关键词: 红细胞生成素, 红细胞生成素受体, 成骨细胞, 信号传导通路, 贾纳斯激酶, 信号转导子和转录激活子, 磷脂酰肌醇-3-激酶, 蛋白激酶B

Abstract:

Erythropoietin(EPO) and its receptor(EPOR) binding triggers signal transduction, regulating the proliferation and differentiation of red blood cells. EPO activates the Janus kinase (JAK) and its downstream mitogen activated protein kinase(MAPK), phosphatidylinositol-3- kinase(PI3K), signal transducer and activator of transcription(STAT) signal pathway, involved in the regulation of primitive stem cell development, cell integrity, vascular regeneration and neural development. EPO can promote bone marrow mesenchymal stem cells into osteoblasts differentiation, promoting osteoblastic bone formation and fracture healing, in distraction osteogenesis can accelerate bone healing. EPO and EPOR in bone marrow mesenchymal stem cells or bone marrow stromal cells and osteoblastic differentiation and osteogenic cells, mainly through the JAK-STAT, PI3K-protein kinase B(PKB), MAPK and NF-κB signal transduction pathway plays a role, and then promote the osteogenesis of bone cells, which for the orthodontic tooth movement and oral maxillofacial distraction osteogenesis has very important clinical significance.

Key words: erythropoietin, erythropoietin receptor, osteoblast, signal transduction pathway, Janus kinase, signal transduction and activator of transcription, phosphatidylinositol-3-kinase, protein kinase B