Int J Stomatol

Inter J Stomatol ›› 2012, Vol. 39 ›› Issue (1): 97-100.doi: 10.3969/j.issn.1673-5749.2012.01.027

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Role of syndecan -4 and a disintegrin and metalloproteinase with thrombospondin motif -1 in wound healing

Qin Yanyan, Wang Dan, Lin Chongtao.   

  1. Dept. of Periodontics, Hospital of Stomatology, Jilin University, Changchun 130021, China
  • Received:2010-08-28 Revised:2011-08-25 Online:2012-01-01 Published:2012-01-01

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Abstract:

Syndecan-4, a newly discovered peptide, which distributes in many tissues, mediates a variety of physiological responses. A disintegrin and metalloproteinase with thrombospondin motif-1（ADAMTS-1）, a novel metalloproteinase, is widely expressed in mammals and invertebrates cells. ADAMTS-1 plays a key role in physiology and pathology process such as maintaining coagulation system steady, organ formation, inflammation, reproduction. Many studies have shown that syndecan-4 and ADAMTS-1 are involved in the wound healing, and found that ADAMTS-1 is uniquely cleave the transmembrane proteoglycan syndecan-4. This review is about the structure, properties of the syndecan-4 and ADAMTS-1, and the role of them in wound healing. The purpose is to provide a theoretical basis for periodontal regeneration.

Key words: a disintegrin and metalloproteinase with thrombospondin motif, syndecan, wound healing, periodontal tissue


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