国际口腔医学杂志 ›› 2018, Vol. 45 ›› Issue (3): 340-345.doi: 10.7518/gjkq.2018.03.018

• 综述 • 上一篇    下一篇

硅酸镁锂在骨组织工程中的研究进展

梁馨予, 石佳博, 陈文川, 朱智敏   

  1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院修复1科 成都 610041
  • 收稿日期:2017-07-12 修回日期:2017-12-22 发布日期:2018-05-08
  • 通讯作者: 朱智敏,教授,博士,Email:zzhimin@163.com
  • 作者简介:梁馨予,博士,Email:1362171184@qq.com

Research progress on synthetic nanosilicates in bone tissue engineering

Liang Xinyu, Shi Jiabo, Chen Wenchuan, Zhu Zhimin   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Prosthodontics 1, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2017-07-12 Revised:2017-12-22 Published:2018-05-08

摘要: 硅酸镁锂是一种纳米黏土材料,因其具有的细胞水平大小、带电片晶结构和较高的表体积比,易与蛋白分子、细胞、聚合物交联。随着对硅酸镁锂研究的不断深入,近年来该材料已逐渐发展到骨组织工程领域。本文以硅酸镁锂的物理化学性质和生物学性质为基础,对骨组织工程中硅酸镁锂对种子细胞功能调控、生长因子递载以及基质材料改良的研究进展作一综述,以期为该材料在骨组织工程中的应用研究提供参考。

关键词: 硅酸镁锂, 骨组织工程, 成骨诱导, 载体, 基质材料, 硅酸镁锂, 骨组织工程, 成骨诱导, 载体, 基质材料

Abstract: Synthetic nanosilicates are clay nanoparticles that have a cellular-level size, distinct charged and layered structure, and high surface-to-volume ratio, which enhances their interactions with proteins, cells, and polymers. Recently, researchers have focused on the implications of using synthetic nanosilicates in bone tissue engineering to understand their physicochemical and biological properties. The scope of this review includes the well-established use of synthetic nanosilicates for the adjustment of cell functions during bone tissue engineering. The interactions of synthetic nanosilicates with growth factors enable controlled delivery, and their mechanical or biological properties are enhanced when they interact matrix materials. This review is useful to future studies on synthetic nanosilicates.

Key words: synthetic nanosilicates, bone tissue engineering, osteoinduction, carrier, matrix material, synthetic nanosilicates, bone tissue engineering, osteoinduction, carrier, matrix material

中图分类号: 

  • R783.1
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