国际口腔医学杂志

国际口腔医学杂志 ›› 2016, Vol. 43 ›› Issue (2): 216-219.doi: 10.7518/gjkq.2016.02.022

• 综述 • 上一篇    下一篇

富血小板血纤蛋白在牙槽嵴位点保存中的应用

廖军,徐普   

  1. 中南大学湘雅医学院附属海口医院?海南省口腔医学中心口腔种植科 海口 570208
  • 收稿日期:2015-05-04 修回日期:2015-10-24 出版日期:2016-03-01 发布日期:2016-03-01
  • 通讯作者: 徐普，教授，博士，Email：hnxupu@163.com
  • 作者简介:廖军，学士，Email：375829950@qq.com
  • 基金资助:
    海南省重点科技计划（ZDXM20120054）

The application of platelet-rich fibrin in alveolar ridge site preservation

Liao Jun, Xu Pu   

  1. Dept. of Implantation, Hainan Provincial Stomatological Center, The Affiliated Haikou Hospital, Xiangya School of Medicine, Central South University, Haikou 570208, China)
  • Received:2015-05-04 Revised:2015-10-24 Online:2016-03-01 Published:2016-03-01

RichHTML

11

PDF (PC)

543

被引次数

8

摘要： 牙齿拔除后，牙槽嵴会有一定程度的吸收并伴有软组织的退缩，致使种植修复效果不理想。富血小板血纤蛋白（PRF）富含的血小板、白细胞、白细胞细胞因子、转化生长因子、血小板衍生生长因子、血管内皮生长因子、成纤维细胞生长因子、胰岛素样生长因子等，可有效地调控与组织再生相关的细胞的增殖、分化和程序性死亡，促进手术位点的血管化，增强术区抗感染能力及促进拔牙创软硬组织的再生。PRF多孔网状的三维空间结构有利于生长因子和氧气的弥散，新生骨组织的爬行替代及新生血管的长入，可为骨组织的血管化提供足够的空间，促进拔牙区软硬组织的再生。PRF取自患者自身血液经离心后制得，制备时间短，操作过程简便，较之富血小板血浆有更好的生物安全性和生物活性。PRF既可以单独应用，也可以联合应用。

关键词: 富血小板血纤蛋白, 牙槽嵴, 位点保存, 牙种植, 富血小板血纤蛋白, 牙槽嵴, 位点保存, 牙种植

Abstract: After tooth extraction, there would be some degree of alveolar bone crest absorption with soft tissue recession, which leads to unsatisfactory implantation restoration. Platelet-rich fibrin(PRF) contains platelet, leukocyte, cytokines, transforming growth factor, platelet-derived growth factor, vascular endothelial growth factor, fibroblast growth factor, insulin-like growth factor, et al. These cells and factors could regulate the proliferation, differentiation, and programmeddeath of cells effectively, which are related to tissue regeneration. PRF could promote vascularization in operation site, enhance infected resistance, and promote the regeneration of soft and hard tissue. The porous and reticulated structureof PRF makes it easy for growth factors and oxygen to diffuse, and for new bone forming to replace blood vessels. Itprovides enough space for the vascularization of bone, which promotes the regeneration of soft and hard tissue eventually. Compared with platelet-rich plasma, PRF is acquired from the patients themselves, need less time to prepare, and have better biosecurity and bioactivity. It could work alone, and cooperate with other materials as well.

Key words: platelet-rich fibrin, alveolar ridge, site preservation, dental implantation, platelet-rich fibrin, alveolar ridge, site preservation, dental implantation

中图分类号: 

  • Q 51
[1] 黄弘, 刘鹏, 李晓东, 等. 下颌正中管的锥形束CT成像研究[J]. 华西口腔医学杂志, 2013, 31(5):479-482. Huang H, Liu P, Li XD, et al. Mandibular incisive canal by cone beam CT[J]. West China J Stomatol, 2013, 31(5):479-482.
[2] Araújo MG, Lindhe J. Ridge alterations following tooth extraction with and without flap elevation: an experimental study in the dog[J]. Clin Oral Implants Res, 2009, 20(6):545-549.
[3] Choukroun J, Adda F, Schoeffler C, et al. Une opportunitéen paro-implantologie: le PRF[J]. Implantodontie, 2001, 42:55-62.
[4] Dohan DM, Choukroun J, Diss A, et al. Platelet-rich fibrin(PRF): A second-generation platelet concentrate. PartⅡ: platelet-related biologic features[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2006, 101(3):e45–e50.
[5] Dohan Ehrenfest DM, de Peppo GM, Doglioli P, et al. Slow release of growth factors and thrombospondin-1 in Choukroun’s platelet-rich fibrin(PRF): a gold standard to achieve for all surgical platelet concentrates technologies[J]. Growth Factors, 2009, 27(1):63-69.
[6] 杨世茂, 王明国, 李静, 等. 富血小板纤维蛋白与富血小板血浆体外释放生长因子的比较及其对脂肪干细胞增殖分化的影响[J]. 华西口腔医学杂志, 2012, 30(6):641-644.
Yang SM, Wang MG, Li J, et al. The comparison of platelet-rich fibrin and platelet-rich plasma in releasing of growth factors and their effects on the proliferation and differentiation of adipose tissuederived stem cells in vitro[J]. West China J Stomatol, 2012, 30(6):641-644.
[7] Dohan DM, Choukroun J, Diss A, et al. Platelet-rich fibrin(PRF): a second-generation platelet concentrate. Part Ⅲ: leucocyte activation: a new feature for platelet concentrates[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2006, 101(3):e51-e55.
[8] Lee JW, Kim SG, Kim JY, et al. Restoration of a peri-implant defect by platelet-rich fibrin[J]. Oral Surg Oral Med Oral Pathol Oral Radiol, 2012, 113(4):459-463.
[9] Okuda K, Kawase T, Momose M, et al. Platelet-rich plasma contains high levels of platelet-derived growth factor and transforming growth factor-beta and modulates the proliferation of periodontally related cells in vitro[J]. J Periodontol, 2003, 74(6):849-857.
[10] Marrelli M, Tatullo M. Influence of PRF in the healing of bone and gingival tissues. Clinical and histological evaluations[J]. Eur Rev Med Pharmacol Sci, 2013, 17(14):1958-1962.
[11] Peck MT, Marnewick J, Stephen L. Alveolar ridge preservation using leukocyte and platelet-rich fibrin: a report of a case[J]. Case Rep Dent, 2011, 2011:345048.
[12] Wagner W, Wehrmann M. Differential cytokine activity and morphology during wound healing in the neonatal and adult rat skin[J]. J Cell Mol Med, 11(6):1342-1351.
[13] Border WA, Noble NA. Transforming growth factor beta in tissue fibrosis[J]. N Engl J Med, 1994, 331(19):1286-1292.
[14] Lucarelli E, Beccheroni A, Donati D, et al. Plateletderived growth factors enhance proliferation of human stromal stem cells[J]. Biomaterials, 2003, 24(18):3095-3100.
[15] Heldin CH. Simultaneous induction of stimulatory and inhibitory signals by PDGF[J]. FEBS Lett, 1997, 410(1):17-21.
[16] Winkler R, Pasleau F, Boussif N, et al. The IGF system: summary and recent data[J]. Rev Med Liege, 2000, 55(7):725-739.
[17] Ge C, Xiao G, Jiang D, et al. Identification and functional characterization of ERK/MAPK phosphorylation sites in the Runx2 transcription factor[J]. J Biol Chem, 2009, 284(47):32533-32543.
[18] Li Q, Pan S, Dangaria SJ, et al. Platelet-rich fibrin promotes periodontal regeneration and enhances alveolar bone augmentation[J]. Biomed Res Int, 2013:638043.
[19] Zhao YH, Zhang M, Liu NX, et al. The combined use of cell sheet fragments of periodontal ligament stem cells and platelet-rich fibrin granules for avulsed tooth reimplantation[J]. Biomaterials, 2013, 34(22):5506-5520.
[20] He L, Lin Y, Hu X, et al. A comparative study of platelet-rich fibrin(PRF) and platelet-rich plasma (PRP) on the effect of proliferation and differentiation of rat osteoblasts in vitro[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2009, 108(5):707-713.
[21] Vo TN, Kasper FK, Mikos AG. Strategies for controlled delivery of growth factors and cells for bone regeneration[J]. Adv Drug Deliv Rev, 2012, 64(12):1292-1309.
[22] Kang YH, Jeon SH, Park JY, et al. Platelet-rich fibrin is a bioscaffold and reservoir of growth factors for tissue regeneration[J]. Tissue Eng Part A, 2011, 17(3/4):349-359.
[23] Chen FM, Zhang M, Wu ZF. Toward delivery of multiple growth factors in tissue engineering[J]. Biomaterials, 2010, 31(24):6279-6308.
[24] 罗晓丁. PRF用于口腔种植GBR手术组织愈合效果初步研究[D]. 天津: 天津医科大学, 2012. Luo XD. A preliminary study on the effect of platelet-rich fibrin on postoperative tissue healing after guided bone regeneration in dental implantation[D]. Tianjin: Tianjin Medical University, 2012.
[25] Suttapreyasri S, Leepong N. Influence of plateletrich fibrin on alveolar ridge preservation[J]. J Craniofac Surg, 2013, 24(4):1088-1094.
[26] 徐普, 朱亚丽, 程亚楠, 等. 即刻种植即刻负重中PRF 对软组织愈合的促进作用[J]. 中国口腔种植学杂志, 2012, 17(4):154-157.
Xu P Zhu YL, Cheng YN, et al. Promotion effect of PRF to soft tissue healing in immediate-implantimmediate-loading[J]. Chin J Oral Implantol, 2012, 17(4):154-157.
（本文采编 王晴）
[1] 廖洪林,方仲瀚,张艳艳,刘飞,沈颉飞. 牙种植术后三叉神经创伤性神经病理性疼痛的诊断与防治[J]. 国际口腔医学杂志, 2023, 50(6): 729-738.
[2] 刘云通,刘畅,高丽钞,罗瑜雪,曹钰彬,华成舸. 术后下牙槽神经功能障碍的研究进展[J]. 国际口腔医学杂志, 2023, 50(4): 479-484.
[3] 陆倩,夏海斌,王敏. 种植体磨光整形术治疗种植体周围炎的研究进展[J]. 国际口腔医学杂志, 2023, 50(2): 152-158.
[4] 蒋青松,赖文莉,王艳. 骨增量技术在口腔正畸领域的研究进展[J]. 国际口腔医学杂志, 2023, 50(2): 243-250.
[5] 胡文杰. 牙槽嵴保存术的临床实施问题探讨[J]. 国际口腔医学杂志, 2021, 48(3): 249-259.
[6] 吴洁林,高莺. 硬腭获取游离软组织移植物的应用进展[J]. 国际口腔医学杂志, 2020, 47(6): 686-692.
[7] 于婉琦,周延民,赵静辉. 口腔种植体新材料的研究现状[J]. 国际口腔医学杂志, 2019, 46(4): 488-496.
[8] 王美洁,谭欣,赵雨薇,于海洋. 即刻种植和传统种植对术后疼痛影响的对比研究[J]. 国际口腔医学杂志, 2019, 46(3): 292-296.
[9] 曹焜,李家锋,孙玉华,鲍强,卢秋宁,唐巍. 下颌下窝的锥形束CT影像分析[J]. 国际口腔医学杂志, 2019, 46(2): 209-212.
[10] 向琳,陈晖璐,袁影,张勤,辛娜,宫苹. 降钙素基因相关肽对种植体周围神经、血管再生及骨结合的作用[J]. 国际口腔医学杂志, 2018, 45(5): 509-515.
[11] 米梦梦,夏海斌,王敏. 釉基质蛋白衍生物在口腔种植中的研究进展[J]. 国际口腔医学杂志, 2018, 45(5): 522-526.
[12] 易芳,王斯任,褚衍昊,卢燕勤. 骨组织工程支架材料修复牙槽嵴裂的研究进展[J]. 国际口腔医学杂志, 2018, 45(5): 603-610.
[13] 朱宸佑, 魏诗敏, 汪媛婧, 伍颖颖. 巨噬细胞在骨组织修复中的研究进展[J]. 国际口腔医学杂志, 2018, 45(4): 444-448.
[14] 徐迅, 黄建生, 甘泽坤, 罗震. 上颌第一磨牙区腭侧骨板的锥形束CT测量结果及其临床意义[J]. 国际口腔医学杂志, 2017, 44(6): 686-690.
[15] 苟敏 蔡潇潇. 种植体—基台微间隙对种植体颈部周围骨的影响[J]. 国际口腔医学杂志, 2015, 42(6): 733-738.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] 张新春. 桩冠修复与无髓牙的保护[J]. 国际口腔医学杂志, 1999, 26(06): .
[2] 王昆润. 长期单侧鼻呼吸对头颅发育有不利影响[J]. 国际口腔医学杂志, 1999, 26(05): .
[3] 彭国光. 颈淋巴清扫术中颈交感神经干的解剖变异[J]. 国际口腔医学杂志, 1999, 26(05): .
[4] 杨凯. 淋巴化疗的药物运载系统及其应用现状[J]. 国际口腔医学杂志, 1999, 26(05): .
[5] 康非吾. 种植义齿下部结构生物力学研究进展[J]. 国际口腔医学杂志, 1999, 26(05): .
[6] 柴枫. 可摘局部义齿用Co-Cr合金的激光焊接[J]. 国际口腔医学杂志, 1999, 26(04): .
[7] 孟姝,吴亚菲,杨禾. 伴放线放线杆菌产生的细胞致死膨胀毒素及其与牙周病的关系[J]. 国际口腔医学杂志, 2005, 32(06): 458 -460 .
[8] 费晓露,丁一,徐屹. 牙周可疑致病菌对口腔黏膜上皮的粘附和侵入[J]. 国际口腔医学杂志, 2005, 32(06): 452 -454 .
[9] 赵兴福,黄晓晶. 变形链球菌蛋白组学研究进展[J]. 国际口腔医学杂志, 2008, 35(S1): .
[10] 庞莉苹,姚江武. 抛光和上釉对陶瓷表面粗糙度、挠曲强度及磨损性能的影响[J]. 国际口腔医学杂志, 2008, 35(S1): .