国际口腔医学杂志 ›› 2019, Vol. 46 ›› Issue (6): 724-729.doi: 10.7518/gjkq.2019089

• 综述 • 上一篇    下一篇

促红细胞生成素肝细胞激酶受体及其膜结合配体对牙槽骨改建作用的研究进展

王琳璇1,王琦1,赵云1,米方林1,2()   

  1. 1. 川北医学院口腔医学系 南充 637000
    2. 川北医学院附属医院口腔科 南充 637000
  • 收稿日期:2019-01-05 修回日期:2019-06-28 出版日期:2019-11-01 发布日期:2019-11-14
  • 通讯作者: 米方林 E-mail:mfl126@126.com
  • 作者简介:王琳璇,医师,硕士,Email: 364632216@qq.com
  • 基金资助:
    四川省教育厅科研项目(15ZA0210);南充市研发资金项目(16YFZJ0123);南充市市校科技战略合作专项基金(NSMC2017- 0442)

Research progress of erythropoietin-producing hepatocyte kinase receptor and ephrin ligand in alveolar bone remodeling

Wang Linxuan1,Wang Qi1,Zhao Yun1,Mi Fanglin1,2()   

  1. 1. Dept. of Stomatology, North Sichuan Medical College, Nanchong 637000, China
    2. Dept. of Stomatology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China
  • Received:2019-01-05 Revised:2019-06-28 Online:2019-11-01 Published:2019-11-14
  • Contact: Fanglin Mi E-mail:mfl126@126.com
  • Supported by:
    This study was supported by Scientific Research Project of Sichuan Education Department(15ZA0210);Research and Development Fund Project of Nanchong(16YFZJ0123);Science and Technology Strategic Cooperation between City and School of Nanchong(NSMC2017- 0442)

摘要:

促红细胞生成素肝细胞激酶受体及其膜结合配体(ephrin/Eph)是除核因子κB受体活化因子配体/核因子κB受体活化因子/骨保护素(RANKL/RANK/OPG)外与骨改建相关的新的信号通路。在牙槽骨改建过程中ephrin/Eph相关因子不仅与骨细胞之间的相互作用相关,同时还受牙周膜细胞的影响。与正常骨组织相比,牙槽骨组织改建过程中相关因子表达存在明显差异,这说明了ephrin/Eph相关因子对骨改建过程的调控具有复杂性和重要性。本文就ephrin/Eph通路在骨细胞与牙周膜成纤维细胞中的相互作用进而参与牙槽骨改建的研究进展进行综述。

关键词: 促红细胞生成素肝细胞激酶受体, 促红细胞生成素肝细胞激酶受体膜结合配体, 牙槽骨, 骨改建, 牙周膜

Abstract:

The erythropoietin producing hepatocyte kinase receptor and ephrin ligand (ephrin/Eph) are new signal pathways associated with bone remodeling in addition to the receptor activator for nuclear factor-κB ligand/receptor activator for nuclear factor-κB/osteoprotegenin (RANKL/RANK/OPG). In alveolar bone remodeling, ephrin/Eph-related factors are not only related to the interaction between bone cells but also affected by periodontal ligament cells. The expression of related factors in the process of alveolar bone tissue remodeling is substantially different from that for normal bone tissue. This difference reveals the complexity and importance of ephrin/Eph-related factors in the regulation of bone remodeling. This study reviews the research progress on the interaction of the ephrin/Eph pathway between bone cells and periodontal ligament cells to participate in alveolar bone remodeling.

Key words: erythropoietin producing hepatocyte kinase receptor, erythropoietin producing hepatocyte kinase ligand, alveolar bone, bone remodeling, periodontal ligament

中图分类号: 

  • Q26
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