国际口腔医学杂志 ›› 2016, Vol. 43 ›› Issue (3): 357-360.doi: 10.7518/gjkq.2016.03.023
宁毅1,郑晓旭2,孙睿3
Ning Yi1, Zheng Xiaoxu2, Sun Rui3
摘要: 转换蛋白(TRA)2为前体mRNA剪接蛋白,是一族富含丝氨酸-精氨酸重复剪接因子(SR)家族的相关蛋白,包括TRA2α和TRA2β两个亚族。它们在结构上与SR蛋白有着一定的相似性,在功能上与SR蛋白有着明显的差异,即TRA2蛋白不为组成性剪接所必需,但在选择性前体mRNA剪接中决定剪接位点方面却起着重要的作用。在哺乳动物中,TRA2蛋白家族在生理和病理过程中发挥着诸多关键性作用,且在疾病的发生发展过程中错误地调控剪接过程产生异常的RNA可引起分子病或者导致原来的疾病更加严重。迄今为止,人们还不清楚TRA2蛋白与疾病间的关系,所以对其引起疾病的治疗研究还处在初级阶段。
中图分类号:
[1] Nayler O, Cap C, Stamm S. Human transformer-2-beta gene (SFRS10): complete nucleotide sequence, chromosomal localization, and generation of a tissue specific isoform[J]. Genomics, 1998, 53(2):191-202. [2] Beil B, Screaton G, Stamm S. Molecular cloning of htra2-beta-1 and htra2-beta-2, two human homologs of tra-2 generated by alternative splicing[J]. DNA Cell Biol, 1997, 16(6):679-690. [3] Takeo K, Kawai T, Nishida K, et al. Oxidative stressinduced alternative splicing of transformer 2beta (SFRS10) and CD44 pre-mRNAs in gastric epithelial cells[J]. Am J Physiol Cell Physiol, 2009, 297(2): C330-C338. [4] Elliott DJ, Best A, Dalgliesh C, et al. How does Tra2β protein regulate tissue-specific RNA splicing [J]. Biochem Soc Trans, 2012, 40(4):784-788. [5] Tacke R, Manley JL. Functions of SR and Tra2 proteins in pre-mRNA splicing regulation[J]. Proc Soc Exp Biol Med, 1999, 220(2):59-63. [6] Tacke R, Tohyama M, Ogawa S, et al. Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing[J]. Cell, 1998, 93(1):139-148. [7] Tsuda K, Someya T, Kuwasako K, et al. Structural basis for the dual RNA-recognition modes of human Tra2-β RRM[J]. Nucleic Acids Res, 2011, 39(4):1538-1553. [8] 刘培文, 陈宇婷, 顾金保, 等. 埃及伊蚊性别决定基因Transformer 2的鉴定与表达分析[J]. 南方医科大学学报, 2013, 33(11):1583-1589. Liu PW, Chen YT, Gu JB, et al. Isolation and expression profiling of transformer 2 gene in Aedes aegypti[J]. J South Med Univ, 2013, 33(11):1583-1589. [9] Daoud R, Mies G, Smialowska A, et al. Ischemia induces a translocation of the splicing factor tra2-beta 1 and changes alternative splicing patterns in the brain[J]. J Neurosci, 2002, 22(14):5889-5899. [10] Stoilov P, Daoud R, Nayler O, et al. Human tra2-beta1 autoregulates its protein concentration by influencing alternative splicing of its pre-mRNA[J]. Hum Mol Genet, 2004, 13(5):509-524. [11] Roberts JM, Ennajdaoui H, Edmondson C, et al. Splicing factor TRA2B is required for neural progenitor survival[J]. J Comp Neurol, 2014, 522(2):372-392. [12] Tsukamoto Y, Matsuo N, Ozawa K, et al. Expression Expression of a novel RNA-splicing factor, RA301/Tra2-beta, in vascular lesions and its role in smooth muscle cell proliferation[J]. Am J Pathol, 2001, 158(5):1685-1694. [13] Kiryu-Seo S, Matsuo N, Wanaka A, et al. A sequence-specific splicing activator, tra2beta, is upregulated in response to nerve injury[J]. Brain Res Mol Brain Res, 1998, 62(2):220-223. [14] Watermann DO, Tang Y, Zur Hausen A, et al. Splicing factor Tra2-beta1 is specifically induced in breast cancer and regulates alternative splicing of the CD44 gene[J]. Cancer Res, 2006, 66(9):4774-4780. [15] Kajita K, Kuwano Y, Kitamura N, et al. Ets1 and heat shock factor 1 regulate transcription of the Transformer 2β gene in human colon cancer cells[J]. J Gastroenterol, 2013, 48(11):1222-1233. [16] Best A, Dagliesh C, Ehrmann I, et al. Expression of Tra2 β in cancer cells as a potential contributory factor to neoplasia and Metastasis[J]. Int J Cell Biol, 2013, 2013:843781. [17] Best A, Dagliesh C, Ehrmann I, et al. Expression of tra2β in cancer cells as a potential contributory factor to neoplasia and metastasis[J]. Int J Cell Biol, 2013, 2013:1-9. [18] Anderson ES, Lin CH, Xiao X, et al. The cardiotonic steroid digitoxin regulates alternative splicing through depletion of the splicing factors SRSF3 and TRA2B[J]. RNA, 2012, 18(5):1041-1049. [19] Dreumont N, Bourgeois CF, Lejeune F, et al. Human RBMY regulates germline-specific splicing events by modulating the function of the serine/argininerich proteins 9G8 and Tra2-β[J]. J Cell Sci, 2010, 123 (Pt 1):40-50. [20] Chen X, Li J, Wu K, et al. Tra2alpha promotes RA induced neural differentiation of P19 cells[J]. Neurochem Res, 2005, 30(2):271-275. [21] Park E, Han J, Son GH, et al. Cooperative actions of Tra2alpha with 9G8 and SRp30c in the RNA splicing of the gonadotropin-releasing hormone gene transcript[J]. J Biol Chem, 2006, 281(1):401-409. (本文采编 王晴) |
[1] | 陈冬茹 吴莉萍. 低氧诱导因子-1α和反义低氧诱导因子-1α的研究进展[J]. 国际口腔医学杂志, 2016, 43(5): 589-593. |
[2] | 侯丽雯 焦婷 谢明. 血管内皮生长因子与牙发生发育的关系[J]. 国际口腔医学杂志, 2016, 43(5): 605-609. |
[3] | 侯玉帛1 刘歆婵2 于海燕1 崔磊华3 于维先4. 牙龈蛋白及其对破骨和成骨细胞功能的影响[J]. 国际口腔医学杂志, 2016, 43(5): 609-613. |
[4] | 赵兴福,江山,黄晓晶,闫福华. 变异链球菌临床株表面相关蛋白表达差异的初步分析[J]. 国际口腔医学杂志, 2016, 43(3): 273-277. |
[5] | 陈甜,白丁. 骨硬化蛋白对牙骨质形成的影响及其机制[J]. 国际口腔医学杂志, 2016, 43(3): 333-337. |
[6] | 廖军,徐普. 富血小板血纤蛋白在牙槽嵴位点保存中的应用[J]. 国际口腔医学杂志, 2016, 43(2): 216-219. |
[7] | 徐基亮,夏荣. 精氨酸-甘氨酸-天冬氨酸修饰钛材料表面的研究进展[J]. 国际口腔医学杂志, 2016, 43(2): 190-194. |
[8] | 徐巾诏1 蓝菁2 汲平2. 卷曲蛋白在无翅型小鼠乳房肿瘤病毒整合位点家族-卷曲蛋白信号转导通路中的作用[J]. 国际口腔医学杂志, 2016, 43(1): 85-. |
[9] | 杜琳玲 冯娟. 人中性粒细胞肽-1~3及其与患龋风险的关系[J]. 国际口腔医学杂志, 2015, 42(6): 699-702. |
[10] | 於丽明1 沈庆平1 陈锦坤2. 脂联蛋白及其与成骨和骨代谢的关系[J]. 国际口腔医学杂志, 2015, 42(6): 681-684. |
[11] | 刘梦余 叶玲 汪成林. 白细胞介素-17及其在口腔疾病中的作用[J]. 国际口腔医学杂志, 2015, 42(6): 728-732. |
[12] | 班华杰1 王代友2. 细胞外信号调节激酶信号转导通路在牙发生和再生中的作用[J]. 国际口腔医学杂志, 2015, 42(6): 694-698. |
[13] | 吴冷 王骏 赵蕾 吴亚菲. 核苷酸结合寡聚化结构域样受体热蛋白结构域亚家族成员3炎症小体的活化调节与牙周疾病的关系[J]. 国际口腔医学杂志, 2015, 42(6): 710-714. |
[14] | 姜慧 黄萍. β-防御素-3及其与牙周炎和糖尿病的关系[J]. 国际口腔医学杂志, 2015, 42(3): 339-343. |
[15] | 饶利佳 李启梦 徐琼. 1011易位甲基胞嘧啶双加氧酶-1的结构和去甲基化作用及生物学功能[J]. 国际口腔医学杂志, 2015, 42(3): 323-327. |
|