Int J Stomatol

Int J Stomatol ›› 2024, Vol. 51 ›› Issue (2): 176-186.doi: 10.7518/gjkq.2024036

• Original Articles • Previous Articles     Next Articles

A meta-analysis of the efficacy between bioceramic material iRoot BP Plus and mineral trioxide aggregate in pulpo-tomy

Yanduo Yang(),Hong Chen,Zuda Xu,Yuan Zhao()   

  1. School of Stomatology, Lanzhou University, Lanzhou 730000, China
  • Received:2023-05-09 Revised:2023-12-20 Online:2024-03-01 Published:2024-03-11
  • Contact: Yuan Zhao E-mail:Yangyd21@lzu.edu.cn;zhaoy@lzu.edu.cn
  • Supported by:
    Research Projects in the Healthcare Industry in Gansu Province(GSWSKY2023-33);Lanzhou University Medical Education Innovation and Development Project(Lzuyxcx-2022-166)

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Abstract:

Objective This study aims to compare the efficacy of iRoot BP Plus and MTA as pulp capping agents for vital pulp therapy. Methods Randomized controlled trials (RCTs) of iRoot BP Plus and MTA in the treatment of pulpo-tomy were searched in PubMed, Web of Science, Cochrane Library, CNKI, Wanfang, and VIP databases from the establishment to March 2023. Two members conducted independent screening according to the inclusion and exclusion criteria. The outcome indicators included clinical success rate, pulp capping operation time, dentin bridge formation rate, and tooth discoloration rate. The Cochrane bias risk assessment tool was used to evaluate the quality of the literature, and Stata 15.0 was used for meta-analysis. Results A total of 18 RCTs were included. The results of meta-analysis showed 1) no significant difference in the clinical success rate between iRoot BP Plus group and MTA group at 3, 6, and 12 months after the operation (P> 0.05). 2) The operation time of iRoot BP Plus was significantly shorter than that of MTA (P<0.05). 3)The formation rate of dentin calcified bridge in the iRoot BP Plus group was higher than that in the MTA group at 3 months after the operation (P<0.05). 4) At the last follow-up, the tooth discoloration rate of the iRoot BP Plus group was significantly lower than that of the MTA group (P<0.05). Conclusion The clinical success rate of iRoot BP Plus for pulpotomy is similar to that of MTA, but it has shorter pulp-capping operation time and lower probability of tooth discoloration than MTA pulp capping.

Key words: meta-analysis, pulpotomy, bioceramic material, iRoot BP Plus, mineral trioxide aggregate, pulp capping material

CLC Number: 

  • R781.05

TrendMD: 

Tab 1

Pubmed retrieval style"

序号检索式
#1“pulpotomy”[Mesh Terms]
#2“vital pulp therapy”[Title/Abstract] OR“pulp capping”[Title/Abstract]
#3#1 OR #2
#4(“iRoot BP Plus”[Title/Abstract] OR “iRoot BP”[Title/Abstract] OR “Endosequence Root Repair Material”[Title/Abstract]) OR (“MTA”[Title/Abstract] OR “Mineral Trioxide Aggregate”[Title/Abstract] OR “bioceramic”[Title/Abstract] OR “MTA cement”[Title/Abstract] OR “aggregate ProRoot”[Title/Abstract] OR “ProRoot MTA”[Title/Abstract])
#5“randomized controlled trial”[Title/Abstract] OR “randomized controlled study”[Title/Abstract] OR “clinical trial”[Title/Abstract] OR “clinical study”[Title/Abstract]
#6#3 AND #4 AND #5

Fig 1

Flow chart of literature screening"

Tab 2

Basic informations of the included literatures"

作者发表年随访时间/月随机方法样本数/例年龄/岁患牙类型露髓原因活髓切断术式是否行橡皮障隔离术结局指标
iRoot BP PlusMTAiRoot BP PlusMTA
张海龙等[13]20223、6、12③30306~177~18年轻恒牙外伤部分冠髓切断术是①②④
梁秋娟等[14]20183、6④8080——年轻恒牙深龋全部冠髓切断术否①
方溢云等[15]202112③4040

14.83.6

13.23.4

成熟恒牙深龋全部冠髓切断术是①④
赵燕霞等[16]202112②5051

9.131.2

9.191.6

年轻恒牙外伤不明是①③④
翟利云[17]20193、6②2525

10.191.71

10.321.62

年轻恒牙深龋不明不明①②④
雷金霞等[18]20193、6②40408~108~10年轻恒牙外伤全部冠髓切断术否①③④
Kiranmayi等[19]20223、6、12①30304~94~9乳磨牙深龋全部冠髓切断术是①
杜姣等[20]20203、6、12①45473~73~7乳磨牙深龋全部冠髓切断术是①
钱芳等[21]20213、6、12①4545——成熟恒牙深龋部分冠髓切断术是①
王菲菲等[22]20223、6、12②7574

7.241.06

7.181.02

乳磨牙深龋全部冠髓切断术是①②④
王爽等[23]20223、6、12①26263~83~8乳磨牙深龋全部冠髓切断术是①
杨京宇等[24]20223、6、12②3535

6.611.25

6.421.16

乳磨牙深龋全部冠髓切断术否①④
向珊珊等[25]20193、6、12①2020

6.271.23

6.581.19

乳磨牙深龋全部冠髓切断术否①②
张小芳等[26]20226、12①41417~117~11年轻恒牙外伤全部冠髓切断术是①④
刘鹏等[27]20226②40503~83~8乳磨牙深龋全部冠髓切断术是①
李文文等[28]202212①7173

9.311.06

9.591.12

年轻恒牙外伤不明是①②③④
严恒[29]202012①23207~117~11年轻恒牙龋或外伤部分冠髓切断术是①④
钱锟等[30]202212①222116~5921~55成熟恒牙深龋不明是①④

Tab 3

Risk bias assessment included in the literature"

纳入文献随机化过程中的偏倚干预分配干预依从结局数据缺失偏倚结局测量偏倚结果选择性报告偏倚
张海龙等[13]①②②③③③
梁秋娟等[14]①①①③③②
方溢云等[15]①①①③③②
赵燕霞等[16]②①②③③②
翟利云[17]②①②②③③
雷金霞等[18]②②②③③③
Kiranmayi等[19]③③③②③③
杜姣等[20]③②②②③③
钱芳等[21]③②②③③③
王菲菲等[22]②②②②③③
王爽等[23]③③③③③③
杨京宇等[24]②②②③③③
向珊珊等[25]③②②③③③
张小芳等[26]③②②③③③
刘鹏等[27]②②②②③③
李文文等[28]③②②②③②
严恒[29]③②②③③③
钱锟等[30]③③③③③③

Fig 2

Comparison of the total success rate between the iRoot BP Plus group and the MTA group"

Fig 3

Funnel charts comparing the total success rate between the iRoot BP Plus group and the MTA group"

Fig 4

Subgroup analysis of the comparison of the total success rate between the iRoot BP Plus group and the MTA group at 12 months after operation"

Fig 5

Comparison of pulp-capping operation time between the iRoot BP Plus group and the MTA group"

Fig 6

Comparison of the formation rates of dentin calcified bridge between the iRoot BP Plus group and the MTA group at 3 months follow-up"

Fig 7

Comparison of the tooth discoloration rates between the iRoot BP Plus group and the MTA group"

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