国际口腔医学杂志 ›› 2021, Vol. 48 ›› Issue (4): 439-443.doi: 10.7518/gjkq.2021078

• 综述 • 上一篇    下一篇

先天性梅毒牙的研究现状

孟抒怀(),罗锋,裴锡波,万乾炳()   

  1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院修复Ⅰ科 成都 610041
  • 收稿日期:2021-01-05 修回日期:2021-04-02 出版日期:2021-07-01 发布日期:2021-06-30
  • 通讯作者: 万乾炳
  • 作者简介:孟抒怀,住院医师,硕士,Email: 2323864889@qq.com
  • 基金资助:
    国家自然科学基金(81970984)

Research status on congenital syphilitic teeth

Meng Shuhuai(),Luo Feng,Pei Xibo,Wan Qianbing()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of ProsthodonticsⅠ, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2021-01-05 Revised:2021-04-02 Online:2021-07-01 Published:2021-06-30
  • Contact: Qianbing Wan
  • Supported by:
    National Natural Science Foundation of China(81970984)

摘要:

先天性梅毒牙是指由于梅毒螺旋体在胎儿出生前1个月至出生后1年感染牙胚,侵犯成釉器使牙齿的釉质发育障碍,导致釉质形成特征性发育不全的牙齿疾病的总称。先天性梅毒牙主要表现为恒切牙、第一恒磨牙出现釉质结构异常,因其特征性的临床表现,临床诊疗时易与某些釉质发育不全疾病相混淆,以致贻误患者的口腔及全身治疗。本文系统介绍了先天性梅毒牙的临床表现、病理改变与鉴别诊断,以期为先天性梅毒及先天性梅毒牙的早期诊治提供指导。

关键词: 先天性梅毒牙, 釉质结构异常, 鉴别诊断, 治疗

Abstract:

Congenital syphilitic teeth (CST) refers to the invasion of tooth germs by Treponema pallidum from 1 month before birth to 1 year after birth. CST invades the enamel organ and causes enamel development disorder, resulting in the formation of enamel hypoplasia, mainly in permanent incisors, and abnormal enamel structure of the first permanent molar. Given its characteristic clinical manifestations, enamel hypoplasia can easily be confused with other diseases in clinical practice, delaying the oral and systemic treatment of patients. This article systematically introduces the clinical manifestations, pathological changes, and differential diagnosis of CST to guide the early diagnosis and treatment of congenital syphilis and CST.

Key words: congenital syphilitic teeth, enamel structural abnormality, differential diagnosis, treatment

中图分类号: 

  • R780.2

图1

先天性梅毒牙中切牙(左)和尖牙(右)"

图2

蕾状磨牙(左)和桑葚状磨牙(右)"

[1] U.S. Preventive Services Task Force, Curry SJ, Krist AH, et al. Screening for syphilis infection in pregnant women: US preventive services task force reaffirmation recommendation statement[J]. JAMA, 2018,320(9):911-917.
doi: 10.1001/jama.2018.11785
[2] 中华人民共和国卫生健康委员会. 2019年全国法定报告传染病发病、死亡统计表[R/OL]. (2020-04-20) [2020-05-12]. http://www.nhc.gov.cn/jkj/s3578/2020041519e1bc1a944fc8ec176db600f68d1.shtml.
Health Commission of the People’s Republic of Chi-na. Statistics of incidence and death of notifiable in-fectious diseases in China in 2019[R/OL]. (2020-04-20) [2020-05-12]. http://www.nhc.gov.cn/jkj/s3578/2020041519e1bc1a944fc8ec176db600f68d1.shtml.
[3] Nelson R. Congenital syphilis and other STIs rise in the USA[J]. Lancet Infect Dis, 2018,18(11):1186-1187.
doi: 10.1016/S1473-3099(18)30618-2
[4] Nissanka-Jayasuriya EH, Odell EW, Phillips C. Dental stigmata of congenital syphilis: a historic review with present day relevance[J]. Head Neck Pathol, 2016,10(3):327-331.
doi: 10.1007/s12105-016-0703-z pmid: 26897633
[5] Wang YJ, Wu MZ, Gong XD, et al. Risk factors for congenital syphilis transmitted from mother to in-fant‒Suzhou, China, 2011-2014[J]. MMWR Morb Mortal Wkly Rep, 2019,68(10):247-250.
doi: 10.15585/mmwr.mm6810a4
[6] Mmeje O, Chow JM, Davidson L, et al. Discordant syphilis immunoassays in pregnancy: perinatal outcomes and implications for clinical management[J]. Clin Infect Dis, 2015,61(7):1049-1053.
doi: 10.1093/cid/civ445
[7] Binnicker MJ, Jespersen DJ, Rollins LO. Direct comparison of the traditional and reverse syphilis screening algorithms in a population with a low prevalence of syphilis[J]. J Clin Microbiol, 2012,50(1):148-150.
doi: 10.1128/JCM.05636-11
[8] Keuning MW, Kamp GA, Schonenberg-Meinema D, et al. Congenital syphilis, the great imitator‒case report and review[J]. Lancet Infect Dis, 2020,20(7):e173-e179.
doi: 10.1016/S1473-3099(20)30268-1
[9] Harper KN, Zuckerman MK, Harper ML, et al. The origin and antiquity of syphilis revisited: an appraisal of Old World pre-Columbian evidence for treponemal infection[J]. Am J Phys Anthropol, 2011,146(Suppl 53):99-133.
doi: 10.1002/ajpa.v146.53s
[10] Cooper JM, Sánchez PJ. Congenital syphilis[J]. Se-min Perinatol, 2018,42:176-184.
[11] Hutchinson J. Clinical lecture on heredito-syphilitic struma: and on the teeth as a means of diagnosis[J]. Br Med J, 1861,1(20):515-517.
pmid: 20743880
[12] Alfred F. Syphilitic teeth[J]. Dent Cosmos, 1884,26(1):12-25.
[13] Hillson S, Grigson C, Bond S. Dental defects of congenital syphilis[J]. Am J Phys Anthropol, 1998,107(1):25-40.
pmid: 9740299
[14] Ioannou S, Henneberg RJ, Henneberg M. Presence of dental signs of congenital syphilis in pre-modern specimens[J]. Arch Oral Biol, 2018,85:192-200.
doi: 10.1016/j.archoralbio.2017.10.017
[15] Moon H. On irregular and defective tooth development[J]. Trans Odontol Soc Great Britain, 1887,9:223-243.
[16] Bauer WH. Tooth buds and jaws in patients with congenital syphilis: correlation between distribution of treponema pallidum and tissue reaction[J]. Am J Pathol, 1944,20(2):297-319.
pmid: 19970756
[17] Reid DJ, Dean MC. Variation in modern human ena-mel formation times[J]. J Hum Evol, 2006,50(3):329-346.
pmid: 16300817
[18] Dean MC, Humphrey L, Groom A, et al. Variation in the timing of enamel formation in modern human deciduous canines[J]. Arch Oral Biol, 2020,114:104719.
doi: 10.1016/j.archoralbio.2020.104719
[19] Radu C, Soficaru AD. Dental developmental defects in a subadult from 16th‒19th centuries Bucharest, Romania[J]. Int J Paleopathol, 2016,15:33-38.
doi: 10.1016/j.ijpp.2016.08.001
[20] Kammoun R, Zmantar T, Labidi A, et al. Dental caries and hypoplastic amelogenesis imperfecta: clinical, structural, biochemical and molecular approaches[J]. Microb Pathog, 2019,135:103615.
doi: 10.1016/j.micpath.2019.103615
[21] Kim YJ, Kang J, Seymen F, et al. Alteration of exon definition causes amelogenesis imperfecta[J]. J Dent Res, 2020,99(4):410-418.
doi: 10.1177/0022034520901708
[22] Smith CE, Whitehouse LL, Poulter JA, et al. Defects in the acid phosphatase ACPT cause recessive hypoplastic amelogenesis imperfecta[J]. Eur J Hum Genet, 2017,25(8):1015-1019.
doi: 10.1038/ejhg.2017.79
[23] Bianchi ML. Hypophosphatasia: an overview of the disease and its treatment[J]. Osteoporos Int, 2015,26(12):2743-2757.
doi: 10.1007/s00198-015-3272-1 pmid: 26245849
[24] U.S. Department of Health and Human Services. Congenital syphilis‒2015 STD treatment guidelines[EB/OL]. (2015-06-04)[2020-09-12]. https://www.cdc.gov/std/tg2015/congenital.htm.
[25] Gaul JS, Grossschmidt K, Gusenbauer C, et al. A probable case of congenital syphilis from pre-Columbian Austria[J]. Anthropol Anz, 2015,72(4):451-472.
doi: 10.1127/anthranz/2015/0504
[26] Krämer N, Bui Khac NN, Lücker S, et al. Bonding strategies for MIH-affected enamel and dentin[J]. Dent Mater, 2018,34(2):331-340.
doi: 10.1016/j.dental.2017.11.015
[27] Crawford PJM, Aldred M, Blozh-Zupan A. Amelogenesis imperfecta[J]. Orphanet J Rare Dis, 2007,2(17):1750-1172.
[28] Seikaly H, Idris S, Chuka R, et al. The Alberta reconstructive technique: an occlusion-driven and di-gitally based jaw reconstruction[J]. Laryngoscope, 2019,129(Suppl 4):S1-S14.
[1] 刘世一, 陈中, 张素欣. 程序性死亡受体/配体免疫治疗策略在人乳头瘤病毒阳性头颈部鳞状细胞癌中的研究进展[J]. 国际口腔医学杂志, 2024, 51(1): 21-27.
[2] 和子慕, 李风兰. 数字化口腔定位支架在头颈部肿瘤放射治疗中的应用现状[J]. 国际口腔医学杂志, 2024, 51(1): 28-35.
[3] 傅豫, 何薇, 黄兰. 铁死亡在口腔疾病中的研究进展[J]. 国际口腔医学杂志, 2024, 51(1): 36-44.
[4] 韩冲,何东宁,余飞燕,吴东潮. 口腔种植术后疼痛机制及治疗的研究进展[J]. 国际口腔医学杂志, 2024, 51(1): 99-106.
[5] 胡佳,王秀清,卢国英,黄晓晶. 再生性牙髓治疗在成人根尖发育不全恒牙应用的研究进展[J]. 国际口腔医学杂志, 2023, 50(6): 686-695.
[6] 陆磊,王鑫,康泽标,谢富强. 计算机辅助导航手术在复杂颌面部骨折中的应用新进展[J]. 国际口腔医学杂志, 2023, 50(6): 696-703.
[7] 杨冬叶,朱萍,吴淑仪. 舌位的影响因素及临床意义[J]. 国际口腔医学杂志, 2023, 50(6): 723-728.
[8] 戢晓,张岚,黄定明. 牙源性与非牙源性上颌窦炎鉴别诊断及其治疗方案的研究进展[J]. 国际口腔医学杂志, 2023, 50(5): 566-572.
[9] 赵苑汐,苏勤. 根管再治疗中根管充填物去除辅助技术的应用与发展[J]. 国际口腔医学杂志, 2023, 50(5): 581-586.
[10] 宋文鹏,龚蓓文,李聃,曾剑玉,仇玲玲. 机械疗法在正畸治疗中应用的研究进展[J]. 国际口腔医学杂志, 2023, 50(5): 603-612.
[11] 刘婷,武秀萍. 唐氏综合征的口腔-颅颌面表征及治疗进展[J]. 国际口腔医学杂志, 2023, 50(5): 618-622.
[12] 吴思佳,舒畅,王洋,王媛,邓淑丽,王慧明. 根管内感染控制对年轻恒牙牙髓再生治疗的影响及研究进展[J]. 国际口腔医学杂志, 2023, 50(4): 388-394.
[13] 高宇天,苏勤. 酸性氧化电位水在根管治疗中的研究与应用[J]. 国际口腔医学杂志, 2023, 50(4): 401-406.
[14] 范琳,孙江. 微针在口腔医学中的应用[J]. 国际口腔医学杂志, 2023, 50(4): 472-478.
[15] 陈卓,石冰,李精韬. 唇腭裂患者外鼻生长特征的研究进展[J]. 国际口腔医学杂志, 2023, 50(3): 279-286.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] 张新春. 桩冠修复与无髓牙的保护[J]. 国际口腔医学杂志, 1999, 26(06): .
[2] 王昆润. 长期单侧鼻呼吸对头颅发育有不利影响[J]. 国际口腔医学杂志, 1999, 26(05): .
[3] 彭国光. 颈淋巴清扫术中颈交感神经干的解剖变异[J]. 国际口腔医学杂志, 1999, 26(05): .
[4] 杨凯. 淋巴化疗的药物运载系统及其应用现状[J]. 国际口腔医学杂志, 1999, 26(05): .
[5] 康非吾. 种植义齿下部结构生物力学研究进展[J]. 国际口腔医学杂志, 1999, 26(05): .
[6] 柴枫. 可摘局部义齿用Co-Cr合金的激光焊接[J]. 国际口腔医学杂志, 1999, 26(04): .
[7] 孟姝,吴亚菲,杨禾. 伴放线放线杆菌产生的细胞致死膨胀毒素及其与牙周病的关系[J]. 国际口腔医学杂志, 2005, 32(06): 458 -460 .
[8] 费晓露,丁一,徐屹. 牙周可疑致病菌对口腔黏膜上皮的粘附和侵入[J]. 国际口腔医学杂志, 2005, 32(06): 452 -454 .
[9] 赵兴福,黄晓晶. 变形链球菌蛋白组学研究进展[J]. 国际口腔医学杂志, 2008, 35(S1): .
[10] 庞莉苹,姚江武. 抛光和上釉对陶瓷表面粗糙度、挠曲强度及磨损性能的影响[J]. 国际口腔医学杂志, 2008, 35(S1): .