Int J Stomatol

Int J Stomatol ›› 2025, Vol. 52 ›› Issue (3): 317-322.doi: 10.7518/gjkq.2025042

• Periodontitis • Previous Articles    

Research progress on the role and mechanism of competitive endogenous RNA in periodontitis

Xingli Fan(),Le Pan,Jiayuan Zhao,Qiumeng Xiang,Qilin Chen()   

  1. Dept. of Stomatology, Taihe Hospital of Hubei University of Medicine, Institute of Oral Diseases, School of Stomatology, Hubei University of Medicine, Shiyan 442000, China
  • Received:2024-04-13 Revised:2024-06-30 Online:2025-05-01 Published:2025-04-30
  • Contact: Qilin Chen E-mail:1095328367@qq.com;drchenqilin@126.com
  • Supported by:
    Hubei Provincial Health Commission Research Project(WJ2021M049);Guiding Project of Scientific Research Plan of Hubei Provincial Department of Education in 2022(B2022499)

RichHTML

0

PDF (PC)

3

Abstract:

Research has found that competitive endogenous RNA (ceRNA) regulates the progression of periodontitis by modulating the transcriptional response of inflammation-related mediators. ceRNA, including long noncoding RNA, circular RNA, and messenger RNA, can bind to microRNA to form a ceRNA network, regulate the expression of downstream target genes, and influence the occurrence and development of periodontitis. This article summarizes the role and mechanism of ceRNA in regulating the occurrence and development of periodontitis that have been verified by experimental evidence. This article also reviews the research progress in inhibiting and promoting the occurrence and development of periodontitis, and provides new ideas for future research on periodontitis.

Key words: competitive endogenous RNA, periodontitis, microRNA, long non-coding RNAs, circular RNA

CLC Number: 

  • R781.4

TrendMD: 
1 Billings M, Holtfreter B, Papapanou PN, et al. Age-dependent distribution of periodontitis in two countries: findings from NHANES 2009 to 2014 and SHIP-TREND 2008 to 2012[J]. J Clin Periodontol, 2018, 45(): S130-S148.
2 Preshaw PM, Bissett SM. Periodontitis and diabetes[J]. Br Dent J, 2019, 227(7): 577-584.
3 Larsson L, Kavanagh NM, Nguyen TVN, et al. Influence of epigenetics on periodontitis and peri-implantitis pathogenesis[J]. Periodontol 2000, 2022, 90(1): 125-137.
4 Salmena L, Poliseno L, Tay Y, et al. A ceRNA hypothesis: the rosetta stone of a hidden RNA language[J]. Cell, 2011, 146(3): 353-358.
5 Abbasifard M, Kamiab Z, Bagheri-Hosseinabadi Z, et al. The role and function of long non-coding RNAs in osteoarthritis[J]. Exp Mol Pathol, 2020, 114: 104407.
6 Sánchez-Muñoz F, Martínez-Coronilla G, Leija-Montoya AG, et al. Periodontitis may modulate long-non coding RNA expression[J]. Arch Oral Biol, 2018, 95: 95-99.
7 Lin LH, Zhou GS, Chen P, et al. Which long noncoding RNAs and circular RNAs contribute to inflammatory bowel disease[J]. Cell Death Dis, 2020, 11(6): 456.
8 Liu JY, Chen B, Bao J, et al. Macrophage polarization in periodontal ligament stem cells enhanced periodontal regeneration[J]. Stem Cell Res Ther, 2019, 10(1): 320.
9 Huang NN, Li CX, Sun WJ, et al. Long non-coding RNA TUG1 participates in LPS-induced periodontitis by regulating miR-498/RORA pathway[J]. Oral Dis, 2021, 27(3): 600-610.
10 Han Y, Wang F, Shao LQ, et al. LncRNA TUG1 mediates lipopolysaccharide-induced proliferative inhibition and apoptosis of human periodontal ligament cells by sponging miR-132[J]. Acta Biochim Biophys Sin, 2019, 51(12): 1208-1215.
11 Chen H, Lan ZD, Li QM, et al. Abnormal expression of long noncoding RNA FGD5-AS1 affects the development of periodontitis through regulating miR-142-3p/SOCS6/NF‑κB pathway[J]. Artif Cells Nanomed Biotechnol, 2019, 47(1): 2098-2106.
12 Yu M, Chi CY. lncRNA FGD5-AS1 and miR-130a can be used for prognosis analysis of patients with chronic periodontitis[J]. Biomed Res Int, 2021, 2021: 8544914.
13 喻茂文, 柳建磊, 汤洪波, 等. LINC00963靶向miR-525-5p调控LPS诱导的牙周膜细胞损伤的机制研究[J]. 实用口腔医学杂志, 2022, 38(4): 455-460.
Yu MW, Liu JL, Tang HB, et al. The mechanizm of LINC00963 targeting miR-525-5p in the regulation of LPS-induced periodontal ligament cell damage[J]. J Pract Stomatol, 2022, 38(4): 455-460.
14 Li Q, Hu ZP, Yang F, et al. Circ_0066881 targets miR-144-5p/RORA axis to alleviate LPS-induced apoptotic and inflammatory damages in human perio-dontal ligament cells[J]. Innate Immun, 2022, 28(5): 164-173.
15 Zhao XQ, Ao CB, Yan YT. The circular RNA circ_0099630/miR-940/receptor-associated factor 6 regulation cascade modulates the pathogenesis of perio-dontitis[J]. J Dent Sci, 2022, 17(4): 1566-1576.
16 Wang L, Li YL, Hong FF, et al. Circ_0062491 alleviates LPS-induced apoptosis and inflammation in periodontitis by regulating miR-498/SOCS6 axis[J]. Innate Immun, 2022, 28(5): 174-184.
17 Pan JX, Zhao L, Liu J, et al. Inhibition of circular RNA circ_0138959 alleviates pyroptosis of human gingival fibroblasts via the microRNA-527/caspase-5 axis[J]. Bioengineered, 2022, 13(1): 1908-1920.
18 Fang Y, Tian SW, Pan YT, et al. Pyroptosis: a new frontier in cancer[J]. Biomed Pharmacother, 2020, 121: 109595.
19 Li W, Zhang Z, Li YZ, et al. Abnormal hsa_circ_0003948 expression affects chronic periodontitis development by regulating miR-144-3p/NR2F2/PTEN signaling[J]. J Periodontal Res, 2022, 57(2): 316-323.
20 Du WW, Wang L, Liao Z, et al. Circ_0085289 alleviates the progression of periodontitis by regulating let-7f-5p/SOCS6 pathway[J]. Inflammation, 2021, 44(4): 1607-1619.
21 Wang J, Du CC, Xu LL. Circ_0081572 inhibits the progression of periodontitis through regulating the miR-378h/RORA axis[J]. Arch Oral Biol, 2021, 124: 105053.
22 Wang ZH, Wang DZ, Guo S, et al. Long noncoding RNA distal-less homeobox 2 antisense 1 restrains inflammatory response and apoptosis of periodontal ligament cells by binding with microRNA-330-3p to regulate Ro60, Y RNA binding protein[J]. Arch Oral Biol, 2022, 133: 105298.
23 Wang SW, Duan Y. LncRNA OIP5-AS1 inhibits the lipopolysaccharide-induced inflammatory response and promotes osteogenic differentiation of human periodontal ligament cells by sponging miR-92a-3p[J]. Bioengineered, 2022, 13(5): 12055-12066.
24 Liu W, Zheng YY, Chen B, et al. LncRNA papillary thyroid carcinoma susceptibility candidate 3 (PTCSC3) regulates the proliferation of human periodontal ligament stem cells and toll-like receptor 4 (TLR4) expression to improve periodontitis[J]. BMC Oral Health, 2019, 19(1): 108.
25 Wang CL, Gong JX, Li D, et al. circ_0062491 alleviates periodontitis via the miR-142-5p/IGF1 axis[J]. Open Med, 2022, 17(1): 638-647.
26 Cheng L, Fan YL, Cheng J, et al. Long non-coding RNA ZFY-AS1 represses periodontitis tissue inflammation and oxidative damage via modulating micro-RNA-129-5p/DEAD-Box helicase 3 X-linked axis[J]. Bioengineered, 2022, 13(5): 12691-12705.
27 Zhang L, Lv H, Cui YX, et al. The role of long non-coding RNA (lncRNA) nuclear paraspeckle assembly transcript 1 (NEAT1) in chronic periodontitis progression[J]. Bioengineered, 2022, 13(2): 2336-2345.
28 Zhang CR, Xue PX, Ke JG, et al. Development of ferroptosis-associated ceRNA network in periodontitis[J]. Int Dent J, 2023, 73(2): 186-194.
29 袁帅, 杜样, 汪璐璐, 等. 尼古丁对人牙周膜细胞长链非编码RNA NEAT1表达的影响[J]. 医学研究生学报, 2017, 30(3): 240-244.
Yuan S, Du Y, Wang LL, et al. The effects of Nicotine on the expression of lncRNA NEAT1 in human periodontal ligament cells[J]. J Med Postgrad, 2017, 30(3): 240-244.
30 Chen QC, Cao M, Ge HY. Knockdown of MALAT1 inhibits the progression of chronic periodontitis via targeting miR-769-5p/HIF3A axis[J]. Biomed Res Int, 2021, 2021: 8899863.
31 Deng WJ, Wang XL, Zhang J, et al. Circ_0138959/miR-495-3p/TRAF6 axis regulates proliferation, wound healing and osteoblastic differentiation of periodontal ligament cells in periodontitis[J]. J Dent Sci, 2022, 17(3): 1125-1134.
32 Wang J, Wang ZN, Huang M, et al. Circ_0099630 participates in SPRY1-mediated repression in perio-dontitis[J]. Int Dent J, 2023, 73(1): 136-143.
33 He LL, Liu CC, Liu YY, et al. Circular RNA hsa_circ_0084054 promotes the progression of pe-riodontitis with diabetes via the miR-508-3p/PTEN axis[J]. J Periodontal Res, 2023, 58(4): 827-840.
34 Wangzhou KX, Gong L, Liu C, et al. LncRNA MAFG-AS1 regulates human periodontal ligament stem cell proliferation and Toll-like receptor 4 expression[J]. Oral Dis, 2020, 26(6): 1302-1307.
35 Yu BH, Hu JH, Li Q, et al. CircMAP3K11 contri-butes to proliferation, apoptosis and migration of human periodontal ligament stem cells in inflammatory microenvironment by regulating TLR4 via miR-511 sponging[J]. Front Pharmacol, 2021, 12: 633353.
36 Wang F, Chen X, Han Y, et al. circRNA CDR1as regulated the proliferation of human periodontal ligament stem cells under a lipopolysaccharide-induced inflammatory condition[J]. Mediators Inflamm, 2019, 2019: 1625381.
[1] Tianyuan Li,Tongxin Zhu,Qing Liu,Yingchun Dong,Bin Chen. Clinical efficacy of mesenchymal stem cells on periodontal regeneration: a systematic review and meta-analysis [J]. Int J Stomatol, 2025, 52(3): 296-307.
[2] Mengyao Bie,Jieyu Zhou,Yafei Wu,Lei Zhao. Research progress into the effects of Porphyromonas gingivalis on regulatory cell death and phenotypic switching of vascular smooth muscle cells [J]. Int J Stomatol, 2025, 52(3): 308-316.
[3] Jing Li,Jian Kang. Use of regenerated materials in periodontal minimally invasive surgery [J]. Int J Stomatol, 2025, 52(2): 161-168.
[4] Xiaoyue Zhang,Shuze Chen,Jieyu Zhou,Lei Cheng,Lei Zhao. Studying how Fusobacterium nucleatum affects the intestinal epithelial barrier model in vitro via the ferroptosis pathway [J]. Int J Stomatol, 2025, 52(2): 183-194.
[5] Liangjun Zhong. Application of digital technology in the treatment of advanced periodontitis [J]. Int J Stomatol, 2025, 52(1): 1-10.
[6] Shouzheng Cheng,Taiwen Li,Lei Zhao. Research progress on the correlation between serum amyloid A and periodontitis [J]. Int J Stomatol, 2025, 52(1): 117-122.
[7] Mengjie Chen,Wenhua Xu,Qingqing Liu,Yudan Kang,Rong Liu,Lilei Zhu. Correlation analysis between the systemic immune-inflammatory index and graded diagnosis in patients with perio-dontitis [J]. Int J Stomatol, 2024, 51(6): 706-712.
[8] Rui Chen,Zhen Fan,Chunbo Hao. Research progress of absent in melanoma 2 inflammasome in periodontitis and diabetes [J]. Int J Stomatol, 2024, 51(6): 763-771.
[9] Hongchen Mao,Zheng Wang,Deqin Yang. Advances in the role of outer membrane vesicles of Porphyromonas gingivalis in oral diseases and its mechanism [J]. Int J Stomatol, 2024, 51(5): 608-615.
[10] Meiyao Qi,Xingying Qi,Xinyi Zhou,Zhen Tan,Quan Yuan. Therapeutic effect of cannabidiol combined with minocycline on periodontitis [J]. Int J Stomatol, 2024, 51(4): 392-400.
[11] Mengjie Chen, Xiaole Liu, Lilei Zhu. The effect of supportive periodontal therapy on blood cell indicators in patients with periodontitis： a retrospective study [J]. Int J Stomatol, 2024, 51(4): 401-405.
[12] Yu Ma, Yu Zuo, Jianhua Liu. Meta-analysis of the efficacy of antimicrobial photodynamic therapy and systemic antimicrobial drug as an adjunct treatment for periodontitis [J]. Int J Stomatol, 2024, 51(4): 406-415.
[13] Shili Liu, Lei Zhao. Progress of research on the correlation between periodontitis and heart failure [J]. Int J Stomatol, 2024, 51(4): 425-432.
[14] Zaimu Yang,Pei Cao,Zhenhua Liu,Qingxian Luan. Correlation study of plasma cell-free extra-mitochondrial mitochondria DNA and periodontitis clinical parameters [J]. Int J Stomatol, 2024, 51(3): 288-295.
[15] Yuhong Ma,Lei Zhao. Process and progress in the clinical research of minimally invasive non-operative periodontal therapy technology [J]. Int J Stomatol, 2024, 51(2): 227-232.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!