Int J Stomatol

Inter J Stomatol ›› 2007, Vol. 34 ›› Issue (04): 259-261.

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Research progress of matrix extracellular phosphoglycoprotein

WEI Xi, LIU Lu, LING Jun-qi.   

  1. Dept. of Operative D entistry and Endodontics, H ospital of Stom atology, G uanghua School of Stom atology, Sun Y at-Sen U niversity, G uangzhou 510055, China
  • Online:2007-07-20 Published:2007-07-20

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Abstract:

Matrix extracellular phosphoglycoprotein（MEPE） is encoded by the gene m apping to the hum an chromosome 4q21.1. High expression is in the human oncogenic hypophosphatemic osteomalacia tumor. MEPE is considered to be a potential phosphatonins and inhibitor of mineralization. MEPE, referred to as minhibins, is identified in mature osteoblasts and osteocytes with a regulatory role in bone form ation and skeletal m ineralization. Moreover, based on refined gene mapping and expression by odontoblasts, MEPE is also thought to be a strong candidate gene for human dental structural diseases, including amelogenesis imperfecta, dentinogenesis imperfecta type Ⅱ，Ⅲ and dentin dysplasia type Ⅱ.

Key words: matrix extracellular phosphoglycoprotein, mineralization, cell proliferation, cell differentiation


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