Int J Stomatol

Inter J Stomatol ›› 2012, Vol. 39 ›› Issue (3): 360-364.doi: 10.3969/j.issn.1673-5749.2012.03.022

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Insulin -like growth factor - Ⅰ and its regulation on the development of mandibular condylar cartilage

Jiang Liting, Gao Yiming.   

  1. Dept. of Stomatology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China
  • Received:2010-12-13 Revised:2011-12-12 Online:2012-05-01 Published:2012-05-01

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Abstract:

The postnatal condylar cartilage lives in complex mechanical micro-circumstances, and its growth and modification depends on proliferation and differentiation of condylar chondrocytes. Insulin-like growth factor（IGF）- Ⅰ is one of the important growth factors during growth and development in the condylar cartilage. At the cellular level, IGF-Ⅰexerts its biological actions through the binding and activation of IGF-Ⅰ , and its bioefficacy is modulated by IGF binding proteins（IGFBP）. IGF-Ⅰ induces variety cellular responses, including cell proliferation, differentiation, and aopotosis, promoting matrix synthesis and taking part in intercellular signal mechanotransduction. The article reviews IGF - Ⅰ and its receptor, IGFBP and its role and mechanism on the development of postnatal mandibular condylar cartilage.

Key words: insulin-like growth factor, condylar cartilage, development, role and mechanism


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