孕妇口腔微生物影响新生儿口腔及全身健康的研究进展

doi:10.7518/gjkq.2025074

摘要/Abstract

摘要：

孕妇口腔健康对妊娠结局（如早产、低出生体重儿、先兆子痫、死胎等）的影响早已受到学者们的广泛关注。随着胎盘、羊水等母体结构中检出口腔微生物，孕妇口腔微生物对胎儿子宫内定植、塑造胎儿免疫系统，以及对新生儿后续口腔健康的影响及可能机制成为了新的研究热点。本文综述了近年来孕妇口腔微生物对胎儿健康及新生儿口腔微生物群的影响：孕妇口腔微生物群可能通过生命早期口腔微生物的定植及演替影响口腔健康，并可能调节胎儿发育，对全身健康也会产生深远影响。

关键词: 新生儿, 孕妇, 口腔微生物, 微生物子宫内定植, 生命早期微生物

Abstract:

The influence of maternal oral health on pregnancy outcomes (such as preterm low birth weight, preeclampsia, and stillbirth) has been widely concerned by scholars. With the detection of oral microorganisms in the placenta, amnio-tic fluid, and other maternal structures, the influence and possible mechanism of oral microorganisms in pregnant women on the colonization of the fetus in the womb; the shaping of the fetal immune system; and the subsequent oral health of the newborn have become a new research hotspot. In this study, the effects of maternal oral microbiota on fetal health neonatal oral microbiota were reviewed. The maternal oral microbiota may influence oral health through the colonization and succession of oral microbiota during early life and may regulate fetal development, which has a profound impact on systemic health.

Key words: newborn, pregnant women, oral microorganism, microbial colonization in utero, early life microorganis

中图分类号:

R780.2

邓含知,赵蕾. 孕妇口腔微生物影响新生儿口腔及全身健康的研究进展[J]. 国际口腔医学杂志, 2025, 52(4): 552-558.

Hanzhi Deng,Lei Zhao. Research progress on the effects of maternal oral microorganisms on neonatal oral and systemic health[J]. Int J Stomatol, 2025, 52(4): 552-558.

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