国际口腔医学杂志

国际口腔医学杂志 ›› 2021, Vol. 48 ›› Issue (2): 218-224.doi: 10.7518/gjkq.2021033

• 综述 • 上一篇    下一篇

帕金森病与口腔疾病相关性的研究进展

陈静(),葛子瑜,俞婷婷,章燕珍()   

  1. 浙江大学医学院附属第二医院综合牙科 杭州 310009
  • 收稿日期:2020-06-16 修回日期:2020-10-22 出版日期:2021-03-01 发布日期:2021-03-17
  • 通讯作者: 章燕珍
  • 作者简介:陈静,住院医师,学士,Email: 21818721@zju.edu.cn

Research progress on the correlation between Parkinson's disease and oral diseases

Chen Jing(),Ge Ziyu,Yu Tingting,Zhang Yanzhen()   

  1. Dept. of General Dentistry, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China
  • Received:2020-06-16 Revised:2020-10-22 Online:2021-03-01 Published:2021-03-17
  • Contact: Yanzhen Zhang

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摘要：

帕金森病（PD）是一种复杂的神经退行性疾病,好发于老年人。近年来,学者们对PD的研究越来越深入,但对相关口腔疾病的认识却略有不足。在PD人群中,许多口腔疾病较普通人群更高发,如龋病、牙周病、牙列缺损或缺失、流涎、口干症、磨牙症、颞下颌关节紊乱病和味觉减退等。本文就近年来围绕PD和口腔疾病的相关性研究作一综述,讨论了相关口腔疾病的流行病学现状、发病机制、预防和治疗方法,并认为口腔医师应当成为PD患者治疗团队中不可或缺的一员,以改善患者的口腔健康和生活质量。

关键词: 口腔疾病, 帕金森病, 治疗

Abstract:

Parkinson,s disease (PD) is a complex neurodegenerative disease that is pre-disposed to the elderly. PD has been extensively studied in recent years. However, the study on oral diseases in relation with PD is still insufficient. Patients with PD are prone to develop various oral diseases, such as dental caries, periodontal diseases, dentition defect, hyper-salivation, xerostomia, bruxism, temporomandibular disorders and impairment of taste. According to the available information and latest study on PD, this review was conducted to discuss the correlation between PD and oral diseases by analysing their epidemiology, pathophysiology, prevention and treatment. We believe that the dentist should be an indispensable member of the treatment team for patients with PD to improve their oral health and quality of life.

Key words: oral diseases, Parkinson's disease, treatment

中图分类号: 

  • R782
[1] Ascherio A, Schwarzschild MA. The epidemiology of Parkinson,s disease: risk factors and prevention[J]. Lancet Neurol, 2016,15(12):1257-1272.
doi: 10.1016/S1474-4422(16)30230-7 pmid: 27751556
[2] Tysnes OB, Storstein A. Epidemiology of Parkin-son,s disease[J]. J Neural Transm(Vienna), 2017,124(8):901-905.
[3] Tomita S, Oeda T, Umemura A, et al. Video-fluoroscopic swallowing study scale for predicting aspiration pneumonia in Parkinson,s disease[J]. PLoS One, 2018,13(6):e0197608.
doi: 10.1371/journal.pone.0197608 pmid: 29874285
[4] Ohtsu A, Takeuchi Y, Katagiri S, et al. Influence of Porphyromonas gingivalis in gut microbiota of streptozotocin-induced diabetic mice[J]. Oral Dis, 2019,25(3):868-880.
doi: 10.1111/odi.13044 pmid: 30667148
[5] Zhao XY, Liu ZJ, Shu DL, et al. Association of perio-dontitis with rheumatoid arthritis and the effect of non-surgical periodontal treatment on disease activity in patients with rheumatoid arthritis[J]. Med Sci Monit, 2018,24:5802-5810.
doi: 10.12659/MSM.909117 pmid: 30124222
[6] Lane H, Rose LE, Woodbrey M, et al. Exploring the effects of using an oral appliance to reduce movement dysfunction in an individual with parkinson disease: a single-subject design study[J]. J Neurol Phys Ther, 2017,41(1):52-58.
doi: 10.1097/NPT.0000000000000160 pmid: 27977521
[7] van Stiphout MAE, Marinus J, van Hilten JJ, et al. Oral health of Parkinson,s disease patients: a case-control study[J]. Parkinsons Dis, 2018,2018:1-8.
[8] Hanaoka A, Kashihara K. Increased frequencies of caries, periodontal disease and tooth loss in patients with Parkinson,s disease[J]. J Clin Neurosci, 2009,16(10):1279-1282.
doi: 10.1016/j.jocn.2008.12.027
[9] Müller T, Palluch R, Jackowski J. Caries and perio-dontal disease in patients with Parkinson,s disease[J]. Spec Care Dentist, 2011,31(5):178-181.
doi: 10.1111/j.1754-4505.2011.00205.x pmid: 21950532
[10] Kennedy MA, Rosen S, Paulson GW, et al. Relationship of oral microflora with oral health status in Parkinson,s disease[J]. Spec Care Dentist, 1994,14(4):164-168.
doi: 10.1111/j.1754-4505.1994.tb01125.x pmid: 7716701
[11] Cicciù M, Risitano G, Lo Giudice G, et al. Periodontal health and caries prevalence evaluation in patients affected by Parkinson,s disease[J]. Parkinsons Dis, 2012,2012:541908.
doi: 10.1155/2012/541908 pmid: 23320249
[12] Pradeep AR, Singh SP, Martande SS, et al. Clinical evaluation of the periodontal health condition and oral health awareness in Parkinson,s disease patients[J]. Gerodontology, 2015,32(2):100-106.
doi: 10.1111/ger.12055 pmid: 23718321
[13] Laugisch O, Johnen A, Maldonado A, et al. Perio-dontal pathogens and associated intrathecal antibodies in early stages of Alzheimer,s disease[J]. J Alzheimers Dis, 2018,66(1):105-114.
doi: 10.3233/JAD-180620 pmid: 30223397
[14] Kaur T, Uppoor A, Naik D. Parkinson,s disease and periodontitis-the missing link? A review[J]. Gero-dontology, 2016,33(4):434-438.
[15] Chen HL, Zhang SM, Hernán MA, et al. Nonsteroidal anti-inflammatory drugs and the risk of Parkinson disease[J]. Arch Neurol, 2003,60(8):1059-1064.
[16] Wang RP, Ho YS, Leung WK, et al. Systemic inflammation linking chronic periodontitis to cognitive decline[J]. Brain Behav Immun, 2019,81:63-73.
pmid: 31279681
[17] Ebersole JL, Cappelli D. Acute-phase reactants in infections and inflammatory diseases[J]. Periodontol 2000, 2000,23(1):19-49.
[18] Zhang Y, Leveille SG, Edward J. Wisdom teeth, periodontal disease, and C-reactive protein in US adults[J]. Public Health, 2020,187:97-102.
pmid: 32942171
[19] Ugalde-Muñiz P, Fetter-Pruneda I, Navarro L, et al. Chronic systemic inflammation exacerbates neurotoxicity in a Parkinson,s disease model[J]. Oxid Med Cell Longev, 2020,2020:4807179.
pmid: 32015787
[20] Friedlander AH, Mahler M, Norman KM, et al. Parkinson disease: systemic and orofacial manifestations, medical and dental management[J]. J Am Dent Assoc, 2009,140(6):658-669.
pmid: 19491161
[21] Packer M, Nikitin V, Coward T, et al. The potential benefits of dental implants on the oral health quality of life of people with Parkinson,s disease[J]. Gero-dontology, 2009,26(1):11-18.
[22] Nienstedt JC, Buhmann C, Bihler M, et al. Drooling is no early sign of dysphagia in Parkinson,s disease[J]. Neurogastroenterol Motil, 2018,30(4):e13259.
doi: 10.1111/nmo.13259 pmid: 29178420
[23] Fereshtehnejad SM, Skogar Ö, Lökk J. Evolution of orofacial symptoms and disease progression in idiopathic Parkinson,s disease: longitudinal data from the JöNköPing Parkinson registry[J]. Parkinsons Dis, 2017,2017:7802819.
[24] Jellinger KA. Neuropathology of nonmotor symptoms of Parkinson,s disease[J]. Int Rev Neurobiol, 2017,133:13-62.
pmid: 28802920
[25] Kalf JG, Bloem BR, Munneke M. Diurnal and nocturnal drooling in Parkinson,s disease[J]. J Neurol, 2012,259(1):119-123.
doi: 10.1007/s00415-011-6138-2 pmid: 21698387
[26] Rana AQ, Yousuf MS, Awan N, et al. Impact of progression of Parkinson,s disease on drooling in va-rious ethnic groups[J]. Eur Neurol, 2012,67(5):312-314.
[27] Karakoc M, Yon MI, Cakmakli GY, et al. Pathophy-siology underlying drooling in Parkinson,s disease: oropharyngeal bradykinesia[J]. Neurol Sci, 2016,37(12):1987-1991.
doi: 10.1007/s10072-016-2708-5 pmid: 27613712
[28] Fukuoka T, Ono T, Hori K, et al. Tongue pressure measurement and videofluoroscopic study of swallowing in patients with Parkinson,s disease[J]. Dysphagia, 2019,34(1):80-88.
doi: 10.1007/s00455-018-9916-5 pmid: 29948261
[29] Jolly DE, Paulson RB, Paulson GW, et al. Parkin-son,s disease: a review and recommendations for dental management[J]. Spec Care Dentist, 1989,9(3):74-78.
doi: 10.1111/j.1754-4505.1989.tb01032.x pmid: 2533711
[30] Ondo WG, Hunter C, Moore W. A double-blind placebo-controlled trial of botulinum toxin B for sialorrhea in Parkinson,s disease[J]. Neurology, 2004,62(1):37-40.
[31] Salat-Foix D, Suchowersky O. The management of gastrointestinal symptoms in Parkinson,s disease[J]. Expert Rev Neurother, 2012,12(2):239-248.
doi: 10.1586/ern.11.192 pmid: 22288679
[32] Cersosimo MG, Raina GB, Calandra CR, et al. Dry mouth: an overlooked autonomic symptom of Parkinson,s disease[J]. J Parkinsons Dis, 2011,1(2):169-173.
pmid: 23939300
[33] Cersósimo MG, Tumilasci OR, Raina GB, et al. Hyposialorrhea as an early manifestation of Parkinson disease[J]. Auton Neurosci, 2009,150(1/2):150-151.
[34] Del Tredici K, Hawkes CH, Ghebremedhin E, et al. Lewy pathology in the submandibular gland of individuals with incidental Lewy body disease and sporadic Parkinson,s disease[J]. Acta Neuropathol, 2010,119(6):703-713.
pmid: 20229352
[35] Buzalaf MAR, Ortiz AC, Carvalho TS, et al. Saliva as a diagnostic tool for dental caries, periodontal disease and cancer: is there a need for more biomarkers[J]. Expert Rev Mol Diagn, 2020,20(5):543-555.
doi: 10.1080/14737159.2020.1743686 pmid: 32223655
[36] Flink H, Tegelberg Å, Arnetz JE, et al. Self-reported oral and general health related to xerostomia, hyposalivation, and quality of life among caries active younger adults[J]. Acta Odontol Scand, 2020,78(3):229-235.
doi: 10.1080/00016357.2019.1690677 pmid: 31729277
[37] Barbe AG, Deutscher DHC, Derman SHM, et al. Subjective and objective halitosis among patients with Parkinson,s disease[J]. Gerodontology, 2017,34(4):460-468.
doi: 10.1111/ger.12293 pmid: 28857268
[38] Koshimune S, Awano S, Gohara K, et al. Low salivary flow and volatile sulfur compounds in mouth air[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2003,96(1):38-41.
pmid: 12847442
[39] Kleinberg I, Wolff MS, Codipilly DM. Role of saliva in oral dryness, oral feel and oral malodour[J]. Int Dent J, 2002,52(Suppl 3):236-240.
doi: 10.1002/j.1875-595X.2002.tb00932.x
[40] DeBowes SL, Tolle SL, Bruhn AM. Parkinson,s di-sease: considerations for dental hygienists[J]. Int J Dent Hyg, 2013,11(1):15-21.
doi: 10.1111/j.1601-5037.2012.00548.x
[41] Agbo-Godeau S, Guedj A, Marès S, et al. Xerostomia[J]. Presse Med, 2017,46(3):296-302.
doi: 10.1016/j.lpm.2017.02.004 pmid: 28366533
[42] Verhoeff MC, Lobbezoo F, Wetselaar P, et al. Parkinson,s disease, temporomandibular disorders and bruxism: a pilot study[J]. J Oral Rehabil, 2018,45(11):854-863.
doi: 10.1111/joor.12697 pmid: 30024048
[43] Lobbezoo F, Naeije M. Bruxism is mainly regulated centrally, not peripherally[J]. J Oral Rehabil, 2001,28(12):1085-1091.
doi: 10.1046/j.1365-2842.2001.00839.x pmid: 11874505
[44] Ribeiro GR, Campos CH, Rodrigues Garcia RCM. Parkinson,s disease impairs masticatory function[J]. Clin Oral Investig, 2017,21(4):1149-1156.
doi: 10.1007/s00784-016-1879-z pmid: 27291219
[45] Rodrigues Ribeiro G, Heitor Campos C, Barbosa Câmara-Souza M, et al. Masticatory function and oral sensorimotor ability in Parkinson,s disease: levodopa on versus off periods[J]. Spec Care Dentist, 2019,39(2):77-83.
doi: 10.1111/scd.12351 pmid: 30597591
[46] Chen YY, Fan HC, Tung MC, et al. The association between Parkinson,s disease and temporomandibular disorder[J]. PLoS One, 2019,14(6):e0217763.
doi: 10.1371/journal.pone.0217763 pmid: 31199837
[47] Nomoto S, Nakamura M, Sato T, et al. Occlusal treatment with bite splint improves dyskinesia in Parkinson,s disease patient: a case report[J]. Bull Tokyo Dent Coll, 2013,54(3):157-161.
doi: 10.2209/tdcpublication.54.157 pmid: 24334629
[48] Pinganaud G, Bourcier F, Buisseret-Delmas C, et al. Primary trigeminal afferents to the vestibular nuclei in the rat: existence of a collateral projection to the vestibulo-cerebellum[J]. Neurosci Lett, 1999,264(1/2/3):133-136.
[49] Milani RS, De Perière DD, Lapeyre L, et al. Relationship between dental occlusion and posture[J]. Cranio, 2000,18(2):127-134.
doi: 10.1080/08869634.2000.11746124 pmid: 11202823
[50] Krause F, Wilke J, Vogt L, et al. Intermuscular force transmission along myofascial chains: a systematic review[J]. J Anat, 2016,228(6):910-918.
doi: 10.1111/joa.12464 pmid: 27001027
[51] Ricatti MJ, Ottaviani S, Boschi F, et al. A prospective evaluation of taste in Parkinson,s disease[J]. J Neural Transm (Vienna), 2017,124(3):347-352.
[52] Kashihara K, Hanaoka A, Imamura T. Frequency and characteristics of taste impairment in patients with Parkinson,s disease: results of a clinical interview[J]. Intern Med, 2011,50(20):2311-2315.
doi: 10.2169/internalmedicine.50.5935 pmid: 22001456
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[5] 逄键梁. 两例外胚层发育不良儿童骨内植入种植体后牙槽骨生长情况[J]. 国际口腔医学杂志, 1999, 26(05): .
[6] 温秀杰. 氟化物对牙本质脱矿抑制作用的体外实验研究[J]. 国际口腔医学杂志, 1999, 26(05): .
[7] 杨春惠. 耳颞神经在颞颌关节周围的分布[J]. 国际口腔医学杂志, 1999, 26(04): .
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