国际口腔医学杂志 ›› 2016, Vol. 43 ›› Issue (2): 223-227.doi: 10.7518/gjkq.2016.02.024

• 综述 • 上一篇    下一篇

口腔细菌黏附机制的研究进展

郑赛男,蒋丽,李伟   

  1. 口腔疾病研究国家重点实验室 华西口腔医院(四川大学) 成都 610041
  • 收稿日期:2015-06-01 修回日期:2015-12-16 出版日期:2016-03-01 发布日期:2016-03-01
  • 通讯作者: 李伟,教授,博士,Email:leewei@scu.edu.cn
  • 作者简介:郑赛男,硕士,Email:584365144@qq.com
  • 基金资助:
    国家自然科学基金(31200720);教育部博士点新教师基金(20120181120009)

Research progress on oral bacterial adhesion mechanism

Zheng Sainan, Jiang Li, Li Wei   

  1. State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China)
  • Received:2015-06-01 Revised:2015-12-16 Online:2016-03-01 Published:2016-03-01

摘要: 口腔细菌黏附的机制是口腔微生物学和生态学的研究热点之一,近年来,随着分子生物研究水平的提高,口腔细菌黏附机制的研究在分子水平上有了较大的进展。细菌表面的黏附蛋白和受体以及菌毛和胞外多糖都参与细菌间的共聚及细菌对牙表面的黏附。材料表面的获得性薄膜、粗糙度、表面电荷和疏水性等特性也能影响细菌的定植和黏附。本文就细菌和材料两个方面对口腔细菌黏附的机制及控制细菌黏附的方法作一综述。

关键词: 细菌黏附, 黏附蛋白, 受体, 菌毛, 唾液薄膜, 细菌黏附, 黏附蛋白, 受体, 菌毛, 唾液薄膜

Abstract: Oral bacterial adhesion mechanism is one of the focus studies in the research on oral microbiology and ecology. In recent years, with the improvement of molecular biology, the study of mechanism of oral bacteria adhesion has exhibited considerable progress at the molecular level. The adhesion protein-receptors, fimbriae, and exopolysaccharides on bacterial surface are responsible for the coaggregation of bacteria and adhesion of bacteria to teeth. The acquired pellicle on the material surface and several characteristics of the material, such as roughness, surface charge, and hydrophobicity, can affect bacterial colonization and adhesion. In this paper, the mechanism of oral bacteria adhesion from both bacteria and material, as well as the methods to control bacterial adhesion, are reviewed.

Key words: bacteria adhesion, adhesion protein, receptor, fimbria, salivary pellicle, bacteria adhesion, adhesion protein, receptor, fimbria, salivary pellicle

中图分类号: 

  • R 780.2
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