Int J Stomatol

Inter J Stomatol ›› 2012, Vol. 39 ›› Issue (1): 10-11.doi: 10.3969/j.issn.1673-5749.2012.01.003

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Studies on topical toxicity of Benzocaine compound gel

Wei Baowei1, Liu Buming2, Chen Lili3, Liu Yuan1, Yao Shuhan3.   

  1. 1. Guangxi Institute of Traditional Medical & Pharmaceutical Sciences, Nanning 530022, China; 2. Key Laboratory, Guangxi Institute of Traditional Medical & Pharmaceutical Sciences, Nanning 530022, China; 3. Dept. of Out-patient, Guangxi Institute of Traditional Medical & Pharmaceutical Sciences, Nanning 530022, China
  • Received:2010-11-14 Revised:2011-09-26 Online:2012-01-01 Published:2012-01-01

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Abstract:

Objective To evaluate the topical irritation and sensitization of Benzocaine compound gel. Methods Irritation tests of rat oral mucosa, rabbit eyes, and skin hypersensitivity tests in guinea pigs were used, in accordance with the‘Guidance for Irritation, Sensitization and Hemolytic Tests for Chemicals’by the State Food and Drug Administration. Results By application of 3 g·kg-1 to rat oral mucosa, or 0.1 g to rabbit eyes, Benzocaine compound gel exhibited no irritation or other toxicity. No sensitization was found when 0.2 g of the gel was applied to the guinea pig skin. Conclusion Benzocaine compound gel is not irritative to oral mucosa, and does not cause skin allergy.

Key words: Benzocaine, gel, irritation, sensitization, rabbit, guinea pig, topical toxicity


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