再生性牙髓治疗在成人根尖发育不全恒牙应用的研究进展

doi:10.7518/gjkq.2023095

Abstract

Abstract:

Regenerative endodontic procedures have been used to treat infected immature permanent teeth in children and adolescents to achieve continued root development and dentin-pulp complex formation. Treating the infected teeth of adult patients with immature apices is challenging. Current treatments form physical barriers by apexification or apical barrier technique. Although teeth can be saved, they are devitalized and become susceptible to reinfections and fractures. With the development of tissue engineering and biomaterials, researchers have tried to save the immature permanent teeth of adults by regeneration. Here, the clinical efficacy of regenerative endodontic procedures is analyzed to explore whether they should be developed for dental pulp and/or dentin regeneration in adults with immature apices.

Key words: regenerative endodontic procedures, permanent teeth, immature apices, periapical periodontitis

CLC Number:

R 781

TrendMD:

Hu Jia,Wang Xiuqing,Lu Guoying,Huang Xiaojing.. Regenerative endodontic procedures for permanent tooth with immature apices in adult patients[J].Int J Stomatol, 2023, 50(6): 686-695.

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References 59

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作者	研究类型（病例数）	年龄/岁	牙位	支架	根管预备	症状消失	根尖暗影	牙髓活力		随访时间/月
作者	研究类型（病例数）	年龄/岁	牙位	支架	根管预备	症状消失	根尖暗影	冷测	电活力	随访时间/月
Machut等^[16]	病例报告（2）	45、42	23	PRF+GP	机械预备	是	缩小	-	-	6
Brizuela等^[12]	随机对照（18/36）*	16~58	前牙/前磨牙	BC+ UC-MSCs	机械预备	是	愈合/缩小（100%）^▲	+（56%）	+（50%）	12
El-Kateb等^[21]	随机对照（18）*	20~34	前牙	BC	#30/#50	是	愈合/缩小（100%）^▲	+（83%）	+（77%）	12
Arslan等^[19]	随机对照（26/46）*	18~30	单根牙	BC	#45~#80	是	愈合/缩小（92.3%）^▲	NM	+（50%）	12
Nageh等^[23]	临床研究（15）	18~40	11/21	BC+PRF	#60~#80	是	愈合	+（60%）	+（100%）	12
Saoud等^[24]	病例报告（7）	8~21	前牙/磨牙	BC	#25~#40	是	愈合/缩小（100%）^▲	-	-	8~26
Saoud等^[18]	病例报告（1）	23	12	BC	#35	是	缩小	-	-	12
Paryani等^[17]	病例报告（2）	11、14	11/21	BC	#60	是	愈合	NM	+（50%）	18、22
Shah等^[15]	临床研究（18）	15~76	前牙/磨牙	BC	#25~#30	是	愈合/缩小（100%）^△	-	-	6~36

作者	研究类型	病例数	年龄/岁	牙位	再治疗	牙根发育*	支架	机械预备	症状消失	根尖暗影	牙根变化	牙髓活力	随访时间/月
Nosrat等^[25]	病例报告	1	18	21	是	9	BC+PRF	少量	是	愈合	根尖闭合	-	12
Neelamurthy等^[26]	临床研究	9	18~35	单根牙	否	8~9	BC	无	是	愈合/缩小（100%）	根尖闭合/牙根发育（66.7%）	+（1）	10
Gavi?o Ordu?a等^[27]	病例报告	3	21~35	前牙	是（1）	8~9	BC+PRP	少量	是	愈合	根尖闭合（1）/根长少量增加（1）	NM	50
Zhujiang等^[28]	病例报告	1	20	37	否	8	BC+rh-PDGF-BB	少量	是	愈合	根尖闭合	+	15
Nevins等^[29]	病例报告	4	28~48	前牙/前磨牙	是	9	BC	少量	是	缩小	根尖闭合（1）	NM	12
Saoud等^[30]	病例报告	1	26	21	是	9	BC	#60	是	缩小	根尖闭合，管壁增厚	-	13
Saoud等^[18]	病例报告	1	23	11	否	9	BC	#100	是	缩小	根尖闭合，管壁增厚	-	12

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Regenerative endodontic procedures for permanent tooth with immature apices in adult patients

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