国际口腔医学杂志 ›› 2016, Vol. 43 ›› Issue (3): 357-360.doi: 10.7518/gjkq.2016.03.023

• 综述 • 上一篇    下一篇

转换蛋白2及其调节和生理病理作用

宁毅1,郑晓旭2,孙睿3   

  1. 1.山西医科大学口腔医学系 太原 030001;2.马里兰大学医学院附属医院肾内科 巴尔的摩 21201;3.山西省人民医院口腔颌面外科 太原 030012
  • 收稿日期:2015-06-06 修回日期:2016-02-02 出版日期:2016-05-01 发布日期:2016-05-01
  • 通讯作者: 孙睿,副教授,博士,Email:ruidoctor@163.com
  • 作者简介:宁毅,硕士,Email:ningyi19870608@163.com
  • 基金资助:
    山西省自然科学基金(2011011037)

Role of transformer 2 regulation and its physiological and pathological significance

Ning Yi1, Zheng Xiaoxu2, Sun Rui3   

  1. 1. College of Stomatology, Shanxi Medical University, Taiyuan 030001, China; 2. Dept. of Nephrology, Affiliated Hospital of Medical College, University of Maryland, Baltimore 21201, America; 3. Dept.of Oral and Maxillofacial Surgery, Shanxi Provincial People’s Hospital, Taiyuan 030012, China) This study was supported by the Natural Science Foundation of Shanxi Province(2011011037).
  • Received:2015-06-06 Revised:2016-02-02 Online:2016-05-01 Published:2016-05-01

摘要: 转换蛋白(TRA)2为前体mRNA剪接蛋白,是一族富含丝氨酸-精氨酸重复剪接因子(SR)家族的相关蛋白,包括TRA2α和TRA2β两个亚族。它们在结构上与SR蛋白有着一定的相似性,在功能上与SR蛋白有着明显的差异,即TRA2蛋白不为组成性剪接所必需,但在选择性前体mRNA剪接中决定剪接位点方面却起着重要的作用。在哺乳动物中,TRA2蛋白家族在生理和病理过程中发挥着诸多关键性作用,且在疾病的发生发展过程中错误地调控剪接过程产生异常的RNA可引起分子病或者导致原来的疾病更加严重。迄今为止,人们还不清楚TRA2蛋白与疾病间的关系,所以对其引起疾病的治疗研究还处在初级阶段。

关键词: 转换蛋白, 前体mRNA剪接蛋白, 生理病理作用, 疾病防治, 转换蛋白, 前体mRNA剪接蛋白, 生理病理作用, 疾病防治

Abstract: The transformer(TRA)2 protein belongs to the serine/arginine-rich(SR) protein family. The protein possesses two homologs, namely, TRA2α and TRA2β. These homologs exhibit structures similar to those of the SR proteins but significantly differ in function. TRA2 is not necessarily implicated in composition splicing but plays an important role in selecting the splicing sites of precursor mRNA. Further studies found that in mammals, the TRA2 family protein plays a key role in many physiological and pathological, as well as disease occurrence and development, processes. Moreover, the abnormal splicing process of RNA molecules can cause disease or aggravate existing pathological problems. However, the relationship between TRA2 proteins and diseases remains to be completely understood. Additional energy and effort are required to achieve success in investigating disease causes and in developing treatments.

Key words: transformer, precursor mRNA splicing protein, physiological and pathological effect, disease control, transformer, precursor mRNA splicing protein, physiological and pathological effect, disease control

中图分类号: 

  • Q 51
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