国际口腔医学杂志

国际口腔医学杂志 ›› 2019, Vol. 46 ›› Issue (3): 316-319.doi: 10.7518/gjkq.2019021

• 综述 • 上一篇    下一篇

骨保护素在口腔领域的研究进展

高鑫,曾融生()   

  1. 广东省口腔医学重点实验室 广州 510055
  • 收稿日期:2018-06-06 修回日期:2018-12-13 出版日期:2019-05-01 发布日期:2019-06-05
  • 通讯作者: 曾融生 E-mail:rszeng@yahoo.ca
  • 作者简介:高鑫,学士,Email：2862499361@qq.com
  • 基金资助:
    国家自然科学基金(81070818)

Research progress on osteoprotegerin in oral science

Xin Gao,Rongsheng Zeng()   

  1. Dept. of Maxillofacial Surgery, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China
  • Received:2018-06-06 Revised:2018-12-13 Online:2019-05-01 Published:2019-06-05
  • Contact: Rongsheng Zeng E-mail:rszeng@yahoo.ca
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81070818)

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摘要：

骨保护素（OPG）作为肿瘤坏死因子家族的新成员,通过核因子-κB受体活化因子配体（RANKL）/核因子-κB受体活化因子（RANK）/OPG信号通路有效抑制破骨细胞分化和成熟,而破骨细胞直接参与骨代谢的调节,在牙槽骨重建和牙根吸收过程中起主要作用。本文就OPG对正畸牙移动、牙周炎、种植体骨结合和牙萌出等方面的研究进展进行综述。

关键词: 骨保护素, 破骨细胞, 牙槽骨重建, 牙根吸收, 骨结合

Abstract:

Known as a new member of the tumour necrosis factor receptor superfamily, osteoprotegerin (OPG) inhibits osteoclastogenesis and osteoclast activation through the receptor-activator of nuclear factor-κB ligand (RANKL)/receptor-activator of nuclear factor-κB (RANK)/OPG signal pathway. Additionally, osteoclasts are directly involved in the regulation of bone metabolism and play a major role in alveolar bone reconstruction and root resorption. This review focused on the implications of osteoprotegerin during orthodontic tooth movement, periodontitis, osteointegration, tooth eruption and other oral aspects.

Key words: osteoprotegerin, osteoclast, alveolar bone reconstruction, root resorption, osteointegration

中图分类号: 

  • Q257
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