国际口腔医学杂志

国际口腔医学杂志 ›› 2018, Vol. 45 ›› Issue (5): 509-515.doi: 10.7518/gjkq.2018.05.003

• 中青年专家笔谈 • 上一篇    下一篇

降钙素基因相关肽对种植体周围神经、血管再生及骨结合的作用

向琳,陈晖璐,袁影,张勤,辛娜,宫苹()   

  1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院种植科 成都 610041
  • 收稿日期:2018-02-12 修回日期:2018-06-09 出版日期:2018-09-01 发布日期:2018-09-20
  • 通讯作者: 宫苹
  • 作者简介:·专家简介·
    向琳,讲师,博士,Email：dentistxiang@126.com
    向琳,四川大学华西口腔医学院、美国哈佛大学牙学院联合培养博士,现任四川大学华西口腔医学院讲师,主要研究方向为牙种植体骨结合,已在国际国内发表多篇学术论文,参编多本口腔种植专著。主持多项国家自然科学基金、中央高校专项基金、中国博士后科学基金、四川省科技计划等项目。曾多次赴国内外进行学术交流及培训,现为中华口腔医学会、中华口腔医学会口腔种植专业委员会、国际牙科研究协会会员。
  • 基金资助:
    国家自然科学基金(81701007);国家自然科学基金(2018RZ0087);中央高校基本科研业务费专项资金(2017SCU12056);中央高校基本科研业务费专项资金(2018SCUH0006);中国博士后科学基金资助项目(2018M631091);四川大学华西口腔医院青年科学研究基金项目(2016-11)

Research progress on calcitonin gene-related peptide on peripheral nerve, vascular regeneration and osseointegra-tion around implants

Lin Xiang,Huilu Chen,Ying Yuan,Qin Zhang,Na Xin,Ping. Gong()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2018-02-12 Revised:2018-06-09 Online:2018-09-01 Published:2018-09-20
  • Contact: Ping. Gong
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81701007);Sichuan Science and Technology Program(2018RZ0087);the Fundamental Research Funds for the Central Universities(2017SCU12056);the Fundamental Research Funds for the Central Universities(2018SCUH0006);Project funded by China Postdoctoral Science Foundation(2018M631091);Youth Science Foundation of West China Hospital of Stomatology of Sichuan University(2016-11)

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摘要：

降钙素基因相关肽（CGRP）系一类主要由感觉神经释放的生物活性神经肽类物质。近年来,CGRP在种植体骨结合过程中的调节作用已受到该领域的广泛关注：CGRP阳性神经纤维存在于种植体周的骨组织中;CGRP与种植体周微血管的分布相关联,提示CGRP与局部以微循环为主的血管再生可能存在某种联系;此外,CGRP能够促进周围神经再生,CGRP阳性神经纤维在种植体周呈规律性分布变化。本文就CGRP对牙种植体骨结合和以微循环改建为主的血管再生以及周围神经再生的研究进展作一综述。

关键词: 牙种植, 降钙素基因相关肽, 骨结合, 微循环, 周围神经

Abstract:

Calcitonin gene-related peptide (CGRP) is a class of biologically active neuropeptide substances mainly released by the sensory nerve. In recent years, the role of CGRP in osseointeration around implants has received wide attention: CGRP positive nerve fibers are present in the bone tissue around the implant; CGRP is associated with the distribution of the capillary vessels around the implant, which suggests that CGRP may have a link with local revascularization on the base of microcirculation. In addition, CGRP could promote the peripheral nerve regeneration, and CGRP positive nerve fibers show regular changes in implant circumference. This paper will make a review of the research progress of CGRP on peripheral nerve, vascular regeneration and osseointegration around implants.

Key words: dental implant, calcitonin gene-related peptide, osseointegration, microcirculation, peripheral nerve

中图分类号: 

  • R783.6
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