Int J Stomatol

Inter J Stomatol ›› 2010, Vol. 37 ›› Issue (4): 386-391.doi: 10.3969/j.issn.1673-5749.2010.04.004

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Relationship between human herpes virus -5 to 8 and oral lichen planus 

 GU Yang1, LI Jing -quan2, LI Ming - han1, GONG Liang -wen1, XU Hao2, ZHANG Hong1, LI Wen -yan1, CHEN Zheng -han2.   

  1. 1. Dept. of Oral Medicine, College of Stomatology, Dalian Medical University, Dalian 116027, China; 2. TaKaRa Biotechnology Dalian Company Limited, Dalian 116600, China
  • Online:2010-07-20 Published:2010-07-20

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Abstract:

Objective The aim of this study is to survey the potential relationship between oral lichen planus （OLP） and human herpesvirus（HHV）-5 to 8. Methods Seriously selected 36 OLP patients and 43 healthy controls, and meanwhile we collected their 6 kinds of samples including white blood cell（WBC）, serum, saliva, exfoliated cell（un-lesion and lesion sections）, and biopsy samples. The real-time polymerase chain reaction technology was employed to explore the DNA copies of HHV-5 to 8. Results The HHV-5 positive rates in OLP samples are, WBC 50.00%（8/16）, saliva 25.00%（4/16）, biopsies 80.00%（4/5）, exfoliated cells from un -lesion sections 18.75%（3/16）and lesion sections 50.00%（8/16） respectively. The counterpart in healthy controls are, saliva 20.00%（2/10） and WBC 30.00%（3/10）, respectively. The HHV-6 positive rates in OLP samples are WBC 18.75%（3/16）, biopsies 40.00%（2/5） and exfoliated cells from un-lesion sections 12.50%（2/16） respectively. The counterpart in healthy controls is only in saliva 10.00%（1/10）. The only HHV-7 positive rate is in OLP saliva 30.00%（6/20）. The counterpart in healthy controls is also in saliva 15.00%（3/20）. However, the copy of HHV-8 could not be explored in all samples. Conclusion The Chi-square test（掊2=6.829 0, P<0.05） and the value of Pearson contingency coefficient（0.208 0） showed that HHV-5 was significantly closely related with patients with OLP, but HHV-6 and 7 were not. The number of HHV-5 DNA copy has a significant different between WBC and exfoliated cells from un-lesion sections in OLP group（P=0.001）

Key words: oral lichen planus, human herpesvirus, real-time polymerase chain reaction


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