Int J Stomatol

Int J Stomatol ›› 2025, Vol. 52 ›› Issue (5): 677-683.doi: 10.7518/gjkq.2025053

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Research progress on the relationship between periodontitis and non-alcoholic fatty liver disease

Huan Li1(),Shaozhong Yuan1,2()   

  1. 1.Shanxi Medical University School and Hospital of Stomatology, Taiyuan 030001, China
    2.Dept. of Oral Medicine, Shanxi Provincial People’s Hospital, Shanxi Medical University, Taiyuan 030012, China
  • Received:2024-06-25 Revised:2024-08-31 Online:2025-09-01 Published:2025-08-27
  • Contact: Shaozhong Yuan E-mail:913314328@qq.com;yszrmyy@163.com

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Abstract:

Non-alcoholic fatty liver disease (NAFLD) is a disease characterized by the accumulation of liver cell fat, and periodontitis is a chronic inflammation of the supporting tissues surrounding the teeth. Previous studies found a close correlation between NAFLD and periodontitis, but the interaction mechanisms are still unclear. Increasing evidence shows that periodontitis, accompanied by oral inflammation and pathological changes in the microbiome, induces intestinal dysbiosis, and changes in the intestinal microbiome may also play a role in the pathogenesis of NAFLD. This review will focus on the epidemiology, possible mechanisms, and treatment of NAFLD and periodontitis, expecting to provide a new NAFLD prevention strategy from a dental science viewpoint.

Key words: periodontitis, non-alcoholic fatty liver disease, oral-gut-liver axis, Porphyromonas gingivalis, correlation

CLC Number: 

  • R781.4

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