Int J Stomatol

Int J Stomatol ›› 2025, Vol. 52 ›› Issue (5): 655-661.doi: 10.7518/gjkq.2025084

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Immune regulation mediated by extracellular vesicles from dental-derived mesenchymal stem cells

Boqun Wang(),Hui Lu,Qing Mu,Wei Zhao()   

  1. Dept. of Pediatric Dentistry, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University & Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China
  • Received:2024-07-11 Revised:2025-06-29 Online:2025-09-01 Published:2025-08-27
  • Contact: Wei Zhao E-mail:wangbq9@mail2.sysu.edu.cn;zhaowei3@mail.sysu.edu.cn
  • Supported by:
    Natural Science Foundation of Guangdong Province(2023A1515012554);Student Innovation and Entrepreneurship Training Program of Sun Yat-sen University(20240491)

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Abstract:

Extracellular vesicles (EVs) released by stem cells carry various bioactive molecules that are essential for mediating intercellular communication. Compared with other tissues-derived stem cells, mesenchymal stem cells derived from dental tissues possess several unique advantages, including accessibility, proliferative capacity, and immunomodulatory potential. EVs secreted by these mesenchymal stem cells have been shown to influence immune cell function and modulate inflammatory responses within local cellular and tissue environments. These immunoregulatory properties are particularly relevant in the context of inflammation-related diseases resulting from trauma, infection, and other pathological stimuli, highlighting the potential of these EVs in tissue repair and regenerative medicine. This review focuses on the immunomodulatory roles of EVs from mesenchymal stem cells derived from dental tissues and their regulatory functions in oral and systemic inflammatory diseases.

Key words: extracellular vesicle, dental-derived mesenchymal stem cell, immune regulation

CLC Number: 

  • Q254

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