Int J Stomatol

Int J Stomatol ›› 2024, Vol. 51 ›› Issue (1): 10-20.doi: 10.7518/gjkq.2024019

• Oral Oncology • Previous Articles     Next Articles

The new strategies of antimetabolic therapy of cancers based on antiporter of cystine and glutamate

Wang Miao(),Meng Wanrong,Li Longjiang()   

  1. State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2023-04-08 Revised:2023-07-30 Online:2024-01-01 Published:2024-01-10
  • Contact: Longjiang Li E-mail:wangm6360@163.com;muzili63@163.com
  • Supported by:
    National Natural Science Foundation of China(81972538)

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Abstract:

Metabolism reprogram is one of the major characteristics of malignant cancer. It promotes survival of tumor cells and launches the malignant progression of cancers under the nutrition-deficient tumor milieu. Several recent studies have revealed that the antiporter of cystine and glutamine, system Xc–, is a key target of ferroptosis and also impairs flexibility of tumor metabolism remolding and promotes dependency on glucose. This finding indicates that interfering glucose uptake and glucose metabolism are potential methods of treating system Xc– overexpression cancers. This review summarizes the expressional regulation and metabolic functions of system Xc–, thereby paving a new avenue for the antimetabolic therapy of cancers.

Key words: metabolism reprogram, antiporter of cystine and glutamate, glutamine, reduced nicotinamide adenine dinucleotide phosphate

CLC Number: 

  • R782

TrendMD: 

Fig 1

Transcriptional regulation of xCT"

Fig 2

Epigenetic regulation of xCT"

Fig 3

Regulation of CD98 expression"

Fig 4

The relationship between system Xc- and cell metabolism, including glutamine metabolism, NADPH metabolism and glucose metabolism"

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