Int J Stomatol

Inter J Stomatol ›› 2014, Vol. 41 ›› Issue (6): 720-724.doi: 10.7518/gjkq.2014.06.025

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Transforming growth factor β signaling pathway and its potential in regulating the components and functions of vascular vessels

Zhong Wenqun1, Chen Gang1,2, Zhao Yifang2   

  1. 1. The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, China; 2. Dept. of Oral and Maxillofacial Surgery, Hospital of Stomatology, Wuhan University, Wuhan 430079, China
  • Online:2014-11-01 Published:2014-11-01

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Abstract:

Transforming growth factor(TGF)β, a growth factor secreted by different cells, has been demonstrated to possess a variety of biological effects. Recent evidence has associated the TGFβ signaling pathway withthe regulation of angiogenesis and vascular stability. Extensive studies on the signaling pathway of TGFβ and its potential role in vascular regulation have been reported. In this review, the effects of the TGFβ signaling pathway on the regulation of vascular endothelial cells, smooth muscle cells, and vascular membrane, are discussed.

Key words: transforming growth factor, signal transduction pathway, vascular endothelial cell, vascular smooth muscle cell, vascular basement membrane


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