Int J Stomatol

Int J Stomatol ›› 2024, Vol. 51 ›› Issue (6): 749-755.doi: 10.7518/gjkq.2024092

• Reviews • Previous Articles    

Research progress on the mechanism of ribosomal protein L5 in Diamond-Blackfan anemia associated with cleft lip and palate

Wanqiong Zhang(),Qian Zheng(),Zhonglin Jia   

  1. State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Cleft Lip and Palate Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2023-12-04 Revised:2024-06-25 Online:2024-11-01 Published:2024-11-04
  • Contact: Qian Zheng E-mail:2733318673@qq.com;zq652@163.com
  • Supported by:
    West China Hospital of Stomatology Sichuan University Crossover Project(RD-03-202301)

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Abstract:

Ribosomal protein L5 (RPL5) is a part of the large subunit of the ribosome. Diamond-Blackfan anemia in patients who carry mutations in the RPL5 gene is associated with various malformations, including craniofacial malformations such as cleft lip and palate and somatic malformations such as heart defects. In the case of RPL5 mutation leading to defects in ribosome organisms, the mechanism by which cleft lip and palate occurs is still poorly understood. This study reviews recent research on RPL5 and discusses the possible mechanisms by which mutated RPL5 occurs in cleft lip and palate.

Key words: ribosomal protein L5, Diamond-Blackfan anemia, cleft lip and palate, P53, ribosomal protein

CLC Number: 

  • Q75

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