Int J Stomatol

Int J Stomatol ›› 2024, Vol. 51 ›› Issue (1): 74-81.doi: 10.7518/gjkq.2024009

• Reviews • Previous Articles     Next Articles

Research progress on the antibacterial mechanism of oral local anesthetics

Tan Yongzhen(),Liang Xinhua()   

  1. State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Alveolar Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2023-02-08 Revised:2023-05-05 Online:2024-01-01 Published:2024-01-10
  • Contact: Xinhua Liang E-mail:tyz7965566@163.com;lxh88866@scu.edu.cn
  • Supported by:
    Interdisciplinary Innovation Project of West China Hospital of Stomatology, Sichuan University(RD-03-202004)

RichHTML

10

PDF (PC)

246

Abstract:

Local anesthetic is a kind of drug commonly used in oral outpatient operations. It has anesthetic and analgesic effects, and it can alleviate the pain of patients and facilitate treatment. Many studies have shown that local anesthetics have antibacterial effects, and they can effectively inhibit the growth of various bacteria and fungi. In this paper, the antibacterial effects of local anesthetics commonly used in dentistry (lidocaine, bupivacaine, ropivacaine, articaine, etc.) were summarized, and their molecular mechanisms were discussed (including changes in cell wall and membrane permeability, direct damage to cell membranes, inhibition of protein and genetic material synthesis, inhibition of cell respiration, etc.). The interaction with other drugs (antibiotics, epinephrine, opioids, etc.) also were studied. This work will be helpful in the selection of local anesthetics in oral clinics and the prevention and control of infection.

Key words: local anesthetics, antibacterial, dentistry

CLC Number: 

  • R78

TrendMD: 

Tab 1

Antibacterial effect of partial oral local anesthetics"

菌种丙胺卡因地布卡因丁卡因苯佐卡因利丙双卡因乳膏
金黄色葡萄球菌+NNN+
化脓性链球菌NNNN+
血链球菌+NNNN
耐甲氧西林金黄色葡萄球菌NNNN+
黏性放线菌+NNNN
巨大芽孢杆菌+N+NN
铜绿假单胞菌+++N+
奈瑟氏菌+NNNN
大肠埃希菌+++N+
产气克雷伯菌N+N+N
牙龈卟啉单胞菌+NNNN
具核梭杆菌+NNNN
白色念珠菌+NNNN
1 Booij LHDJ. Pain and impulse conduction[M]//Baart J, Brand H. Local anaesthesia in dentistry. Cham: Springer International Publishing, 2017: 1-17.
2 Boyce RA, Kirpalani T, Mohan N. Updates of topical and local anesthesia agents[J]. Dent Clin North Am, 2016, 60(2): 445-471.
3 Salgado-Peralvo AO, Peña-Cardelles JF, Kewalramani N, et al. Is antibiotic prophylaxis necessary before dental implant procedures in patients with orthopaedic prostheses? A systematic review[J]. Antibiotics (Basel), 2022, 11(1): 93.
4 Dammling C, Abramowicz S, Kinard B. Current concepts in prophylactic antibiotics in oral and ma-xillofacial surgery[J]. Oral Maxillofac Surg Clin North Am, 2022, 34(1): 157-167.
5 Szabó Z, Szentkirályi É, Kovács T, et al. Antibacterial effect of local anaesthetics[J]. Orv Hetil, 2021, 162(5): 171-176.
6 Lagadinou M, Onisor MO, Rigas A, et al. Anti-microbial properties on non-antibiotic drugs in the era of increased bacterial resistance[J]. Antibiotics (Basel), 2020, 9(3): 107.
7 Wang YH, Wang DR, Liu JY, et al. Local anesthesia in oral and maxillofacial surgery: a review of current opinion[J]. J Dent Sci, 2021, 16(4): 1055-1065.
8 Razavi BM, Fazly Bazzaz BS. A review and new insights to antimicrobial action of local anesthetics[J]. Eur J Clin Microbiol Infect Dis, 2019, 38(6): 991-1002.
9 Tustin A, Kim SJ, Chomsky A, et al. Antibacterial properties of 2% lidocaine and reduced rate of endophthalmitis after intravitreal injection[J]. Retina, 2014, 34(5): 935-942.
10 Kesici S, Demirci M, Kesici U. Antibacterial effects of lidocaine and adrenaline[J]. Int Wound J, 2019, 16(5): 1190-1194.
11 谭冠中, 刘侃, 陈继营, 等. 利多卡因对细菌培养影响的实验研究[J]. 中国矫形外科杂志, 2019, 27(14): 1302-1305.
Tan GZ, Liu K, Chen JY, et al. Impact of lidocaine on bacterial culture: an experimental study[J].Orthoped J China, 2019, 27(14): 1302-1305.
12 Liu K, Ye LY, Sun W, et al. Does use of lidocaine affect culture of synovial fluid obtained to diagnose periprosthetic joint infection (PJI)? An in vitro study[J]. Med Sci Monit, 2018, 24: 448-452.
13 Stratford AF, Zoutman DE, Davidson JSD. Effect of lidocaine and epinephrine on staphylococcus aureus in a Guinea pig model of surgical wound infection[J]. Plast Reconstr Surg, 2002, 110(5): 1275-1279.
14 Srisatjaluk RL, Klongnoi B, Wongsirichat N. Antimicrobial effect of topical local anesthetic spray on oral microflora[J]. J Dent Anesth Pain Med, 2016, 16(1): 17-24.
15 Aldous WK, Jensen R, Sieck BM. Cocaine and lidocaine with phenylephrine as topical anesthetics: antimicrobial activity against common nasal pathogens[J]. Ear Nose Throat J, 1998, 77(7): 554-557.
16 Chandan SS, Faoagali J, Wainwright CE. Sensitivity of respiratory bacteria to lignocaine[J]. Pathology, 2005, 37(4): 305-307.
17 童寅, 严建平, 郑防军, 等. 利多卡因胶浆对双J管留置术后尿及双J管细菌培养的影响[J]. 中华临床医师杂志(电子版), 2019, 13(4): 277-280.
Tong Y, Yan JP, Zheng FJ, et al. Effect of lidocaine glue on bacterial culture of urine and double-J stent after double-J stent indwelling[J]. Chin J Clinicians (Electro Ed), 2019, 13(4): 277-280.
18 Schorter L, Straubinger RK. Impact of four local anaes-thetics on growth and viability of in vitro cultured Borrelia burgdorferi sensu stricto, Borrelia bava-riensis and Borrelia afzelii [J]. Ticks Tick Borne Dis, 2021, 12(5): 101735.
19 Nai GA, Medina DAL, Martelli CAT, et al. Does washing medical devices before and after use decrease bacterial contamination? An in vitro study[J]. Medicine (Baltimore), 2021, 100(13): e25285.
20 Callahan ZM, Roberts AL, Christopher AN, et al. The effect of commonly used local anesthetic on bacterial growth[J]. J Surg Res, 2022, 274: 16-22.
21 Kesici S, Demirci M, Kesici U. Bacterial inhibition efficiency of prilocaine and bupivacaine[J]. Int Wound J, 2019, 16(5): 1185-1189.
22 Kesici S, Demırci M, Kesici U. Antimicrobial effects of fentanyl and bupivacaine[J]. Braz J Anesthesiol, 2020, 70(4): 357-363.
23 Bátai I, Kerényi M, Falvai J, et al. Bacterial growth in ropivacaine hydrochloride[J]. Anesth Analg, 2002, 94(3): 729-731.
24 Kampe S, Poetter C, Buzello S, et al. Ropivacaine 0.1% with sufentanil 1 microg/mL inhibits in vitro growth of Pseudomonas aeruginosa and does not promote multiplication of Staphylococcus aureus [J]. Anesth Analg, 2003, 97(2): 409-411.
25 Pelz K, Wiedmann-Al-Ahmad M, Bogdan C, et al. Analysis of the antimicrobial activity of local anaesthetics used for dental analgesia[J]. J Med Micro-biol, 2008, 57(Pt 1): 88-94.
26 Kose AA, Karabağgli Y, Kiremitci A, et al. Do local anesthetics have antibacterial effect on Staphylococcus aureus under in vivo conditions? An experimental study[J]. Dermatol Surg, 2010, 36(6): 848-852.
27 Kaewjiaranai T, Srisatjaluk RL, Sakdajeyont W, et al. The efficiency of topical anesthetics as antimicrobial agents: a review of use in dentistry[J]. J Dent Anesth Pain Med, 2018, 18(4): 223-233.
28 Johnson SM, Saint John BE, Dine AP. Local anesthetics as antimicrobial agents: a review[J]. Surg Infect (Larchmt), 2008, 9(2): 205-213.
29 薛昀, 吴新民, 张生锁, 等. 左旋布比卡因和甲磺酸罗哌卡因体外的抑菌作用[J]. 中华麻醉学杂志, 2005, 25(4): 293-294.
Xue Y, Wu XM, Zhang SS, et al. Antibacterial effect of levobupivacaine and ropivacaine mesylate in vitro [J]. Chin J Anesthesiol, 2005, 25(4): 293-294.
30 Schmidt RM, Rosenkranz HS. Antimicrobial activity of local anesthetics: lidocaine and procaine[J]. J Infect Dis, 1970, 121(6): 597-607.
31 Leung YW, Rawal BD. Mechanism of action of te-tracaine hydrochloride against Pseudomonas aeruginosa [J]. J Infect Dis, 1977, 136(5): 679-683.
32 Lygre H, Moe G, Nerdal W, et al. Interaction of articaine hydrochloride with prokaryotic membrane lipids[J]. Acta Odontol Scand, 2009, 67(1): 1-7.
33 Efimova SS, Chulkov EG, Ostroumova OS. Lipid-mediated mode of action of local anesthetics on li-pid pores induced by polyenes, peptides and lipopeptides[J]. Colloids Surf B Biointerfaces, 2018, 166: 1-8.
34 Rodrigues IC, Rodrigues SC, Duarte FV, et al. The role of outer membrane proteins in UPEC antimicrobial resistance: a systematic review[J]. Membranes (Basel), 2022, 12(10): 981.
35 Kenney LJ, Anand GS. EnvZ/OmpR two-component signaling: an archetype system that can function noncanonically[J]. EcoSal Plus, 2020, 9(1):10.1128/ecosalplus.ESP-0001-2019.
36 Silva MT, Sousa JC, Polónia JJ, et al. Effects of local anesthetics on bacterial cells[J]. J Bacteriol, 1979, 137(1): 461-468.
37 Ohsuka S, Ohta M, Masuda K, et al. Lidocaine hydrochloride and acetylsalicylate kill bacteria by disrupting the bacterial membrane potential in different ways[J]. Microbiol Immunol, 1994, 38(6): 429-434.
38 江苏宏锦天药业有限公司. 钠离子通道阻断剂用于治疗抗生素对生物耐药性的新用途: CN101450056-B[P]. 2013-04-24.
Jiangsu Hongjintian Pharmaceutical Co., Ltd. New uses of sodium channel blockers for the treatment of antibiotic resistance to biological agents: CN1014500-56B[P]. 2013-04-24.
39 Pina-Vaz C, Rodrigues AG, Sansonetty F, et al. Antifungal activity of local anesthetics against Candida species[J]. Infect Dis Obstet Gynecol, 2000, 8(3/4): 124-137.
40 Fazly Bazaz BS, Salt WG. Local anaesthetics as antibacterial agents: effects on cellular respiration and the leakage of cytoplasmic constituents[J]. Micro-bios, 1983, 37(149/150): 139-149.
41 El-Zahabi HSA, Nossier ES, Mousa SM, et al. Antibacterial and anticancer profiling of new benzocaine derivatives: design, synthesis, and molecular mechanism of action[J]. Arch Pharm, 2022, 355(4): e2100451.
42 That V, Nguyen S, Poon D, et al. Bioluminescent lux gene biosensors in oral streptococci: determination of complementary antimicrobial activity of minocycline hydrochloride with the anesthetic lidocaine/prilocaine or the antiseptic chlorhexidine[M]//Walchuck RE. Periodontitis: symptoms, treatment and prevention. New York: Nova Science Publi-shers, Inc., 2010: 141-165.
43 Khan HU, Nasir F, Maheen S, et al. Antibacterial and wound-healing activities of statistically optimized nitrofurazone- and lidocaine-loaded silica microspheres by the box-behnken design[J]. Molecules, 2022, 27(8): 2532.
44 朱浩, 张严伟, 刘润, 等. 抗生素佐剂与抗生素联用的抑菌作用研究进展[J]. 生物技术通报, 2022, 38(6): 66-73.
Zhu H, Zhang YW, Liu R, et al. Research progress in antibiotic adjuvant and antibiotics in antibacterial aspects[J]. Biotechnol Bull, 2022, 38(6): 66-73.
45 Kesici U, Demirci M, Kesici S. Antimicrobial effects of local anaesthetics[J]. Int Wound J, 2019, 16(4): 1029-1033.
46 Pirbudak L, Karsligil T, Zer Y, et al. Antibacterial effect of bupivacaine and ropivacaine; effect of adjuvant drugs[J]. Pain Clin, 2005, 17(1): 73-80.
47 Tirupathi SP, Rajasekhar S. Buffered versus unbuffered local anesthesia for inferior alveolar nerve block injections in children: a systematic review[J]. J Dent Anesth Pain Med, 2020, 20(5): 271-279.
48 Aulestia-Viera PV, Braga MM, Borsatti MA. The effect of adjusting the pH of local anaesthetics in dentistry: a systematic review and meta-analysis[J]. Int Endod J, 2018, 51(8): 862-876.
49 Begec Z, Gulhas N, Toprak HI, et al. Comparison of the antibacterial activity of lidocaine 1% versus alkalinized lidocaine in vitro [J]. Curr Ther Res Clin Exp, 2007, 68(4): 242-248.
50 Odden JL, Kowalski RP, Friberg TR. Lidocaine gel interferes with the antibacterial activity of povido-neiodine[J]. Ophthalmic Surg Lasers Imaging Retina, 2021, 52(S1): S13-S16.
51 Xia JL, Lyons RJ, Lin MY, et al. Combination of lidocaine gel and povidone-iodine to decrease acquired infections in procedures performed using topi-cal anesthesia[J]. J Cataract Refract Surg, 2020, 46(7): 1047-1050.
[1] Wu Sijia,Shu Chang,Wang Yang,Wang Yuan,Deng Shuli,Wang Huiming.. Effect and research progress on root canal infection management of regenerative endodontic procedure in immature permanent teeth [J]. Int J Stomatol, 2023, 50(4): 388-394.
[2] Gao Yutian,Su Qin. Research and application of electrolyzed-oxidizing water in the field of root canal treatment [J]. Int J Stomatol, 2023, 50(4): 401-406.
[3] Dai Qingyi,Hao Hao,Hua Chengge,Huang Bo,Yang Zheng. Research progress on oral and maxillofacial sports protective equipment [J]. Int J Stomatol, 2023, 50(3): 366-373.
[4] Zhang Xidan,Sun Jiyu,Fu Xinliang,Gan Xueqi.. Research progress on the development of mesoporous calcium silicate nanoparticles in endodontics and repairing maxillofacial bone defects [J]. Int J Stomatol, 2022, 49(4): 476-482.
[5] Li Ruyi,Luo Feng,Wan Qianbing. Principle and application progress of real-time mandibular motion recording system [J]. Int J Stomatol, 2022, 49(2): 182-189.
[6] Zhu Junjin,Wang Jian.. Advances in the loading methods of silver nanoparticles on the surface of titanium implants [J]. Int J Stomatol, 2021, 48(3): 334-340.
[7] Wang Huan,Liu Yang,Qi Mengchun,Li Jingyi,Liu Mengnan,Sun Hong. Research progress on the preparation of titanium-based implant surface coatings by micro-arc oxidation [J]. Int J Stomatol, 2020, 47(4): 439-444.
[8] Yu Lintong,Song Guangtai. Application of erbium laser in pediatric dentistry [J]. Int J Stomatol, 2020, 47(3): 351-355.
[9] Feng Jin,Wu Hongkun. Research progress on antibacterial dental materials in the treatment of root caries [J]. Int J Stomatol, 2019, 46(4): 475-480.
[10] Yuhao Liu,Quan Yuan,Shiwen Zhang. Recent research progress on the drug-loaded antibacterial coatings of titanium implants based on covalent grafting [J]. Inter J Stomatol, 2019, 46(2): 228-233.
[11] Jin Zhao,Guangyun Lai,Jun Wang. Advances in the status of parental acceptance of treatment under dental general anesthesia for children [J]. Inter J Stomatol, 2018, 45(6): 739-744.
[12] Mengqi Liu,Kuo Gai,Li Jiang. Research progress on oral implant materials with antimicrobial properties [J]. Inter J Stomatol, 2018, 45(5): 516-521.
[13] Xueyang Deng,Lanlan Pan,Ting Hu,Wenhua Li,Xuerong. Xiang. Preparation of graphene oxide coatings on titanium alloy surface [J]. Inter J Stomatol, 2018, 45(5): 539-545.
[14] Liu Dan, Ren Biao, Cheng Lei.. Research development of silver nanoparticle on prevention and treatment of oral infectious disease [J]. Inter J Stomatol, 2018, 45(4): 408-413.
[15] Zeng Yue, Xia Haibin, Wang Min. Research progress on the mechanical and antibacterial properties of nanomaterial-modified denture base [J]. Inter J Stomatol, 2018, 45(4): 455-458.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[2] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[3] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[4] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[5] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[6] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[7] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[8] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[9] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[10] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .