国际口腔医学杂志

国际口腔医学杂志 ›› 2020, Vol. 47 ›› Issue (3): 356-361.doi: 10.7518/gjkq.2020065

• 综述 • 上一篇    下一篇

味觉异常的病因和治疗研究进展

田国莉,江潞,陈谦明,曾昕()   

  1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心四川大学华西口腔医院口腔黏膜病科 成都 610041
  • 收稿日期:2019-09-05 修回日期:2020-04-07 出版日期:2020-05-01 发布日期:2020-05-08
  • 通讯作者: 曾昕 E-mail:zengxin22@163.com
  • 作者简介:田国莉,住院医师,硕士,Email：1051165418@qq.com
  • 基金资助:
    国家自然科学基金(81771081)

Research process on parageusia etiology and treatment

Tian Guoli,Jiang Lu,Chen Qianming,Zeng Xin()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Oral Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2019-09-05 Revised:2020-04-07 Online:2020-05-01 Published:2020-05-08
  • Contact: Xin Zeng E-mail:zengxin22@163.com
  • Supported by:
    National Natural Science Foundation of China(81771081)

RichHTML

20

PDF (PC)

227

摘要：

味觉异常是一种以味觉异常变化为特征的疾病,易导致患者出现食欲不振、体重减轻、营养不良,严重时甚至影响其身心健康,使其生活质量降低。味觉异常的病因、发病机制尚不明确,可能的致病因素较繁杂,目前尚无公认有效的检查方法和治疗方式。该类患者大多选择先于口腔科就诊。本文总结了现有研究下的味觉异常的定义、分类、病因、检查方法、治疗方式、预后,以及常见的伴发于其他疾病的味觉异常,为口腔临床医生对于该类患者的诊疗提供备选方案。

关键词: 味觉异常, 病因, 检查方法, 治疗

Abstract:

Parageusia is a disease characterized by abnormal taste changes and implicated in the loss of appetite, unintended weight loss, and malnutrition. Parageusia can even affect the physical and mental health and reduce the quality of life of the patient. Currently, the etiology and pathogenesis of parageusia are still ambiguous. The possible pathogenic factors are complicated. To the best of our knowledge, no recognized effective examination method and treatment is available. Dentists are often the first clinicians to be visited by patients with taste changes. This paper summarizes the definition, classification, etiology, pathogenesis, therapy, and prognosis of parageusia and the common parageusia associated with different systemic diseases to provide management options for dental clinicians.

Key words: parageusia, causes, examinations, therapy

中图分类号: 

  • R339.13
[1] Geran R, Uecker FC, Prüss H , et al. Olfactory and gustatory dysfunction in patients with autoimmune encephalitis[J]. Front Neurol, 2019,10:480.
doi: 10.3389/fneur.2019.00480 pmid: 31156532
[2] Lee EJ, Park WK, Nam JW , et al. Clinical charac-teristics of patients with taste disorders[J]. J Oral Med Pain, 2009,34(4):341-351.
[3] Walliczek-Dworschak U, Schöps F, Feron G , et al. Differences in the density of fungiform papillae and composition of saliva in patients with taste disorders compared to healthy controls[J]. Chem Senses, 2017,42(8):699-708.
doi: 10.1093/chemse/bjx054 pmid: 28981826
[4] Cowart BJ . Taste dysfunction: a practical guide for oral medicine[J]. Oral Dis, 2011,17(1):2-6.
doi: 10.1111/j.1601-0825.2010.01719.x pmid: 20796233
[5] Welge-Lüssen A . Re-establishment of olfactory and taste functions[J]. GMS Curr Top Otorhinolaryngol Head Neck Surg, 2005,4: Doc06.
pmid: 22073054
[6] Abu Bakr Elshafey Abd Elraouf, Hesham Abd El-Rahman, Ahmed Mohammed Mohammed El Refai , et al. Smell and taste disorders; recent management approaches[J]. J Am Sci, 2017,13(10):74-84.
doi: 10.2174/0929867325666180105102447 pmid: 29303074
[7] Syed Q, Hendler KT, Koncilja K . KThe impact of aging and medical status on dysgeusia[J]. Am J Med, 2016,129(7):753.e1-753.e6.
doi: 10.1016/j.amjmed.2016.02.003 pmid: 26899755
[8] Jetté M, Anderson C, Ramakrishnan V . Case report: diagnosis of hypogeusia after oral exposure to com-mercial cleaning agent and considerations for clinical taste testing[J]. F1000Res, 2017(6):373.
doi: 10.12688/f1000research.11241.2 pmid: 28713552
[9] van der Werf A, Rovithi M, Langius JAE , et al. In-sight in taste alterations during treatment with pro-tein kinase inhibitors[J]. Eur J Cancer, 2017,86:125-134.
doi: 10.1016/j.ejca.2017.09.006 pmid: 28987769
[10] Bergdahl M, Bergdahl J . Perceived taste disturbance in adults: prevalence and association with oral and psychological factors and medication[J]. Clin Oral Investig, 2002,6(3):145-149.
doi: 10.1007/s00784-002-0169-0 pmid: 12271346
[11] Kolkka-Palomaa M, Jääskeläinen SK, Laine MA , et al. Pathophysiology of primary burning mouth syn-drome with special focus on taste dysfunction: a review[J]. Oral Dis, 2015,21(8):937-948.
doi: 10.1111/odi.12345 pmid: 25962669
[12] Doty RL . Gustation[J]. Wiley Interdiscip Rev Cogn Sci, 2012,3(1):29-46.
doi: 10.1002/wcs.156 pmid: 26302471
[13] Mauri-Obradors E, Estrugo-Devesa A, Jané-Salas E , et al. Oral manifestations of diabetes mellitus. A systematic review[J]. Med Oral Patol Oral Cir Bucal, 2017,22(5):e586-e594.
doi: 10.4317/medoral.21655 pmid: 28809366
[14] Othieno F, Schlosser RJ, Rowan NR , et al. Taste impairment in chronic rhinosinusitis[J]. Int Forum Allergy Rhinol, 2018,8(7):783-789.
doi: 10.1002/alr.22113 pmid: 29569385
[15] Fitzgerald C, Wiese G, Moorthi RN , et al. Charac-terizing dysgeusia in hemodialysis patients[J]. Chem Senses, 2019,44(3):165-171.
doi: 10.1093/chemse/bjz001 pmid: 30629153
[16] Chandna S, Bathla M . Oral manifestations of thyroid disorders and its management[J]. Indian J Endocrinol Metab, 2011,15(Suppl 2):S113-S116.
doi: 10.4103/2230-8210.83343 pmid: 21966646
[17] Jajam M, Bozzolo P, Niklander S . Oral manifestations of gastrointestinal disorders[J]. J Clin Exp Dent, 2017,9(10):e1242-e1248.
doi: 10.4317/jced.54008 pmid: 29167716
[18] Noel C, Dando R . The effect of emotional state on taste perception[J]. Appetite, 2015,95:89-95.
doi: 10.1016/j.appet.2015.06.003 pmid: 26122754
[19] Methven L, Allen VJ, Withers CA , et al. Ageing and taste[J]. Proc Nutr Soc, 2012,71(4):556-565.
doi: 10.1017/S0029665112000742 pmid: 22883349
[20] Martin LJ, Sollars SI . Contributory role of sex dif-ferences in the variations of gustatory function[J]. J Neurosci Res, 2017,95(1/2):594-603.
doi: 10.1002/jnr.23819 pmid: 27870442
[21] Murtaza B, Hichami A, Khan AS , et al. Alteration in taste perception in cancer: causes and strategies of treatment[J]. Front Physiol, 2017,8:134.
doi: 10.3389/fphys.2017.00134 pmid: 28337150
[22] Giacomelli A, Pezzati L, Conti F , et al. Self-reported olfactory and taste disorders in SARS-CoV-2 patients: a cross-sectional study[J]. Clin Infect Dis, 2020. doi: 10.1093/cid/ciaa330.
[23] Just T, Steiner S, Pau HW . Oral pain perception and taste in burning mouth syndrome[J]. J Oral Pathol Med, 2010,39(1):22-27.
doi: 10.1111/j.1600-0714.2009.00824.x pmid: 19804504
[24] Imamura Y, Shinozaki T, Okada-Ogawa A , et al. An updated review on pathophysiology and management of burning mouth syndrome with endocrinological, psychological and neuropathic perspectives[J]. J Oral Rehabil, 2019,46(6):574-587.
doi: 10.1111/joor.12795 pmid: 30892737
[25] Braud A, Descroix V, Ungeheuer MN , et al. Taste function assessed by electrogustometry in burning mouth syndrome: a case-control study[J]. Oral Dis, 2017,23(3):395-402.
doi: 10.1111/odi.12630 pmid: 28029722
[26] Deshpande TS, Blanchard P, Wang L , et al. Radia-tion-related alterations of taste function in patients with head and neck cancer: a systematic review[J]. Curr Treat Options Oncol, 2018,19(12):72.
doi: 10.1007/s11864-018-0580-7 pmid: 30411162
[27] Ponticelli E, Clari M, Frigerio S , et al. Dysgeusia and health-related quality of life of cancer patients receiving chemotherapy: a cross-sectional study[J]. Eur J Cancer Care (Engl), 2017,26(2). DOI: 10.1111/ecc.12633.
[28] Negi P, Kingsley PA, Thomas M , et al. Pattern of gustatory impairment and its recovery after head and neck irradiation[J]. Iran J Otorhinolaryngol, 2017,29(95):319-327.
pmid: 29383312
[29] Sato T, Konuma T, Miwa Y , et al. A cross-sectional study on late taste disorders in survivors of allo-geneic hematopoietic cell transplantation[J]. Ann Hematol, 2017,96(11):1841-1847.
doi: 10.1007/s00277-017-3087-6 pmid: 28815326
[30] de Vries YC, Boesveldt S, Kelfkens CS , et al. Taste and smell perception and quality of life during and after systemic therapy for breast cancer[J]. Breast Cancer Res Treat, 2018,170(1):27-34.
doi: 10.1007/s10549-018-4720-3 pmid: 29476290
[31] Hummel T, Landis BN, Hüttenbrink KB . Smell and taste disorders[J]. GMS Curr Top Otorhinolaryngol Head Neck Surg, 2011,10:Doc04.
doi: 10.3205/cto000077 pmid: 22558054
[32] Cormie SE, Hirsch AR . 74 alpha lipoic acid respon-sive hypergeusia[J]. CNS Spectr, 2019,24(1):212-213.
[33] Kumbargere Nagraj S, George RP, Shetty N , et al. Interventions for managing taste disturbances[J]. Cochrane Database Syst Rev, 2017,12:CD010470.
doi: 10.1002/14651858.CD010470.pub3 pmid: 29260510
[34] Spanemberg JC, Segura-Egea JJ, Rodríguez-de Rivera-Campillo E , et al. Low-level laser therapy in patients with burning mouth syndrome: a double-blind, randomized, controlled clinical trial[J]. J Clin Exp Dent, 2019,11(2):e162-e169.
doi: 10.4317/jced.55517 pmid: 30805121
[1] 李继遥,郑广宁. 原发性牙根纵裂的诊治策略[J]. 国际口腔医学杂志, 2020, 47(4): 373-382.
[2] 张琳琳,杜毅. 畸形舌侧沟的治疗进展[J]. 国际口腔医学杂志, 2020, 47(4): 458-462.
[3] 张敏,万浩元. 种植体周围炎药物治疗与激光治疗的研究进展[J]. 国际口腔医学杂志, 2020, 47(4): 463-470.
[4] 吴秋月,李治邦. 药物辅助治疗种植体周围炎的研究进展[J]. 国际口腔医学杂志, 2020, 47(4): 471-477.
[5] 赵玉洁,管晓燕,李小兰,陈琦君,王倩,刘建国. 巨噬细胞极化参与正畸牙移动的研究进展[J]. 国际口腔医学杂志, 2020, 47(4): 478-483.
[6] 唐蓓,赵文俊,王虎,郑广宁,游梦. 根管超填导致下牙槽神经损伤2例[J]. 国际口腔医学杂志, 2020, 47(3): 293-296.
[7] 吴勇志,尧可,陈思宇,黄能文,王了. 多生牙及其诊断治疗[J]. 国际口腔医学杂志, 2020, 47(3): 311-317.
[8] 陈艺尹,刘俊圻,李承浩. 牙槽突裂的裂隙特点及正畸治疗对唇腭裂患者牙槽突植骨术的影响[J]. 国际口腔医学杂志, 2020, 47(3): 345-350.
[9] 于林彤,宋光泰. 铒激光在儿童口腔医学中的应用[J]. 国际口腔医学杂志, 2020, 47(3): 351-355.
[10] 陈斌,徐蓉蓉,张家鼎,闫福华. 重度牙周炎患牙的保存治疗[J]. 国际口腔医学杂志, 2020, 47(2): 125-130.
[11] 蔡潇潇. 美学区数字化种植策略与流程[J]. 国际口腔医学杂志, 2019, 46(6): 621-630.
[12] 陈东,杨征,蒋丽. 放射性口腔干燥症的评估与临床管理的研究进展[J]. 国际口腔医学杂志, 2019, 46(6): 711-717.
[13] 宋少华,莫水学. 唇腭裂患者序列治疗中的正畸治疗[J]. 国际口腔医学杂志, 2019, 46(6): 740-744.
[14] 许庆安,樊明文. 非器械根管治疗与多声波超洁净系统[J]. 国际口腔医学杂志, 2019, 46(5): 522-525.
[15] 卫彬彬,肖苗,孙哲,衣玉丽. 鼻咽癌放射治疗联合化学治疗所致口腔黏膜炎的防治[J]. 国际口腔医学杂志, 2019, 46(5): 558-564.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] 王昆润. 在种植体上制作固定义齿以后下颌骨密度的动态变化[J]. 国际口腔医学杂志, 1999, 26(06): .
[2] 陆加梅. 不可复性关节盘移位患者术前张口度与关节镜术后疗效的相关性[J]. 国际口腔医学杂志, 1999, 26(06): .
[3] 高卫民,李幸红. 发达国家牙医学院口腔种植学教学现状[J]. 国际口腔医学杂志, 1999, 26(06): .
[4] 张新春. 桩冠修复与无髓牙的保护[J]. 国际口腔医学杂志, 1999, 26(06): .
[5] 王昆润. 长期单侧鼻呼吸对头颅发育有不利影响[J]. 国际口腔医学杂志, 1999, 26(05): .
[6] 潘劲松. 颈总动脉指压和颈内动脉球囊阻断试验在大脑血液动力学中的不同影响[J]. 国际口腔医学杂志, 1999, 26(05): .
[7] 彭国光. 颈淋巴清扫术中颈交感神经干的解剖变异[J]. 国际口腔医学杂志, 1999, 26(05): .
[8] 王昆润. 后牙冠根斜形牙折的治疗[J]. 国际口腔医学杂志, 1999, 26(05): .
[9] 轩东英. 不同赋形剂对氢氧化钙抗菌效果的影响[J]. 国际口腔医学杂志, 1999, 26(05): .
[10] 杨凯. 淋巴化疗的药物运载系统及其应用现状[J]. 国际口腔医学杂志, 1999, 26(05): .