Int J Stomatol

Inter J Stomatol ›› 2016, Vol. 43 ›› Issue (2): 172-176.doi: 10.7518/gjkq.2016.02.013

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Roles of pathogen-associated and damage-associated molecular patterns in immune inflammatory response

Ding Ye1, Ren Jingyi1, Yu Hongqiang1, Zhou Yanmin1, Yu Weixian2   

  1. 1. Dept. of Implant Center, Hospital of Stomatology, Jilin University, Changchun 130021, China; 2. Key Laboratory of Mechanism of Tooth Development and Jaw Bone Remodeling and Regeneration in Jilin Province, Changchun 130021, China)
  • Received:2015-10-20 Revised:2015-12-01 Online:2016-03-01 Published:2016-03-01

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Abstract: Pathogen-associated molecular patterns(PAMP) and damage-associated molecular patterns(DAMP) are two molecules closely linked to immunology. DAMP are defined as a class of substances released to the cell or blood supply upon stimulation by tissue damage, cell hypoxia, or other factors. PAMP form the molecular structure of the pathogen. Both of these molecules are identified by pattern recognition receptors, which leads to the immune response. To date, research shows that DAMP and PAMP are associated with chronic inflammatory and autoimmune diseases. This thesis will summarize the roles of PAMP and DAMP molecules in immune inflammatory response.

Key words: pathogen-associated molecular pattern, damage-associated molecular pattern, pattern recognition receptor, immune inflammatory response, pathogen-associated molecular pattern, damage-associated molecular pattern, pattern recognition receptor, immune inflammatory response

CLC Number: 

  • Q 753

TrendMD: 
[1] Zhu J, Mohan C. Toll-like receptor signaling pathways—therapeutic opportunities[J]. Mediators Inflamm, 2010:781235.
[2] Miyaji EN, Carvalho E, Oliveira ML, et al. Trends in adjuvant development for vaccines: DAMPs and PAMPs as potential new adjuvants[J]. Braz J Med Biol Res, 2011, 44(6):500-513.
[3] Tang D, Kang R, Coyne CB, et al. PAMPs and DAMPs: signal 0s that spur autophagy and immunity[J]. Immunol Rev, 2012, 249(1):158-175.
[4] Sa?d-Sadier N, Ojcius DM. Alarmins, inflammasomes and immunity[J]. Biomed J, 2012, 35(6):437-449.
[5] 王岚, 夏佳佳, 刘琪, 等. 脂多糖对人牙周膜干细胞增殖及炎性因子表达的影响[J]. 华西口腔医学杂志, 2013, 31(3):286-290. Wang L, Xia JJ, Liu Q, et al. Effect of lipopolysaccharide on proliferation and inflammatory factors expression of human periodontal ligament stem cells[J]. West China J Stomatol, 2013, 31(3):286-290.
[6] Choi S, Baik JE, Jeon JH, et al. Identification of Porphyromonas gingivalis lipopolysaccharide-binding proteins in human saliva[J]. Mol Immunol, 2011, 48 (15/16):2207-2213.
[7] Pisetsky DS. The origin and properties of extracellular DNA: from PAMP to DAMP[J]. Clin Immunol, 2012, 144(1):32-40.
[8] Jounai N, Kobiyama K, Takeshita F, et al. Recognition of damage-associated molecular patterns related to nucleic acids during inflammation and vaccination[J]. Front Cell Infect Microbiol, 2012, 2:168.
[9] Eigenbrod T, Franchi L, Mu?oz-Planillo R, et al. Bacterial RNA mediates activation of caspase-1 and IL-1β release independently of TLRs 3, 7, 9 and TRIF but is dependent on UNC93B[J]. J Immunol, 2012, 189(1):328-336.
[10] Sander LE, Davis MJ, Boekschoten MV, et al. Detection of prokaryotic mRNA signifies microbial viability and promotes immunity[J]. Nature, 2011, 474(7351):385-389.
[11] Mourao-Sa D, Roy S, Blander JM. Vita-PAMPs: signatures of microbial viability[J]. Adv Exp Med Biol, 2013, 785:1-8.
[12] Lozano-Durán R, Bourdais G, He SY, et al. The bacterial effector HopM1 suppresses PAMP-triggered oxidative burst and stomatal immunity[J]. New Phytol, 2014, 202(1):259-269.
[13] Rubartelli A, Lotze MT. Inside, outside, upside down: damage-associated molecular-pattern molecules (DAMPs) and redox[J]. Trends Immunol, 2007, 28(10):429-436.
[14] Hirsiger S, Simmen HP, Werner CM, et al. Danger signals activating the immune response after trauma [J]. Mediators Inflamm, 2012:315941.
[15] Wakefield D, Gray P, Chang J, et al. The role of PAMPs and DAMPs in the pathogenesis of acute and recurrent anterior uveitis[J]. Br J Ophthalmol, 2010, 94(3):271-274.
（本文采编 王晴）
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