国际口腔医学杂志

国际口腔医学杂志 ›› 2017, Vol. 44 ›› Issue (3): 267-272.doi: 10.7518/gjkq.2017.03.004

• 牙体牙髓专栏 • 上一篇    下一篇

年轻恒牙牙髓再生的临床应用进展

雷期音, 陈柯   

  1. 暨南大学口腔医学院 广州市妇女儿童医疗中心口腔医学中心 广州 510000
  • 收稿日期:2016-11-07 修回日期:2017-02-07 出版日期:2017-05-01 发布日期:2017-05-01
  • 通讯作者: 陈柯,主任医师,硕士,Email：dentchenke@sohu.com
  • 作者简介:雷期音,医师,硕士,Email：xy1400@163.com
  • 基金资助:
    广州市科技计划项目（201510010160）

Research progress on the clinical treatment of regenerative endodontics in immature permanent teeth

Lei Qiyin, Chen Ke.   

  1. School of Stomatology, Jinan University;Dept. of Stomatology, Guangzhou Women and Children’s Medical Center, Guangzhou 510000, China
  • Received:2016-11-07 Revised:2017-02-07 Online:2017-05-01 Published:2017-05-01
  • Supported by:
    This study was supported by the Science & Technology Development Foundation of Guangzhou(201510010160).

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摘要： 目前,对于未发育成熟、根尖孔未闭合的牙髓坏死和根尖周炎的年轻恒牙,临床上主要的治疗方法为根尖诱导成形术,但根尖诱导成形术预后发生根折的概率较大。随着牙髓再生术临床成功病例报告的逐渐增多,越来越多的患者接受牙髓再生治疗。本文收集国外2010—2015年的35篇文献92例病例进行总结并分析,对牙髓再生术的临床应用进展作一综述。

关键词: 年轻恒牙, 牙髓坏死, 根尖周炎, 牙髓再生

Abstract: Currently, the main treatment of pulp necrosis and apical periodontitis in immature permanent teeth with open apex is apexification, which has the high rate in root fracture in prognosis. Recently, with the success cases of the regenerative endodontics gradually increased, more patients were willing to receive it. About 35 papers, 92 cases and reports were collected and analyzed. The progress of regenerative endodontics applied in clinical treatment was summarized in this paper.

Key words: immature permanent teeth, pulp necrosis, apical periodontitis, regenerative endodontics

中图分类号: 

  • R781.05
[1] Iwaya SI, Ikawa M, Kubota M. Revascularization of an immature permanent tooth with apical periodon-titis and sinus tract[J]. Dent Traumatol, 2001, 17(4): 185-187.
[2] Chueh LH, Huang GT. Immature teeth with perira-dicular periodontitis or abscess undergoing apexo-genesis: a paradigm shift[J]. J Endod, 2006, 32(12): 1205-1213.
[3] Thomson A, Kahler B. Regenerative endodontics—biologically-based treatment for immature permanent teeth: a case report and review of the literature[J]. Aust Dent J, 2010, 55(4):446-452.
[4] Kim JH, Kim Y, Shin SJ, et al. Tooth discoloration of immature permanent incisor associated with triple antibiotic therapy: a case report[J]. J Endod, 2010, 36(6):1086-1091.
[5] Petrino JA, Boda KK, Shambarger SA, et al. Cha-llenges in regenerative endodontics: a case series[J]. J Endod, 2010, 36(3):536-541.
[6] Iwaya S, Ikawa M, Kubota M. Revascularization of an immature permanent tooth with periradicular abscess after luxation[J]. Dent Traumatol, 2011, 27 (1):55-58.
[7] Jung IY, Kim ES, Lee CY, et al. Continued develo-pment of the root separated from the main root[J]. J Endod, 2011, 37(5):711-714.
[8] Torabinejad M, Turman M. Revitalization of tooth with necrotic pulp and open apex by using platelet-rich plasma: a case report[J]. J Endod, 2011, 37(2): 265-268.
[9] Nosrat A, Seifi A, Asgary S. Regenerative endo-dontic treatment(revascularization) for necrotic immature permanent molars: a review and report of two cases with a new biomaterial[J]. J Endod, 2011, 37(4):562-567.
[10] Chen MY, Chen KL, Chen CA, et al. Responses of immature permanent teeth with infected necrotic pulp tissue and apical periodontitis/abscess to reva-scularization procedures[J]. Int Endod J, 2012, 45(3): 294-305.
[11] Nosrat A, Homayounfar N, Oloomi K. Drawbacks and unfavorable outcomes of regenerative endodon-tic treatments of necrotic immature teeth: a literature review and report of a case[J]. J Endod, 2012, 38 (10):1428-1434.
[12] Lenzi R, Trope M. Revitalization procedures in two traumatized incisors with different biological out-comes[J]. J Endod, 2012, 38(3):411-414.
[13] Torabinejad M, Faras H. A clinical and histological report of a tooth with an open apex treated with regenerative endodontics using platelet-rich plasma [J]. J Endod, 2012, 38(6):864-868.
[14] Aggarwal V, Miglani S, Singla M. Conventional apexification and revascularization induced maturo-genesis of two non-vital, immature teeth in same patient: 24 months follow up of a case[J]. J Conserv Dent, 2012, 15(1):68-72.
[15] Keskin C, Demiryurek EO, Ozyurek T. Color stabi-lities of calcium silicate-based materials in contact with different irrigation solutions[J]. J Endod, 2015, 41(3):409-411.
[16] Kim DS, Park HJ, Yeom JH, et al. Long-term follow-ups of revascularized immature necrotic teeth: three case reports[J]. Int J Oral Sci, 2012, 4(2):109-113.
[17] Narayana P, Hartwell GR, Wallace R, et al. Endo-dontic clinical management of a dens invaginatus case by using a unique treatment approach: a case report[J]. J Endod, 2012, 38(8):1145-1148.
[18] Paryani K, Kim SG. Regenerative endodontic treat-ment of permanent teeth after completion of root development: a report of 2 cases[J]. J Endod, 2013, 39(7):929-934.
[19] Guimarães BM, Tartari T, Marciano MA, et al. Color stability, radiopacity, and chemical characteristics of white mineral trioxide aggregate associated with 2 different vehicles in contact with blood[J]. J Endod, 2015, 41(6):947-952.
[20] Martin G, Ricucci D, Gibbs JL, et al. Histological findings of revascularized/revitalized immature permanent molar with apical periodontitis using platelet-rich plasma[J]. J Endod, 2013, 39(1):138- 144.
[21] Soares Ade J, Lins FF, Nagata JY, et al. Pulp reva-scularization after root canal decontamination with calcium hydroxide and 2% chlorhexidine gel[J]. J Endod, 2013, 39(3):417-420.
[22] Shimizu E, Ricucci D, Albert J, et al. Clinical, radio-graphic, and histological observation of a human immature permanent tooth with chronic apical ab-scess after revitalization treatment[J]. J Endod, 2013, 39(8):1078-1083.
[23] Keswani D, Pandey RK. Revascularization of an immature tooth with a necrotic pulp using platelet-rich fibrin: a case report[J]. Int Endod J, 2013, 46 (11):1096-1104.
[24] Forghani M, Parisay I, Maghsoudlou A. Apexoge-nesis and revascularization treatment procedures for two traumatized immature permanent maxillary incisors: a case report[J]. Restor Dent Endod, 2013, 38(3):178-181.
[25] Kottoor J, Velmurugan N. Revascularization for a necrotic immature permanent lateral incisor: a case report and literature review[J]. Int J Paediatr Dent, 2013, 23(4):310-316.
[26] Yang J, Zhao Y, Qin M, et al. Pulp revascularization of immature dens invaginatus with periapical perio-dontitis[J]. J Endod, 2013, 39(2):288-292.
[27] Chen X, Bao ZF, Liu Y, et al. Regenerative endo-dontic treatment of an immature permanent tooth at an early stage of root development: a case report[J]. J Endod, 2013, 39(5):719-722.
[28] Jadhav GR, Shah N, Logani A. Comparative out-come of revascularization in bilateral, non-vital, immature maxillary anterior teeth supplemented with or without platelet rich plasma: a case series[J]. J Conserv Dent, 2013, 16(6):568-572.
[29] Bezgin T, Yilmaz AD, Celik BN, et al. Concentrated platelet-rich plasma used in root canal revasculariza-tion: 2 case reports[J]. Int Endod J, 2014, 47(1):41- 49.
[30] Becerra P, Ricucci D, Loghin S, et al. Histologic study of a human immature permanent premolar with chronic apical abscess after revascularization/revitalization[J]. J Endod, 2014, 40(1):133-139.
[31] Lin LM, Shimizu E, Gibbs JL, et al. Histologic and histobacteriologic observations of failed revascu-larization/revitalization therapy: a case report[J]. J Endod, 2014, 40(2):291-295.
[32] Jadhav G, Shah N, Logani A. Revascularization with and without platelet-rich plasma in nonvital, imma-ture, anterior teeth: a pilot clinical study[J]. J Endod, 2012, 38(12):1581-1587.
[33] Amit V, Jain A, Nayak UA, et al. Maturogenesis by revascularization in an infected immature permanent tooth[J]. J Indian Soc Pedod Prev Dent, 2014, 32(2): 172-175.
[34] Nagata JY, Gomes BP, Rocha Lima TF, et al. Traumatized immature teeth treated with 2 protocols of pulp revascularization[J]. J Endod, 2014, 40(5): 606-612.
[35] Park M, Ahn BD. Immature permanent teeth with apical periodontitis and abscess treated by regenera-tive endodontic treatment using calcium hydroxide and MTA: a report of two cases[J]. Pediatr Dent, 2014, 36(3):107-110.
[36] Jadhav GR, Shah N, Logani A. Platelet-rich plasma supplemented revascularization of an immature tooth associated with a periapical lesion in a 40-year-old man[J]. Case Rep Dent, 2014, 2014:479584.
[37] Hargreaves KM, Diogenes A, Teixeira FB. Treat-ment options: biological basis of regenerative endo-dontic procedures[J]. J Endod, 2013, 39(3 Suppl):S30-S43.
[38] Berkhoff JA, Chen PB, Teixeira FB, et al. Evaluation of triple antibiotic paste removal by different irriga-tion procedures[J]. J Endod, 2014, 40(8):1172-1177.
[39] Ruparel NB, Teixeira FB, Ferraz CC, et al. Direct effect of intracanal medicaments on survival of stem cells of the apical papilla[J]. J Endod, 2012, 38(10): 1372-1375.
[40] Banchs F, Trope M. Revascularization of immature permanent teeth with apical periodontitis: new treat-ment protocol[J]. J Endod, 2004, 30(4):196-200.
[41] Akcay M, Arslan H, Yasa B, et al. Spectrophotome-tric analysis of crown discoloration induced by various antibiotic pastes used in revas-cularization[J]. J Endod, 2014, 40(6):845-848.
[42] Zhu W, Zhu X, Huang GT, et al. Regeneration of dental pulp tissue in immature teeth with apical periodontitis using platelet-rich plasma and dental pulp cells[J]. Int Endod J, 2013, 46(10):962-970.
[43] Marciano MA, Costa RM, Camilleri J, et al. Assess-ment of color stability of white mineral trioxide aggregate angelus and bismuth oxide in contact with tooth structure[J]. J Endod, 2014, 40(8):1235-1240.
[44] El Ashry SH, Abu-Seida AM, Bayoumi AA, et al. Regenerative potential of immature permanent non-vital teeth following different dentin surface treat-ments[J]. Exp Toxicol Pathol, 2016, 68(2/3):181- 190.
[45] Saoud TM, Mistry S, Kahler B, et al. Regenerative endodontic procedures for traumatized teeth after horizontal root fracture, avulsion, and perforating root resorption[J]. J Endod, 2016, 42(10):1476-1482.
[46] Poorni S, Srinivasan MR, Duraivel D, et al. Treat-ment outcome with a revascularization protocol using double and triple antibiotic pastes in immature nec-rotic teeth—a double blinded randomized control clinical trial[J]. J Pierre Fauch Acad (India Sec), 2017. [Epub ahead of print].
[47] Kahler B, Rossi-Fedele G. A review of tooth disco-loration after regenerative endodontic therapy[J]. J Endod, 2016, 42(4):563-569.
[48] Topçuoğlu G, Topçuoğlu HS. Regenerative endo-dontic therapy in a single visit using platelet-rich plasma and biodentine in necrotic and asymptomatic immature molar teeth: a report of 3 cases[J]. J En-dod, 2016, 42(9):1344-1346.
[49] Bakhtiar H, Esmaeili S, Fakhr Tabatabayi S, et al. Second-generation platelet concentrate (platelet-rich fibrin) as a scaffold in regenerative endodontics: a case series[J]. J Endod, 2017, 43(3):401-408.
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