糖尿病与味觉损害的关系

doi:10.7518/gjkq.2018.03.021

摘要/Abstract

摘要： 味觉是一种相当复杂和重要的特殊感觉,在维持动物内环境稳定中扮演着重要的角色。糖尿病影响着味觉,味觉损害是糖尿病的并发症之一。糖尿病患者味觉障碍的发生大大降低了其生活质量。近年来糖尿病的患病率呈上升趋势,因此研究糖尿病味觉损害发生机制至关重要。本文就糖尿病味觉损害发生机制的研究进展作一综述。

关键词: 味觉, 味觉损害, 糖尿病, 发生机制

Abstract: Taste is a very complex and important special feeling, and plays an important role in maintaining a stable environment within the animal. While diabetes affects the taste, taste impairment is one of the complications of diabetes. The occurrence of the sense of taste disorder in patients with diabetes significantly reduced their quality of life. In recent years, the prevalence of diabetes has become a rising trend. Therefore, it is very important to study the mechanism of the occurrence of diabetic taste damage . This paper reviews the research progress of diabetic taste damage.

Key words: taste, taste damage, diabetes, mechanism

中图分类号:

刘彩云, 陶怡然. 糖尿病与味觉损害的关系[J]. 国际口腔医学杂志, 2018, 45(3): 358-361.

Liu Caiyun, Tao Yiran. Correlation between taste injury and diabetes[J]. Inter J Stomatol, 2018, 45(3): 358-361.

参考文献

[1] 李燕, 刘清君, 徐莹, 等. 味觉传导机理及味觉芯片技术研究进展[J]. 科学通报, 2005, 50(14):1425-1433.
Li Y, Liu QJ, Xu Y, et al.Research progress on the me-chanism of taste transduction and the technology of taste chip[J]. Chin Sci Bullet, 2005, 50(14):1425-1433.
[2] Pai MH, Ko TL, Chou HC.Effects of streptozotocin-induced diabetes on taste buds in rat vallate papillae[J]. Acta Histochem, 2007, 109(3):200-207.
[3] 段晖, 秦玉梅, 熊艺姣, 等. 链脲佐菌素诱导糖尿病小鼠轮廓状乳头中味蕾特征变化[J]. 食品与生物技术学报, 2013, 32(6):628-632.
Duan H, Qin YM, Xiong YJ, et al.Character changes of taste buds in mice circumvallate papillae of strep-tozotocin-induced diabetes[J]. J Food Sci Biotechnol, 2013, 32(6):628-632.
[4] Batbayar B, Zelles T, Vér A, et al.Plasticity of the different neuropeptide-containing nerve fibres in the tongue of the diabetic rat[J]. J Peripher Nerv Syst, 2004, 9(4):215-223.
[5] 刘聪. 味觉受体信号传导家族系列基因—Taslr2,Taslr3及TRPM5基因多型性与2型糖尿病的关系[D]. 沈阳: 中国医科大学, 2004.
Liu C.Relationship between Taslr2, Taslr3 and TRPM5 gene polymorphisms and type 2 diabetes mellitus[D]. Shenyang: Chinese Medical University, 2004.
[6] Young RL, Chia B, Isaacs NJ, et al.Disordered con-trol of intestinal sweet taste receptor expression and glucose absorption in type 2 diabetes[J]. Diabetes, 2013, 62(10):3532-3541.
[7] 周立红. 味蛋白、甜味受体与2型糖尿病关系的研究[D]. 哈尔滨: 哈尔滨医科大学, 2008.
Zhou LH.The study in taste impairment of type 2 diabetes mellitus[D]. Harbin: Harbin Medical University, 2008.
[8] Moore PA, Guggenheimer J, Etzel KR, et al.Type 1 diabetes mellitus, xerostomia, and salivary flow rates[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2001, 92(3):281-291.
[9] Carda C, Mosquera-Lloreda N, Salom L, et al.Struc-tural and functional salivary disorders in type 2 dia-betic patients[J]. Med Oral Patol Oral Cir Bucal, 2006, 11(4):E309-E314.
[10] 冯晓红, 刘晓民, 周立红, 等. 糖尿病大鼠味腺超微结构的研究[J]. 解剖学报, 2008, 39(2):252-254.
Feng XH, Liu XM, Zhou LH, et al.Ultrastructural studies on von Ebner’ gland of diabetes rats[J]. Acta Anat Sin, 2008, 39(2):252-254.
[11] Brown D, Garcia-Segura LM, Orci L.Carbonic anhydrase is associated with taste buds in rat tongue[J]. Brain Res, 1984, 324(2):346-348.
[12] Goto T, Shirakawa H, Furukawa Y, et al.Decreased expression of carbonic anhydrase isozyme Ⅱ, rather than of isozyme Ⅵ, in submandibular glands in long-term zinc-deficient rats[J]. Br J Nutr, 2008, 99(2): 248-253.
[13] Komai M, Goto T, Suzuki H, et al.Zinc deficiency and taste dysfunction; contribution of carbonic an-hydrase, a zinc-metalloenzyme, to normal taste se-nsation[J]. Biofactors, 2000, 12(1/2/3/4):65-70.
[14] Goto T, Komai M, Bryant BP, et al.Reduction in carbonic anhydrase activity in the tongue epithelium and submandibular gland in zinc-deficient rats[J]. Int J Vitam Nutr Res, 2000, 70(3):110-118.
[15] 任丽红. 锌与糖尿病味觉减退和糖尿病并发症关系的研究[D]. 哈尔滨: 哈尔滨医科大学, 2008.
Ren LH.A study of the relationship between zinc and diabetic hypogeusia and diabetic complications [D]. Harbin: Harbin Medical University, 2008.
[16] Jakobsen J, Brimijoin S, Skau K, et al.Retrograde axonal transport of transmitter enzymes, fucose-labeled protein, and nerve growth factor in streptozo-tocin-diabetic rats[J]. Diabetes, 1981, 30(10):797-803.
[17] Alzoubi KH, Khabour OF, Alhaidar IA, et al.Dia-betes impairs synaptic plasticity in the superior cer-vical ganglion: possible role for BDNF and oxidative stress[J]. J Mol Neurosci, 2013, 51(3):763-770.
[18] Mistretta CM, Goosens KA, Farinas I, et al.Altera-tions in size, number, and morphology of gustatory papillae and taste buds in BDNF null mutant mice demonstrate neural dependence of developing taste organs[J]. J Comp Neurol, 1999, 409(1):13-24.
[19] 孟杨, 边专, 汪说之, 等. 人味蕾的味孔、味凹的超微结构观察[J]. 中华口腔医学杂志, 2006, 41(12): 762-763.
Meng Y, Bian Z, Wang SZ, et al.Ultrastructure of the taste pores and taste pits of human taste buds[J]. Chin J Stomatol, 2006, 41(12):762-763.

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