[J]. Radiother Oncol, 2013,109(2):297-302. |
[21] | Antunes HS, Schluckebier LF, Herchenhorn D , et al. Cost-effectiveness of low-level laser therapy (LLLT) in head and neck cancer patients receiving concurrent chemoradiation[J]. Oral Oncol, 2016,52:85-90. |
[22] | 唐世芳, 朱蓉, 宋瑰琦 , 等. 氦氖激光对放射性口腔黏膜反应及其所致疼痛的作用[J]. 广东医学, 2014,35(7):1056-1058. |
Tang SF, Zhu R, Song GQ , et al. Effects of He-Ne laser on oral mucosa reaction and pain induced by radiation[J]. Guangdong Med J, 2014,35(7):1056-1058. | |
[23] | Simões A, Benites BM, Benassi C , et al. Antimicrobial photodynamic therapy on treatment of infected radiation-induced oral mucositis: report of two cases[J]. Photodiagnosis Photodyn Ther, 2017,20:18-20. |
[24] | Hong JP, Lee SW, Song SY , et al. Recombinant human epidermal growth factor treatment of radiation-induced severe oral mucositis in patients with head and neck malignancies[J]. Eur J Cancer Care (Engl), 2009,18(6):636-641. |
[25] | Riley P, Glenny AM, Worthington HV , et al. Interventions for preventing oral mucositis in patients with cancer receiving treatment: cytokines and growth factors[J]. Cochrane Database Syst Rev, 2017, 11: CD011990. |
[26] | Liang G, Du W, Ke Q , et al. The effects of recombinant human granulocyte colony-stimulating factor mouthwash on radiotherapy-induced oral mucositis in locally advanced nasopharyngeal carcinoma patients[J]. Adv Clin Exp Med, 2017,26(3):409-413. |
[27] | Guo SP, Wu SG, Zhou J , et al. Transdermal fentanyl for pain due to chemoradiotherapy-induced oral mucositis in nasopharyngeal cancer patients: evaluating efficacy, safety, and improvement in quality of life[J]. Drug Des Devel Ther, 2014,8:497-503. |
[28] | Charbaji N, Rosenthal P, Schäfer-Korting M , et al. Cytoprotective effects of opioids on irradiated oral epithelial cells[J]. Wound Repair Regen, 2013,21(6):883-889. |
[29] | Vayne-Bossert P , Escher M, de Vautibault CG, et al. Effect of topical morphine (mouthwash) on oral pain due to chemotherapy- and/or radiotherapy-induced mucositis: a randomized double-blinded study[J]. J Palliat Med, 2010,13(2):125-128. |
[30] | Cerchietti LC, Navigante AH, Bonomi MR , et al. Effect of topical morphine for mucositis-associated pain following concomitant chemoradiotherapy for head and neck carcinoma[J]. Cancer, 2002,95(10):2230-2236. |
[31] | Zheng B, Zhu X, Liu M , et al. Randomized, double-blind, placebo-controlled trial of Shuanghua Baihe tablets to prevent oral mucositis in patients with nasopharyngeal cancer undergoing chemoradiation therapy[J]. Int J Radiat Oncol Biol Phys, 2018,100(2):418-426. |
[32] | Luo Y, Feng M, Fan Z , et al. Effect of Kangfuxin solution on chemo/radiotherapy-induced mucositis in nasopharyngeal carcinoma patients: a multicenter, prospective randomized phase Ⅲ clinical study[J]. Evid Based Complement Alternat Med, 2016,2016:8692343. |
[33] | Bressan V, Stevanin S, Bianchi M , et al. The effects of swallowing disorders, dysgeusia, oral mucositis and xerostomia on nutritional status, oral intake and weight loss in head and neck cancer patients: a systematic review[J]. Cancer Treat Rev, 2016,45:105-119. |
[34] | Jin T, Li KX, Li PJ , et al. An evaluation of nutrition intervention during radiation therapy in patients with locoregionally advanced nasopharyngeal carcinoma[J]. Oncotarget, 2017,8(48):83723-83733. |
[35] | Zahn KL, Wong G, Bedrick EJ , et al. Relationship of protein and calorie intake to the severity of oral mucositis in patients with head and neck cancer receiving radiation therapy[J]. Head Neck, 2012,34(5):655-662. |
[36] | Li G, Jiang XY, Qiu B , et al. Vicious circle of acute radiation toxicities and weight loss predicts poor prognosis for nasopharyngeal carcinoma patients receiving intensity modulated radiotherapy[J]. J Cancer, 2017,8(5):832-838. |
[37] | 高玉英, 林忠尼, 伍碧琦 . 一位拒绝治疗鼻咽癌末期患者之加护护理经验[J]. 护理杂志, 2009,56(1):96-102. |
Kao YY, Lin JN, Wu PC . Caring for a terminal patient with nasopharyngeal carcinoma in the ICU who refuses treatment: a nurse’s experience[J]. J Nurs, 2009,56(1):96-102. | |
[38] | Lai YH, Chang JT, Keefe FJ , et al. Symptom distress, catastrophic thinking, and hope in nasopharyngeal carcinoma patients[J]. Cancer Nurs, 2003,26(6):485-493. |
[39] | 何爱莲, 惠晓颖, 曹丽 . 自我效能理论在放射性口腔黏膜炎中的应用[J]. 河南医学研究, 2014,23(8):151-153. |
He AL, Hui XY, Cao L . Application of self-efficacy theory in radiation-induced oral mucositis[J]. Henan Med Res, 2014,23(8):151-153. | |
[40] | Wang F, Sun Q, Jiang C , et al. Additional induction chemotherapy to concurrent chemotherapy and intensity-modulated radiotherapy with or without nimotuzumab in first-line treatment for locoregionally advanced nasopharyngeal carcinoma: a propensity score matched analysis[J]. J Cancer, 2018,9(3):594-603. |
[41] | 都孟雅, 陈佩娟 . 头颈部功能锻炼加软木塞法对鼻咽癌病人放疗后生活质量的影响[J]. 护理研究, 2017,31(12):1495-1497. |
Du MY, Chen PJ . Influence of head and neck functional exercise combined with cork on quality of life in patients with nasopharyngeal carcinoma after radiotherapy[J]. Nurs Res, 2017,31(12):1495-1497. | |
[42] | 陈静, 马双, 龚伯雄 , 等. 运动锻炼对鼻咽癌患者生活质量的影响[J]. 实用临床医药杂志, 2018,22(6):44-46. |
Chen J, Ma S, Gong BX , et al. Effect of exercise training on quality of life of patients with nasopharyngeal carcinoma[J]. J Clin Med Prac, 2018,22(6):44-46. | |
[43] | Araújo SN , Luz MH, da Silva GR, et al. Cancer patients with oral mucositis: challenges for nursing care[J]. Rev Lat Am Enfermagem, 2015,23(2):267-274. |
[1] | 刘世一, 陈中, 张素欣. 程序性死亡受体/配体免疫治疗策略在人乳头瘤病毒阳性头颈部鳞状细胞癌中的研究进展[J]. 国际口腔医学杂志, 2024, 51(1): 21-27. |
[2] | 和子慕, 李风兰. 数字化口腔定位支架在头颈部肿瘤放射治疗中的应用现状[J]. 国际口腔医学杂志, 2024, 51(1): 28-35. |
[3] | 傅豫, 何薇, 黄兰. 铁死亡在口腔疾病中的研究进展[J]. 国际口腔医学杂志, 2024, 51(1): 36-44. |
[4] | 韩冲,何东宁,余飞燕,吴东潮. 口腔种植术后疼痛机制及治疗的研究进展[J]. 国际口腔医学杂志, 2024, 51(1): 99-106. |
[5] | 胡佳,王秀清,卢国英,黄晓晶. 再生性牙髓治疗在成人根尖发育不全恒牙应用的研究进展[J]. 国际口腔医学杂志, 2023, 50(6): 686-695. |
[6] | 陆磊,王鑫,康泽标,谢富强. 计算机辅助导航手术在复杂颌面部骨折中的应用新进展[J]. 国际口腔医学杂志, 2023, 50(6): 696-703. |
[7] | 杨冬叶,朱萍,吴淑仪. 舌位的影响因素及临床意义[J]. 国际口腔医学杂志, 2023, 50(6): 723-728. |
[8] | 戢晓,张岚,黄定明. 牙源性与非牙源性上颌窦炎鉴别诊断及其治疗方案的研究进展[J]. 国际口腔医学杂志, 2023, 50(5): 566-572. |
[9] | 赵苑汐,苏勤. 根管再治疗中根管充填物去除辅助技术的应用与发展[J]. 国际口腔医学杂志, 2023, 50(5): 581-586. |
[10] | 宋文鹏,龚蓓文,李聃,曾剑玉,仇玲玲. 机械疗法在正畸治疗中应用的研究进展[J]. 国际口腔医学杂志, 2023, 50(5): 603-612. |
[11] | 刘婷,武秀萍. 唐氏综合征的口腔-颅颌面表征及治疗进展[J]. 国际口腔医学杂志, 2023, 50(5): 618-622. |
[12] | 吴思佳,舒畅,王洋,王媛,邓淑丽,王慧明. 根管内感染控制对年轻恒牙牙髓再生治疗的影响及研究进展[J]. 国际口腔医学杂志, 2023, 50(4): 388-394. |
[13] | 高宇天,苏勤. 酸性氧化电位水在根管治疗中的研究与应用[J]. 国际口腔医学杂志, 2023, 50(4): 401-406. |
[14] | 范琳,孙江. 微针在口腔医学中的应用[J]. 国际口腔医学杂志, 2023, 50(4): 472-478. |
[15] | 陈卓,石冰,李精韬. 唇腭裂患者外鼻生长特征的研究进展[J]. 国际口腔医学杂志, 2023, 50(3): 279-286. |
|