Table of Content

    01 January 2016, Volume 43 Issue 1 Previous Issue    Next Issue
    Common cause and sequential treatment of food impaction
    Luo Yun, Ren Jie
    Inter J Stomatol. 2016, 43 (1):  1.  DOI: 10.7518/gjkq.2016.01.001
    Abstract ( 1532 )   HTML ( 19 )   PDF(pc) (5221KB) ( 1834 )   Save

    Food impaction is a commonly clinical symptom that can be caused by a series of oral diseases. It can do harm to the patients’ daily life. This passage focuses on the common cause and the treatment of food impaction. We wish more dentists can keep an eye on the symptom and do better to serve the patients.

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    Impact of root canal flushing fluid on the accuracy of electronic apex locator
    Xue Ming, Ge Jiuyu, Cheng Lei
    Inter J Stomatol. 2016, 43 (1):  5.  DOI: 10.7518/gjkq.2016.01.002
    Abstract ( 1507 )   HTML ( 12 )   PDF(pc) (1147KB) ( 1814 )   Save

    With the constant improvement of the level of root canal therapy, in order to more thoroughly remove root canal spondylolysis, dentin tubule and collateral material, root canal infection often use chemical preparation joint mechanical preparation to the entire root canal disinfection sterilization system.By far the most common root canal irrigation drugs with sodium hypochlorite solution and 17% edta, etc.So, different concentrations of sodium hypochlorite on electronic root interferences with the accuracy of the instrument?Invited several experts under the column of the current schools of thought contend, just root canal rinses the electronic measuring instrument accuracy of influence are discussed.With the constant improvement of the level of root canal therapy, in order to more thoroughly remove root canal spondylolysis, dentin tubule and collateral material, root canal infection often use chemical preparation joint mechanical preparation to the entire root canal disinfection sterilization system.By far the most common root canal irrigation drugs with sodium hypochlorite solution and 17% edta, etc.So, different concentrations of sodium hypochlorite on electronic root interferences with the accuracy of the instrument?Invited several experts under the column of the current schools of thought contend, just root canal rinses the electronic measuring instrument accuracy of influence are discussed.

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    Evaluate different placement technique of mineral trioxide aggregate using portland cement: an in vitro study
    Wang Ruyan1,2, Song Ying3, Huang Dingming1, Gao Yuan1.
    Inter J Stomatol. 2016, 43 (1):  8.  DOI: 10.7518/gjkq.2016.01.003
    Abstract ( 1267 )   HTML ( 6 )   PDF(pc) (16386KB) ( 914 )   Save

    Objective To evaluate the effect of four different placement techniques on the edge sealing and compactness of mineral trioxide aggregate(MTA) using Portland cement(PC), and the impact of using conveyor on residual materials on the root canal wall. Methods Established large apical straight root canal model and trumpet-shaped straight root canal model. Using four different placement techniques(Gutta-percha, EndoActivator, direct ultrasonic and indirect ultrasonic) placement PC in two models. Then they were observed and scored under a stereomicroscope. Using delivery and plugger transport PC into large apical root canal model, then the PC that residual on the root canal wall was measured. Results In guttapercha group, large apical root canal was great than trumpet-shaped straight root canal(P<0.05). In large apical root canal, indirect ultrasonic and gutta-percha were great than the other two(P<0.05). And the residual MTA on the root canal wall using delivery was less than plugger(P<0.05). In trumpet-shaped straight root canal, indirect ultrasonic was great than the other three(P<0.01). Conclusion It can decrease MTA that residual on the root canal wall by using delivery. When place MTA in large apical root canal, gutta-percha and indirect ultrasonic are both good choice, while indirect ultrasonic is the best choice in trumpet-shaped straight root canal.

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    Comparative study of two cone beam computed tomography systems in the detection of vertical root fractures
    Zhai Fei1, Qi Senrong2, Hou Benxiang1
    Inter J Stomatol. 2016, 43 (1):  13.  DOI: 10.7518/gjkq.2016.01.004
    Abstract ( 1366 )   HTML ( 6 )   PDF(pc) (3658KB) ( 1490 )   Save

    Objective To compare the sensitivity of two clinically used cone beam computed tomography(CBCT) systems in detecting vertical root fracture(VRF) with or without canal filling of gutta-percha and evaluate the impacts of reconstruction plane(axial, sagittal or coronal) and root plane(cervical, middle or apical) on the sensitivity of diagnosis. Methods The 20 single constant mandibular premolar were researched, root in the specimens of mandibular first before grinding fang, alveolus socket according to different processing steps in turn has taken CBCT with small and large fov respectively four times, record the following 4 kinds of circumstances: no VRF+no root filling, no VRF+gutta-percha filling, VRF+no root filling, VRF+gutta-percha filling. The images were evaluated by two independent observers. Results 1)In the absence and presence of gutta-percha, CBCT with small fov was the most sensitive and accurate method in diagnosing VRF, compared with CBCT with large fov(P<0.05); 2)In the presence of gutta-percha, diagnoses based on observation of the axial slices at the apical third of the roots obtained by using either of the CBCT techniques were the most sensitive method in detecting VRF. Conclusion CBCT with small fov was the most sensitive imaging technique in detecting vertical root fracture compared with CBCT with large fov. In the presence of canal filling of gutta-percha, the image artifact weakened from the coronal portion to the apical portion. Diagnoses based on observation of the axial slices at the apical third of the roots were the most sensitive in detecting VRF.

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    The effects of Liuwei Dihuang Pill to interleukin-6 and estrogen in gingival crevicular fluid before and after treatment of periodontal during the postmenopausal women
    Ren Qiang1, Li Chunnian2, Yang Dongru2
    Inter J Stomatol. 2016, 43 (1):  18.  DOI: 10.7518/gjkq.2016.01.005
    Abstract ( 1235 )   HTML ( 5 )   PDF(pc) (1268KB) ( 954 )   Save

    Objective To investigate the influence of Liuwei Dihuang Pill(LWDHP) treating periodontal during the postmenopausal women. Methods Twenty-seven postmenopausal female patients with moderate to advanced chronic periodontal disease were chosen, and were divided into two groups randomly. Basic treatment group: patients didn’t take any medicine, only accept initial therapy of periodontal. LWDHP treatment group: initial therapy of periodontal with oral took LWDHP 2 months. Collected and detected the concentration of interleukin(IL)-6, estrogen(E2) in gingival crevicular fluid(GCF) before and after treatment. Results A significant decrease was shown in the concentrations of GCF-IL-6 of two groups after therapy compared to before treatment on 2nd month, it had statistically differences(P<0.01), there were no statistically significant differences between the two groups(P>0.05). Basic treatment group increased the concentrations of GCF-E2 of two groups after therapy compared to before treatment on 2nd month. Basic treatment group had no statistically significant difference(P>0.05), LWDHP treatment group had statistically significant differences(P<0.01). Conclusion Periodontal initial therapy can make the concentration of IL-6 in GCF decrease and improves periodontal condition. The concentration of E2 in GCF could be increased by LWDHP.

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    Effect of psychological intervention on the treatment of oral lichen planus
    Zhou Yi, Sun Xiurong, Liu Xueli, Yan Shixia
    Inter J Stomatol. 2016, 43 (1):  22.  DOI: 10.7518/gjkq.2016.01.006
    Abstract ( 1079 )   HTML ( 7 )   PDF(pc) (1117KB) ( 1121 )   Save

    Objective To explore the effect of psychological intervention on the relief of oral lichen planus(OLP). Methods Two hundred and ten patients with OLP were randomly divided into two groups, 105 patients in the treatment of drug treatment, based on the psychological treatment, as a psychological treatment group; 105 cases of drug treatment, as the control group. Recorded 2 groups of patients psychological scale scores and mucosal damage to score points(including signs and symptoms score) and treatment efficacy respectively in the first option, 2 weeks after treatment, 1 month, 3 months, 6 months and 9 months after the visit. Results The OLP lesion signs and symptoms score of psychological treatment group decreased significantly, and lesions of the OLP healing time was shortened, relieve pain, prolonged remission. The difference between the two groups was statistically significant(P<0.01). Conclusion The healing OLP effect of psychological treatment is obvious, the method is simple.

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    Meta-analysis of pantomography for the diagnosis of mandibular invasion caused by oral cancers
    Li Tang, Li Chunjie, Men Yi, Yang Wenbin, Han Bo, Li Longjiang
    Inter J Stomatol. 2016, 43 (1):  26.  DOI: 10.7518/gjkq.2016.01.007
    Abstract ( 1310 )   HTML ( 10 )   PDF(pc) (1154KB) ( 909 )   Save

    Objective This study aimed to assess the diagnostic efficacy of pantomography in the screening of mandibular invasion by oral cancers. Methods Seven electronic databases, including MEDLINE, EMBASE, MEDION, and CBM, were searched electronically on October 25, 2014. Hand-searching was also performed. QUADAS-2 was used by two independent reviewers to assess the methodological quality, and data extraction of included studies was delivered by two reviewers in duplicate. Meta-analysis was conductedvia MetaDisc 1.4. Results A total of 12 studies involving 528 participants were included. Sevenstudies were prospective, 2 had high risk of bias, and the rest had unclear risk of bias. Meta-analysis showed that when screening mandibular invasion, pantomography had a pooled sensitivity of 0.761, pooled specificity of 0.828, area under curve of 0.884, and Q* of 0.814. Conclusion Pantomography is a good tool for oral cancer mandibular invasion screening. More studies on mandible medullary invasion diagnosed by pantomography should be conducted.

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    Clinical discussion of infections in the bone-grafted area after maxillary sinus floor elevation
    Li Tingwei1,2, Tang Jingxia2, Huang Fengqiong2, Liu Weijun1
    Inter J Stomatol. 2016, 43 (1):  31.  DOI: 10.7518/gjkq.2016.01.008
    Abstract ( 1639 )   HTML ( 9 )   PDF(pc) (2577KB) ( 1222 )   Save

    Maxillary sinus floor elevation is a common solution to the lack of dental bone implant. Infections are less commonly observed in bone-grafted areas. For instance, 1 out of 100 cases is infected. The main clinical symptoms are manifested in the affected side of migraine. Systemic and local antibiotic treatments are ineffective. In maxillary sinus floor elevation, a hole is bored in the region of the lateral wall of the maxillary sinus to create a drainage. This procedure yields optimum effect.

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    Two cases of supernumerary teeth located in the mandibular incisor region
    Peng Jiamei
    Inter J Stomatol. 2016, 43 (1):  34.  DOI: 10.7518/gjkq.2016.01.009
    Abstract ( 1235 )   HTML ( 12 )   PDF(pc) (5318KB) ( 1223 )   Save

    Supernumerary teeth are commonly affected by dentin dysplasia, a condition manifested when the number of teeth exceeds that of normal teeth. Supernumerary teeth are usually found in maxillary anterior areas and in maxillary molar areas. In other instances, supernumerary teeth are located in mandibular molar areas and mandibular premolar areas. In this report, two cases possessed five incisors located in the mandibular anterior region.

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    A case report of right mandibular fourth molar
    Li Feng, Xie Xiaoyan
    Inter J Stomatol. 2016, 43 (1):  36.  DOI: 10.7518/gjkq.2016.01.010
    Abstract ( 1193 )   HTML ( 9 )   PDF(pc) (11422KB) ( 726 )   Save

    The appearance of a fourth molar, particularly that located in the mandible, is a relatively rare dental dysplasia. A case of right mandibular fourth molar is reported in this paper.

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    Local drug injection to treat idiopathic trigeminal neuralgia
    Xiang Zhenting, Zheng Xiaohui
    Inter J Stomatol. 2016, 43 (1):  38.  DOI: 10.7518/gjkq.2016.01.011
    Abstract ( 1066 )   HTML ( 7 )   PDF(pc) (1223KB) ( 791 )   Save

    Idiopathic trigeminal neuralgia is a common form of facial pain that severely affects the patients’ quality of life. However, treatments for trigeminal neuralgia vary because of the lack of knowledge on its etiological factors and mechanisms. Local drug injection is a useful and minimally invasive technique to manage trigeminal neuralgia easily; this treatment involves a wide range of drugs. This article aims to review the research progress on local drug injection to treat primary trigeminal neuralgia.

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    Research progress on the surgery-first approach to treat skeletal malocclusion
    Guo Peizhu, Feng Yunxia, Ren Juan
    Inter J Stomatol. 2016, 43 (1):  43.  DOI: 10.7518/gjkq.2016.01.012
    Abstract ( 954 )   HTML ( 6 )   PDF(pc) (1124KB) ( 1431 )   Save

    Adult orthodontic demands have increased; however, orthodontic and surgical treatments should be applied to elicit optimum therapeutic effects on severe osseous deformity. Orthodontic-orthognathic treatments include three aspects: preoperative orthodontic procedures, orthodontic-orthognathic operation, and postoperative orthodontic procedures. In preoperative orthodontic procedures, the compensation of teeth is removed to improve the coordination of soft tissues and bone tissues. Orthognathic operation is then performed. In postoperative orthodontic procedures, occlusion is further adjusted. This method requires a long time, and patients suffer from psychological and functional effects. Surgery-first approach(SFA) has been proposed to resolve the inconvenience caused by preoperative orthodontic procedures. This article summarizes the basic concepts, clinical applications, advantages, and disadvantages of SFAs.

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    Correlation between clinical diagnosis and magnetic resonance imaging findings of temporomandibular joint disorder
    Lü Chunxiao, Chen Song
    Inter J Stomatol. 2016, 43 (1):  47.  DOI: 10.7518/gjkq.2016.01.013
    Abstract ( 1099 )   HTML ( 9 )   PDF(pc) (1197KB) ( 888 )   Save

    Temporomandibular joint disorder(TMJD) is a common oral disease, and magnetic resonance imaging(MRI) is the most used assistance method for TMJD treatment. This article reviews the correlation between clinical diagnosis and MRI findings of TMJD.

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    Research progress on the role of HIPPO pathway in the development of the oral system and diseases
    Hao Xulei, Liang Xinhua
    Inter J Stomatol. 2016, 43 (1):  52.  DOI: 10.7518/gjkq.2016.01.014
    Abstract ( 1023 )   HTML ( 8 )   PDF(pc) (1204KB) ( 1152 )   Save

    HIPPO signaling pathway is a highly conservative signaling pathway involved in the regulation of cell proliferation, apoptosis, and organ sizes. This pathway is involved in human growth and development and is closely related to the occurrence of various diseases. Herein, we review the recent progress of research on HIPPO pathway in the dental field and the influence of HIPPO pathway on the development of the oral system and diseases. This review can provide new ideas and strategies for further investigations and treatment of oral diseasesh.

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    The colonization of oral bacteria in healthy children
    Du Qin1,2, Zou Jing1, Li Yuqing1, Li Mingyun1, Zhou Xuedong1
    Inter J Stomatol. 2016, 43 (1):  57.  DOI: 10.7518/gjkq.2016.01.015
    Abstract ( 1294 )   HTML ( 9 )   PDF(pc) (1123KB) ( 1259 )   Save

    A superogranism consisting of eukaryotic cells and microbial communities that symbiose in the human body. Mouth, as the entrance of microorganisms into human body, harbors one of the most complex ecosystem and microbiome of the human. The normal colonization and balance of the oral microbial community are essential for maintaining oral and systematic health. The oral microbiome varies most during childhood, when contact with external microbes is highest. In the first few months of life, the major influences on the oral microbial succession are from person-to-person transmission, mode of feeding, and microbial cross-talk. In the edentulous stage, microbial adhersion occurs only to the oral mucosa. With the eruption of the first teeth, a new ecological event takes place in the oral environment, with the emergence of new adhesion surfaces. So this happens when permanent teeth erupt.

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    Role of long noncoding RNA in periodontal disease and oral cancer
    Qu Qian1, Fang Fuchun1, Wu Buling1,2
    Inter J Stomatol. 2016, 43 (1):  62.  DOI: 10.7518/gjkq.2016.01.016
    Abstract ( 1163 )   HTML ( 9 )   PDF(pc) (1193KB) ( 971 )   Save

    Long noncoding RNA(lncRNA) are a group of endogenous transcripts that are longer than 200 nucleotides, lack a specific complete open reading frame, and have no or limited protein-coding capacity. lncRNA are considered transcriptional “noise” because of their lack of biological functions. However, recent studies have revealed that lncRNA participate in genome organization and in life processes such as the growth and development, proliferation, differentiation, and apoptosis of cells. Furthermore, lncRNA have been closely associated with the development of numerous diseases and are becoming the new direction of genome research. Previous research found that lncRNA are related to periodontal disease, oral premalignant lesions, and oral cancer. Over 60% of differently expressed lncRNA in cancer tissue can be found in oral cancer tissue. Therefore, lncRNA can be a biomarker and provide guidance for the clinical cure and prognosis of periodontal disease, oral premalignant lesion, and oral cancer.

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    Side effects of treating dental fear with midazolam
    Ma Huiqiang, Li Yang, Liu Guohui
    Inter J Stomatol. 2016, 43 (1):  66.  DOI: 10.7518/gjkq.2016.01.017
    Abstract ( 1880 )   HTML ( 8 )   PDF(pc) (1108KB) ( 1006 )   Save

    Dental fear is an abnormal psychology, physiology, and behavior exhibited by some people during dental treatment. Clinical manifestations of dental fear include rapid heartbeat, abnormal blood pressure, sweating, use of umerous words during speech, muscle tension, pale complexion, and syncope. Midazolam exerts anti-anxiety, sedative, hypnotic, anticonvulsive, and muscle-relaxing effects. Patients under midazolam may exhibit brief anterograde amnesia and may forget what happens during the drug peak. Major side effects of midazolam include cardiac arrest, heart rate change, allergic reaction, thrombosis, laryngospasm, bronchospasm, respiratory depression, and respiratory arrest. Minor side effectsof this drug include burping, nausea, vomiting, headache, dizziness, bed-wetting, hallucinations, dizziness, diplopia, and transient oxygen desaturation. Thus, analyzingthe side effects of midazolam and establishing a database of these side effects are necessary to provide guidance during the clinical application of midazolam.

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    Nerve regeneration after peripheral nerve injury and the effects of peripheral nerve regeneration around dental implant
    Yin Chengcheng, Li Baosheng, Cai Qing, Meng Weiyan
    Inter J Stomatol. 2016, 43 (1):  69.  DOI: 10.7518/gjkq.2016.01.018
    Abstract ( 1274 )   HTML ( 13 )   PDF(pc) (1200KB) ( 980 )   Save

    In the distal stump of injured peripheral nerves, Wallace degeneration occurs and the neurolemmal cells dedifferentiate and proliferate. Phagocyte pieces are also present in injured nerve ends, and factors are secreted to increase the amount of phagocytes in the e injured area and remove disintegrating myelin debris. Thus, neurolemmal cells guide axis regeneration, cover axon, and form myelin. In the early wound healing process after implanting operation, peri-implant neurofilament protein staining positive fibers and regenerated nerve fibers are the basis of oral sensation responses for implant patients. The microscale structure of different titanium surfaces is beneficial for the attachment and proliferation of nerve cells and secretion of nutritional factors. Nerve growth factor is essential for the growth and survival of sympathetic and sensory neurons. Heparin-conjugated fibrin gel implants and hydroxylapatite nerve growth factor composite coating titanium implants can release active nerve growth factors sustainably, promote nerve cell proliferation and regeneration, and improve early osseoperception of the implant. The mechanisms of how the microstructure and chemical composition promote peripheral nerve regeneration, as well as the relevant molecular mechanism, require further research.

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    Application of stromal vascular fraction in engineered adipose tissue construction
    Huang Jiao, Yu Mei, Tian Weidong
    Inter J Stomatol. 2016, 43 (1):  74.  DOI: 10.7518/gjkq.2016.01.019
    Abstract ( 1195 )   HTML ( 4 )   PDF(pc) (1201KB) ( 1270 )   Save

    The stromal vascular fraction contains adipose-derived stem cells and provides cytokines; this vascular fraction has been applied wildly in adipose tissue engineering field as a superior material compared with adipose-derived stem cells alone. This review illustrates the components and merits of stromal vascular fraction; summarizes stromal vascular fraction isolation methods and operation details; discusses the choices of scaffold materials; introduces cytokines in the micro-environment surrounding the stromal vascular fraction, which should be considered in engineered adipose tissue construction; analyzes two specific methods(i.e., mixture of the stromal vascular fraction and fat granules and mixture of the stromal vascular fraction and platelet-rich plasma or fibrin) to regenerate adipose tissue; and concludes with the obstacles of stromal vascular fraction in engineered adipose tissue construction. This review aims to contribute to the construction of engineered adipose tissue that can be applied in the clinical setting with higher survival rates and fewer complications.

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    Research progress on the association between DNA methylation and oral squamous cell carcinoma
    Tu Minsong1, Li Yisong2, Dai Xiaoming2
    Inter J Stomatol. 2016, 43 (1):  79.  DOI: 10.7518/gjkq.2016.01.020
    Abstract ( 1115 )   HTML ( 5 )   PDF(pc) (1142KB) ( 1174 )   Save

    DNA methylation disorders may increase the risk of human cancer. Research on DNA hypermethylation of cancer-related genes in oral squamous cells is relatively extensive; such research is based on detection via methylationspecific polymerase chain reaction and centered on healthy mucosa-associated tissues, as well as tumor tissue adjacent to carcinoma, to determine early diagnosis and malignant transformation. Research on oral squamous cell carcinoma generally focuses on the level of genomic DNA methylation using high-throughput detection technology. The expression levels of DNA methylation were obtained from healthy mucosa and precancerous lesions on squamous cell carcinoma. The results of this work provide a solid foundation for subsequent studies on the methylation of candidate genes.

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    Effect of frizzle in the wingless-type mice mammary tumor virus integration site family-frizzle signaling pathway
    Xu Jinzhao1, Lan Jing2, Ji Ping2
    Inter J Stomatol. 2016, 43 (1):  85.  DOI: 10.7518/gjkq.2016.01.021
    Abstract ( 1066 )   HTML ( 5 )   PDF(pc) (1204KB) ( 870 )   Save

    Frizzle(FRZ) was first identified in Drosophila and named as such for twisting together with wingless-type mice mammary tumor virus integration site family(WNT). FRZ is a family of cell surface receptors of WNT consisting of three regions; this family is also a member of the G protein-coupled receptor(GPCR) family for having or missing some basic GPCR structures. FRZ signaling pathways can be divided into canonical and non-canonical signaling pathways; the former relies on transcription regulatory factor β-catenin. FRZ proteins include FRZ1-10; these proteins have a wide regulatory functional range and play important roles not only at the cellular level, such as in embryo development, stem cell differentiation, and organogenesis, but also in maintaining tissue homeostasis, regeneration, plasticity, and restoration. The agonists, antagonists, and co-receptors of the WNT/FRZ signaling pathway are assumed to be potential targets for treating several types of serious diseases, such as cancer, neurodegenerative diseases, and osteoporosis. WNT/FRZ-related signaling pathways are complicated, and the effects of signaling pathway activation, their potential mechanisms, and the related molecules are unclear. Therefore, exploration of the specificity of the pathways and quantification of the reactions, system positioning, and downstream events are important; more comprehensive and in-depth studies are needed to shed light on these issues.

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    Basic properties of the demineralization of dentin matrix and preparation
    Xiong Hang, Xie Zhigang, Bao Jibo
    Inter J Stomatol. 2016, 43 (1):  90.  DOI: 10.7518/gjkq.2016.01.022
    Abstract ( 1477 )   HTML ( 8 )   PDF(pc) (1228KB) ( 1325 )   Save

    Osteoinductive bone graft substitutes with excellent biodegradability and biocompatibility are needed in bone defect treatment. Demineralized dentin matrix(DDM) is a kind of ideal bone substitute material. DDM comes from the non-functional teeth of humans. After demineralization, flushing, freeze-drying, and grinding, dentin is changed to DDM. Dentine and alveolar bone have very close chemistry, which means DDM presents strong osteogenic potential. Bone morphogenetic protein(BMP) is a type of growth factor that can induce new bone formation. DDM is formed via a complex of growth factors, such as BMP. DDM induction to form new bone yields no host immune rejection. DDM is an effective bone graft material with good biodegradability and biocompatibility. Two methods are available to prepare DDM: the traditional method and the supersonic acid-etching technique. Deminalization is traditionally effective and results in dentin with a complete structure. The particle size is a factor affecting osteogenesis effects. The majority of scholars believe that particle sizes of 75–500 μm ensure effective osteogenesis. The supersonic acid-etching technique can effectively create a surface structure that is beneficial for adsorption of bone cells and growth factors.

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    Clinical research progress on nasal floor repair of unilateral complete cleft lip
    Li Haipeng1, Wang Yujiang1, Ning Wenjie2, Zhu Zhinong1, Guo Meiling3
    Inter J Stomatol. 2016, 43 (1):  95.  DOI: 10.7518/gjkq.2016.01.023
    Abstract ( 997 )   HTML ( 3 )   PDF(pc) (1119KB) ( 936 )   Save

    Separation of the complete unilateral cleft lip and maxilla maxillary lateral fissure, contralateral mandibular rotation to the contralateral, and ipsilateral maxillary hypoplasia and relocation result in increased ipsilateral nostril flats, too-wide nasal floors, a collapsed nose, and nose base and sinking external rotation deformities. Most unilateral complete cleft lips are associated with the alveolar cleft and palate, and the nasal floor completely disappears. Nasal floor repair of unilateral complete cleft lips includes orthodontic treatment before surgery and surgery of the nasal floor. Simple preoperative orthodontics can reduce the nasal floor fracture gap and shorten the operation time. The rotating propulsion method presents simple operation procedures, less postoperative bleeding, a smooth early postoperative ride, and mucosal flap at the cleft lip edge. During the repair and restoration of the nasal bottom, all exposed wounds are eliminated and all useful organizations are retained. Using the mucosal flap of the inferior turbinate to repair the nasal floor of unilateral complete cleft lips can effectively increase the amount of tissue and reduce surgical tension; furthermore, wound healing and reduced complications are ensured. The benefits of orthodontic treatment before surgery require further study in China, and the therapeutic effects obtained from such a procedure are not stable. Therefore, new approaches should be continually explored to compensate for the deficiencies of traditional methods.

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    Advancement on the surgery-first approach for the correction of dento-maxillofacial deformities
    Tan Jianqin, Tang Zhenglong
    Inter J Stomatol. 2016, 43 (1):  99.  DOI: 10.7518/gjkq.2016.01.024
    Abstract ( 1076 )   HTML ( 6 )   PDF(pc) (1121KB) ( 1158 )   Save

    The surgery-first approach(SFA) for the correction of dento-maxillofacial deformities has attracted the attention of researchers and clinicians in recent years. The SFA proceeds with orthognathic surgery without presurgical orthodontic preparation. Moreover, orthodontic treatment is usually performed postoperatively during the SFA. Several clinical for the feasibility of the SFA and advantages, including rapid profile improvement studies provided a theoretical basis at the beginning of the treatment and great reduction in treatment supported its remarkable time. This article summarizes the advancements, case reports, preliminary clinical studies, clinical manipulations, and disadvantages of the SFA.

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    Research progress on human brown adipose cells
    Wang Xiaoling, Zhu Min
    Inter J Stomatol. 2016, 43 (1):  103.  DOI: 10.7518/gjkq.2016.01.025
    Abstract ( 1490 )   HTML ( 7 )   PDF(pc) (1205KB) ( 1647 )   Save

    White adipose cells(WAC) store energy through fat deposition in the form of triacylglycerol, whereas brown adipose cells(BAC) consume energy by transforming fat into heat through nonshivering heat production. BAC burn excess fat and sugar into heat, thereby preventing obesity. Beige adipose cells are brown-like WAC. Human BAC consist of beige adipose cells. Thus, the human BAC model is important to underst and the physiology and functions of BAC. Current studies on human BAC models are mainly derived from PAZ6 cells, BAC primary culture, human pluripotent stem cells, and mesenchymal stem cells. An ideal human BAC model contributes information on adipocytes and their metabolic mechanisms. This study established cell models derived from embryonic or adult fat or nonfat cells that can differentiate into BAC or beige adipose cells in adipose-induced media. The established BAC models lay the foundation on the prevention and treatment of obesity and related diseases.

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    Regulatory effect of macrophages in angiogenesis and tissue engineering
    Zheng Wenlong, Zou Duohong, Chen Qiaoer
    Inter J Stomatol. 2016, 43 (1):  108.  DOI: 10.7518/gjkq.2016.01.026
    Abstract ( 1245 )   HTML ( 10 )   PDF(pc) (1197KB) ( 2199 )   Save

    Macrophages are mainly divided into two subtypes: pro-inflammatory M1 and anti-inflammatory M2. During early acute inflammatory reaction, macrophages can secrete vascular endothelial growth factor, basic fibroblast growth factor, transforming growth factor-β1, interleukin, platelet-derived growth factor, matrix metalloproteinase, and numerous other substances. The seproteins can promote angiogenesis and structural reconstruction of defects. Macrophages coordinate with each other to promote the regeneration of blood vesselsand improve the efficiency of tissue regeneration. This coordination is not a simple antagonistic effect between anti-inflammatory and pro-inflammatory effects. In tissue engineering, scaffold, mesenchymal stem cells(MSC), and several types of cytokines can regulate macrophage phenotype conversion, which can promote angiogenesis by secreting cytokines and angiogenic growth factors at variousstages. MSC can secrete various cytokines to improve the hematopoietic microenvironment and promote the reconstruction of hematopoietic function after transplantation.

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    Effect of bone substitutes in oral implants on bone formation
    Wang Xiaona, Zhao Jinghui, Chu Shunli, Zhou Yanmin
    Inter J Stomatol. 2016, 43 (1):  113.  DOI: 10.7518/gjkq.2016.01.027
    Abstract ( 1523 )   HTML ( 14 )   PDF(pc) (1200KB) ( 1675 )   Save

    Bone graft substitutes are currently used in extraction site maintenance, alveolar ridge augmentation, and maxillary sinus floor augmentation. Hydroxylapatite, calcium phosphate, and bioactive glass are representative bone substitutes because of their biocompatibility, osteoconductibility, biodegradability, bone regeneration, and boneimplant contact ratios. The osteogenesis of bone substitutes depends on their morphology, structure, composition, pore size, and porosity. Combining two or more components in various proportions can produce new bone substitutes with excellent properties. For instance, the combined application of bone substitutes and platelet concentrates can promote the proliferation and differentiation of pre-osteoblasts and active osteoblasts, as well aspromote angiogenesis. In addition, bone substitutes combined with growth factors can promote new bone formation during early bone healing, acquire different levels of osseointegration and bone reconstruction, promote cell adhesion rate, and improve scaffold mechanics. Future studies should focus on optimizing the osteogenesis of bone substitutes and widening the applications of these substitutes in dental implantology.

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    Fluoride application for dental caries prevention and control in children and adolescents
    Feng Ruzhou, Liu Juan, Lü Changhai
    Inter J Stomatol. 2016, 43 (1):  118.  DOI: 10.7518/gjkq.2016.01.028
    Abstract ( 1372 )   HTML ( 28 )   PDF(pc) (1160KB) ( 1154 )   Save

    Fluoride is an essential trace element of the human body. Fluoride can prevent dental caries; its mechanisms in caries prevention mainly include enamel solubility reduction and enamel remineralization enhancement. Fluoride can also affect tooth morphology and inhibit bacterial metabolism and plaque formation. This element has been used to prevent dental caries in systemic and topical ways. Systemic fluoridation includes the following methods: water fluoridation, where appropriate fluoride concentrations are added to drinking water to prevent tooth decay; salt fluoridation, where fluoride is added to domestic salt to control and prevent dental caries; and milk fluoridation, where fluoride is added to milk as a vehicle to provide additional fluoride and prevent dental caries. Fluoride tablets and drops combine both local and systemic effects. Each systematic fluoridation method for caries prevention presents advantages and disadvantages. Different countries and areas should select the most appropriate systemic fluoridation method according to their situation. Topical fluoride use includes personal use of fluorides for caries prevention, such as fluoridated toothpastes, fluoride mouth wash, fluoride floss, and tea gargle. Many forms of professional fluoride agents are available, including fluoride solution, fluoride varnishes, fluoride gels, fluoride foam, fluoride-containing filling materials, and fluoride-releasing materials. Topical use of fluoride for caries prevention is effective; thus it is very commonly used in clinics and families.

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