Int J Stomatol

Inter J Stomatol ›› 2007, Vol. 34 ›› Issue (05): 325-327.

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Significance and expression of E-cad and CD44v6 in oral and maxillofacial squamous cell carcinoma

LIU Yi- shan1, LING Bin2, MA Xu- dong3, WANG Shan- zheng3, LIN Zhao- quan2, LIU Geng3.   

  1. 1. Dept. of Stomatology, The First Affiliated Hospital of Xinjiang Medical University，Urumqi 830054, China; 2. Dept. of Oral Maxillofacial Surgery, The First Affiliated Hospital of Xinjiang Medical University，Urumqi 830054, China; 3. Key. Laboratory, The First Affiliated Hospital of Xinjiang Medical University，Urumqi 830054, China
  • Online:2007-09-20 Published:2007-09-20

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Abstract:

Objective To investigate the role of the adhesion molecule E- cad and CD44v6, and the relationship between the expression of E- cad and CD44v6 and the histopathological grade and lymph nodes metastasis in oral and maxillofacial squamous cell carcinoma（SCC）. Methods Immunohistochemical method（LSAB） was applied to examine the expression of E- cad and CD44v6 in 54 oral and maxillofacial SCC and 15 non- cancerous tissues. Results E - cad expression was positive in 50.00% of SCC versus in 86.67% of non - can cerous tissues. The positive rate of E- cad in SCC was lower than that in non- cancerous tissues（P<0.05）. Unusual expression of E- cad and CD44v6 was significantly correlated with histopathological grade（P<0.05）. The oral and maxillofacial SCC with low positive E- cad expression（21.43%） metastasized to lymphnodes（P<0.05）. It was implied through the present study that there was a significant positive correlation between the expression of E- cad and CD44v6（P <0.01）. Conclusion Decreased E- cad expression might be significantly correlated with histopathological grade and lymph nodes metastasis. Additionally, decreased CD44v6 expression may be significantly correlated with the tumor histopathological grade. Then, there must be a relationship between the expression of E- cad and CD44v6 in oral and maxillofacial SCC. Therefore, the combined examination with E- cad and CD44v6 could be applied as a reference to detect the invasion and metasis of the oral and maxillofacial SCC.

Key words: oral and maxillofacial squamous cell carcinoma, adhesion molecule, immunohistochemistry


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