Int J Stomatol

Inter J Stomatol ›› 2016, Vol. 43 ›› Issue (6): 645-650.doi: 10.7518/gjkq.2016.06.006

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Clinical significance of serum squamous cell carcinoma antigens in Uyghur patients with oral squamous cell carcinoma

Liu Pan, Duolikun?Wufuer, Cai Zhigang, Sun Jian   

  1. 1. Dept. of Oral and Maxillofacial Surgery, People’s Hospital of Xinjiang Uyghur Autonomous Region, Urumqi 830001, China; 2. Dept. of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital, Peking University, Beijing 100081, China; 3. Dept. of Oral and Maxillofacial Surgery, The Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China
  • Online:2016-11-01 Published:2016-11-01

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Abstract: Objective This study investigates the expression of squamous cell carcinoma antigen(SCC-Ag) levels in patients with Uyghur oral squamous cell carcinoma(OSCC). Methods Serum SCC-Ag levels were measured in 90 Uyghur patients with OSCC(OSCC group), 90 Uyghur patients with other oral malignant tumors(oral malignant tumor except OSCC group), 101 Uyghur patients with oral benign tumors(benign tumor group), and 120 healthy Uyghur people(healthy group). SCC-Ag levels were measured in 60 OSCC cases and 60 cases of oral malignant tumor except OSCC before and after treatment. The significance of SCC-Ag in the diagnosis and treatment of OSCC was analyzed. Results SCC-Ag levels in OSCC group were significantly higher than in oral malignant tumor except OSCC group(P=0.002), benign tumor group(P=0.001), and healthy group(P=0.001). Serum SCC-Ag positive rate in OSCC group was 43.3% (39/90) and was significantly higher compared with the other three groups(P=0.000 1). SCC-Ag expression was higher in preoperative OSCC group in late TNM stage compared with patients in early TNM stage(P<0.05). Preoperative and postoperative patients who received radiation and chemotherapy treatment were further classified into the recurrence group and non-recurrence group, the difference in SCC-Ag levels between groups was statistically significant(P<0.05). The difference between SCC-Ag levels in groups with squamous carcinoma before and after surgical, radiation, and chemotherapy treatment was statistically significant(P<0.01). However, the curative effect of SCC-Ag levels in oral malignant tumor except OSCC group was not statistically significant(P>0.05). Conclusion Serum SCC-Ag levels were not highly sensitive in Uyghur patients with early-stage OSCC. However, SCC-Ag has clinical significance in the evaluation of curative effect as a predictor of tumor recurrence.

Key words: oral squamous cell carcinoma, squamous cell carcinoma antigen, biomarker, surgery, chemoradiotherapy


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