Int J Stomatol

Inter J Stomatol ›› 2010, Vol. 37 ›› Issue (5): 548-551.doi: 10.3969/j.issn.1673-5749.2010.05.015

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Wnt/β-catenin signaling pathway and bone remodeling

FU Bin1, TANG Guo -hua2.   

  1. 1. Key Laboratory of Shanghai Stomatology; 2. Dept. of Orthodontics, The Ninth People′s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China
  • Online:2010-09-20 Published:2010-09-20

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Abstract:

Wnt signaling pathway is one of the most important regulatory systems that plays a key role in modulating the differentiation, proliferation and programmed cell death of osteoblast, osteoclast and chondrocyte. The research progress of the role of canonical Wnt/β-catenin pathway in regulating bone remodeling is summarized in this review, its function on osteoclastogenesis and programmed cell death of osteoblast is discussed in details.

Key words: Wnt signaling pathway, osteoblast, programmed cell death, osteoclast, bone remodeling


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