低能量激光促进正畸牙移动有效性研究的系统评价与Meta分析

doi:10.7518/gjkq.2022042

摘要/Abstract

摘要：

目的运用系统评价和Meta分析的方法探讨低能量激光促进正畸牙移动的有效性。方法通过计算机检索PubMed、Embase、Cochrane library及中国知网（CNKI）、万方、维普数据库后对文献进行筛选。按正畸牙移动的时间将结局指标分为4组进行讨论,分别为1周、1、2和3个月,将不同时间段的尖牙移动量作为连续性随机变量进行数据处理。使用 Review Manager 5.3软件对结局指标进行传统Meta分析,再根据低能量激光的能量密度将所纳入的研究分为3组,使用Stata 15.0软件进行网络Meta分析（NMA ）。结果该系统评价已在Prospero网站进行注册,注册号为CRD42020175850。最后,24篇进入系统评价范围,23篇进入Meta分析范围。结论在 1周、1、2和3个月时,低能量激光治疗均可促进正畸牙移动。在1、2和3个月时,能量密度0~10 J·cm^-2的效果均优于10~25 J·cm^-2。

关键词: 正畸, 牙齿移动, 低能量激光, 系统评价

Abstract:

Objective This study aims to investigate the effectiveness of low-level laser in promoting orthodontic tooth movement by systematic review and meta-analysis. Methods Studies were included after searching PubMed, Embase, Cochrane library, China national knowledge infrastructure (CNKI), Wanfang, and VIP databases. Outcome indicators were divided into four groups according to the time of orthodontic tooth movement, namely, 1 week, 1 month, 2 months, and 3 months. Data processing was performed on the volume of canine movement in different time periods as a continuous random variable. Traditional meta-analysis was performed using Review Manager 5.3, and the included studies were divided into three groups according to energy density parameters. Stata 15.0 software was used for network meta-analysis (NMA). Results The systematic review has been registered on Prospero’s website with registration number CRD42020175850. Twenty-four studies were finally included in the systematic evaluation, and 23 literatures were included in the meta-analysis. Conclusion Low-level laser therapy can promote orthodontic tooth movement at 1 week, 1 month, 2 months, and 3 months. The energy density of 0-10 J·cm^-2 was better than that of 10-25 J·cm^-2 at 1, 2, and 3 months.

Key words: orthodontics, tooth movement, low-level laser, systematic review

中图分类号:

R783.5

郭子源,常笑,韩开放,张锡忠. 低能量激光促进正畸牙移动有效性研究的系统评价与Meta分析[J]. 国际口腔医学杂志, 2022, 49(2): 163-172.

Guo Ziyuan,Chang Xiao,Han Kaifang,Zhang Xizhong. Low-level laser therapy for acceleration of fixed orthodontic tooth movement: a systematic review and meta-analysis[J]. Int J Stomatol, 2022, 49(2): 163-172.

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参考文献	纳入数（干预/对照）	能量密度	正畸力/N	结局指标
[12]	10/10	20 mw·cm^-2	Not given	尖牙移动量
[13]	10/10	0.5 w·cm^-2	1.5	尖牙移动量
[14]	12/12	Not given	1.5	尖牙移动率
[15]	11/11	5 J·cm^-2	1.5	尖牙移动量
[16]	12/12	5 J·cm^-2	1.5	尖牙移动量
[17]	20/20	Not given	1.5	尖牙移动量
[18]	20/20	20 mw·cm^-2	1.5	尖牙移动量
[19]	60/30	Not given	Not given	尖牙移动量
[20]	20/20	2.5 J·cm^-2	1.5	尖牙移动量
[21]	20/20	2.5 J·cm^-2	1.5	尖牙移动量
[22]	20/20	5 J·cm^-2	1.5	尖牙移动量
[23]	20/20	21.4 J·cm^-2	1.5	尖牙移动量
[24]	16/16	15.92 J·cm^-2	1.5	尖牙移动量
[25]	10/10	4.2 J·cm^-2	1.5	尖牙移动量
[26]	12/12	25 J·cm^-2	1.5	尖牙移动量
[27]	22/22	1.97 w·cm^-2	1.5	尖牙移动量
[28]	11/11	10 J·cm^-2	1.5	尖牙移动量
[29]	15/15	5 J·cm^-2	1.5	尖牙移动量
[30]	22/22	7.5 J·cm^-2	1.5	尖牙移动量
[31]	13/13	5 J·cm^-2	1.5	尖牙移动量
[32]	10/10	8 J·cm^-2	1.5	尖牙移动量
[33]	17/17	5 J·cm^-2	1.25	尖牙移动量
[34]	36/36	2.5 J·cm^-2	1.37	尖牙移动量
[35]	30/30	Not given	1.5	尖牙移动量
[23]	20/20	21.4 J·cm^-2	1.5	尖牙移动量
[24]	16/16	15.92 J·cm^-2	1.5	尖牙移动量
[25]	10/10	4.2 J·cm^-2	1.5	尖牙移动量
[26]	12/12	25 J·cm^-2	1.5	尖牙移动量
[27]	22/22	1.97 w·cm^-2	1.5	尖牙移动量
[28]	11/11	10 J·cm^-2	1.5	尖牙移动量
[29]	15/15	5 J·cm^-2	1.5	尖牙移动量
[30]	22/22	7.5 J·cm^-2	1.5	尖牙移动量
[31]	13/13	5 J·cm^-2	1.5	尖牙移动量
[32]	10/10	8 J·cm^-2	1.5	尖牙移动量
[33]	17/17	5 J·cm^-2	1.25	尖牙移动量
[34]	36/36	2.5 J·cm^-2	1.37	尖牙移动量
[35]	30/30	Not given	1.5	尖牙移动量