Int J Stomatol

Inter J Stomatol ›› 2014, Vol. 41 ›› Issue (5): 587-592.doi: 10.7518/gjkq.2014.05.021

Previous Articles     Next Articles

Mesenchymal stem cell homing molecules and the homing process

Sun Haipeng, Wang Jinming, Deng Feilong   

  1. Dept. of Implantation, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University; Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China
  • Received:2013-08-20 Revised:2014-01-21 Online:2014-09-01 Published:2014-09-01

RichHTML

5

PDF (PC)

1050

Abstract:

Mesenchymal stem cell(MSC) homing is the process when the endogenous or exogenous MSC migrates to the target tissue in response to the chemotaxis of various factors. MSC transplantation has been explored as a new clinical approach to repair injured tissues. However, the low rate of homing to target tissues and organs limits the therapeutic efficacy of MSC transplantation when used in stem cell therapy. We describe the known mechanisms of MSC homing after reviewing existing studies. A growing corpus of studies have highlighted three important aspects: 1)systemically administered MSC home to sites of injury; 2)the mechanism of MSC homing is very similar to that of leukocytes homing to the inflammatory region; and 3)MSC homing is associated with many ligands and their receptors, including numerous molecules such as chemokines, adhesion molecules, growth factors, and enzymes (i.e., the binding of a ligand to its receptor expressed on MSC has an important function in MSC homing). Understanding the homing of MSC may contribute to the theoretical foundation for the clinical utilization of MSC.

Key words: mesenchymal stem cell, homing, chemotactic factor, adhesion molecule, growth factor

CLC Number: 

  • R 256

TrendMD: 
[1] Li Peitong,Shi Binmian,Xu Chunmei,Xie Xudong,Wang Jun.. Distribution and role of Gli1+ mesenchymal stem cells in teeth and periodontal tissues [J]. Int J Stomatol, 2023, 50(1): 37-42.
[2] Zhou Can,Zeng Qian,Wei Xi.. Prospects for the application of concentrated growth factor in vital pulp therapy [J]. Int J Stomatol, 2022, 49(6): 684-689.
[3] Xiong Menglin,Wu Long,Ma Li,Zhao Jin. Role of transforming growth factor-β2 in promoting the proliferation and differentiation of dental pulp stem cells [J]. Int J Stomatol, 2021, 48(6): 635-639.
[4] Shi Peilei,Yu Chenhao,Xie Xudong,Wu Yafei,Wang Jun. Research progress on the application of dental-derived mesenchymal stem cells in periodontal defect repair [J]. Int J Stomatol, 2021, 48(6): 690-695.
[5] Liu Juan,Chen Bin,Yan Fuhua. Effects of platelet-rich plasma and concentrated growth factor on the proliferation and osteogenic differentiation of human periodontal cells [J]. Int J Stomatol, 2021, 48(5): 520-527.
[6] Gong Jinglei,Huang Yanmei,Wang Jun. Research progress on multiphasic scaffold in periodontal regeneration [J]. Int J Stomatol, 2021, 48(5): 563-569.
[7] Deng Shiyong,Gong Ping,Tan Zhen. Effects of brain and muscle aryl hydrocarbon receptor nuclear translocator-like protein 1 gene on the regulation of oral and systemic bone metabolism [J]. Int J Stomatol, 2021, 48(2): 198-204.
[8] Chen Ye, Zhou Feng, Wu Qionghui, Che Huiling, Li Jiaxuan, Shen Jiaqi, Luo En. Effect of adiponectin on bone marrow mesenchymal stem cells and its regulatory mechanisms [J]. Int J Stomatol, 2021, 48(1): 58-63.
[9] Lü Hui,Wang Hua,Sun Wen. T helper cell 17 and periodontitis related osteoimmunology [J]. Int J Stomatol, 2020, 47(6): 661-668.
[10] Yang Yeqing,Chen Ming,Wu Buling. Research progress on circular RNA in the osteogenic differentiation of mesenchymal stem cells [J]. Int J Stomatol, 2020, 47(3): 257-262.
[11] Liu Junqi,Chen Yiyin,Yang Wenbin. Research progress on N6-methyladenosine for regulating the osteogenic differentiation of bone marrow mesenchymal stem cells [J]. Int J Stomatol, 2020, 47(3): 263-269.
[12] Zhu Mingjing,Zhang Qingbin. Comparative review of growth factors inducing 3D in vitro cartilage formation of mesenchymal stem cells [J]. Int J Stomatol, 2020, 47(3): 270-277.
[13] Wu Xiaonan,Ma Ning,Hou Jianxia. Research progress of exosomes derived from different stem cells in periodontal regeneration [J]. Int J Stomatol, 2020, 47(2): 146-151.
[14] Wei Zhongwu,Huang Xieshan,Chen Zhuogeng. Application and research progress on concentrated growth factor in oral clinic [J]. Int J Stomatol, 2020, 47(2): 235-243.
[15] Ya Yang,Peng Chen,Hongwei Dai,Lin Zhang. Change in expression of transformation growth factor-β/Smad signalling pathway-related proteins in epithelial rests of Malassez during orthodontic tooth movement in rats [J]. Int J Stomatol, 2019, 46(3): 270-276.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[2] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[3] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[4] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[5] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[6] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[7] . [J]. Foreign Med Sci: Stomatol, 2005, 32(06): 458 -460 .
[8] . [J]. Foreign Med Sci: Stomatol, 2005, 32(06): 452 -454 .
[9] . [J]. Inter J Stomatol, 2008, 35(S1): .
[10] . [J]. Inter J Stomatol, 2008, 35(S1): .