Int J Stomatol ›› 2025, Vol. 52 ›› Issue (6): 730-737.doi: 10.7518/gjkq.2025068

• Cariology and Endodontics • Previous Articles     Next Articles

Management of bleeding in treatment of endodontics

Shuang Chen(),Shengyu Fu,Ling Ye,Chenglin Wang()   

  1. State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2024-06-29 Revised:2025-04-12 Online:2025-11-01 Published:2025-10-23
  • Contact: Chenglin Wang E-mail:cs001019@163.com;wxonet@163.com
  • Supported by:
    Sichuan Natural Science Foundation Project(2024NSFSC0551);Exploration and Creation Project of West China Hospital of Stomatology, Sichuan University(LCYJ2019-18)

Abstract:

The treatment of pulp diseases is generally associated with a low risk of bleeding, and the management of bleeding is often neglected by dentists. However, the impact of poor bleeding control on local treatment cannot be ignored. Bleeding is caused by systemic factors, such as coagulation dysfunction or anticoagulant intake, and local factors, such as inflammatory state of the gingival and periodontal tissues, damage to the pulp and periapical tissues, and iatroge-nic injury. Commonly used methods for hemostasis are systemic drug management, local drug hemostasis, pressure hemostasis, chemical hemostasis, and suturing hemostasis, etc. Proper management of bleeding to reduce its impact on the treatment of pulp diseases needs to be considered in clinical practice. This article provides a review of the management of va-rious bleeding situations during non-surgical and surgical treatments of pulp diseases, from the perspectives of the dangers, causes, prevention, and treatment of bleeding. Results provide a reference for the clinical treatment of pulp diseases.

Key words: pulp bleeding, periapical bleeding, hazards of bleeding, cause of bleeding, management of bleeding

CLC Number: 

  • R781.05

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[1] Salem Milani A, Rahimi S, Froughreyhani M, et al. Effect of blood contamination on marginal adaptation and surface microstructure of mineral trioxide aggregate: a SEM study[J]. J Dent Res Dent Clin Dent Prospects, 2013, 7(3): 157-163.
[2] Nekoofar MH, Stone DF, Dummer PM. The effect of blood contamination on the compressive strength and surface microstructure of mineral trioxide aggregate[J]. Int Endod J, 2010, 43(9): 782-791.
[3] Oloomi K, Saberi E, Mokhtari H, et al. Evaluation of the effect of blood contamination on the compressive strength of MTA modified with hydration acce-lerators[J]. Restor Dent Endod, 2013, 38(3): 128-133.
[4] Vanderweele RA, Schwartz SA, Beeson TJ. Effect of blood contamination on retention characteristics of MTA when mixed with different liquids[J]. J Endod, 2006, 32(5): 421-424.
[5] Akcay H, Arslan H, Akcay M, et al. Evaluation of the bond strength of root-end placed mineral trio-xide aggregate and Biodentine in the absence/pre-sence of blood contamination[J]. Eur J Dent, 2016, 10(3): 370-375.
[6] 周学东. 牙体牙髓病学[M]. 5版. 北京: 人民卫生出版社, 2020.
Zhou XD. Endodontics and operative dentistry[M]. 5th ed. Beijing: People’s Medical Publishing House, 2020.
[7] 辛越, 仇珺, 张玉琳, 等. 根管湿润性对四种根管糊剂封闭性能的影响[J]. 牙体牙髓牙周病学杂志, 2016, 26(4): 236-239.
Xin Y, Qiu J, Zhang YL, et al. The effects of dentin moisture condition on the closure property of four root canal sealants[J]. Chin J Conserv Dent, 2016, 26(4): 236-239.
[8] Roggendorf MJ, Ebert J, Petschelt A, et al. In-fluence of moisture on the apical seal of root canal fil-lings with five different types of sealer[J]. J Endod, 2007, 33(1): 31-33.
[9] Rahimi S, Ghasemi N, Shahi S, et al. Effect of blood contamination on the retention characteristics of two endodontic biomaterials in simulated furcation perforations[J]. J Endod, 2013, 39(5): 697-700.
[10] Üstün Y, Topçuoğlu HS, Akpek F, et al. The effect of blood contamination on dislocation resistance of different endodontic reparative materials[J]. J Oral Sci, 2015, 57(3): 185-190.
[11] Torabinejad M, Higa RK, McKendry DJ, et al. Dye leakage of four root end filling materials: effects of blood contamination[J]. J Endod, 1994, 20(4): 159-163.
[12] Kim S, Kratchman S. Modern endodontic surgery concepts and practice: a review[J]. J Endod, 2006, 32(7): 601-623.
[13] Setzer FC, Kratchman SI. Present status and future directions: surgical endodontics[J]. Int Endod J, 2022, 55(): 1020-1058.
[14] 应振华, 张园, 王小冬. 《2020中国系统性红斑狼疮诊疗指南》解读[J]. 浙江医学, 2022, 44(1): 1-5.
Ying ZH, Zhang Y, Wang XD. Interpretation of the 2020 Chinese guidelines for the diagnosis and treatment of systemic lupus erythematosus[J]. Zhejiang Med, 2022, 44(1): 1-5.
[15] Zuily S, Cervera R, Foret T, et al. Thrombocytopenia in antiphospholipid syndrome: is anticoagulation and/or antiaggregation always required[J]. Autoimmun Rev, 2024, 23(1): 103417.
[16] Lu SY, Lin LH, Hsue SS. Management of dental extractions in patients on warfarin and antiplatelet therapy[J]. J Formos Med Assoc, 2018, 117(11): 979-986.
[17] Gupta A, Epstein JB, Cabay RJ. Bleeding disorders of importance in dental care and related patient ma-nagement[J]. J Can Dent Assoc, 2007, 73(1): 77-83.
[18] Chugani V. Management of dental patients on warfarin therapy in a primary care setting[J]. Dent Update, 2004, 31(7): 379-382, 384.
[19] Brewer A, Correa ME. Guidelines for dental treatment of patients with inherited bleeding disorders[EB/OL]. [2025-4-1]. .
[20] Al-Sheeb F, Al Mannai G, Tharupeedikayil S. Nicolau syndrome after endodontic treatment: a case report[J]. J Endod, 2022, 48(2): 269-272.
[21] Kang Q, Huang Z, Qian W. Nicolau syndrome with severe facial ischemic necrosis after endodontic treatment: a case report[J]. J Endod, 2024, 50(5): 680-686.
[22] Abed H, Ainousa A. Dental management of patients with inherited bleeding disorders: a multidisciplinary approach[J]. Gen Dent, 2017, 65(6): 56-60.
[23] Lin S, Lin S, Hoffman R, et al. Management of patients receiving novel antithrombotic treatment in endodontic practice: review and clinical recommendations[J]. Int Endod J, 2021, 54(10): 1754-1768.
[24] Kämmerer PW, Frerich B, Liese J, et al. Oral surgery during therapy with anticoagulants-a systema-tic review[J]. Clin Oral Investig, 2015, 19(2): 171-180.
[25] 潘剑, 薛洋, 赵吉宏, 等. 口服抗栓药物患者门诊拔牙围手术期管理的专家共识[J]. 华西口腔医学杂志, 2022, 40(3): 255-263.
Pan J, Xue Y, Zhao JH, et al. Experts’ consensus on perioperative management of tooth extractions in patients receiving oral antithrombotic treatment[J]. West China J Stomatol, 2022, 40(3): 255-263.
[26] Verma A, Ha ACT, Rutka JT, et al. What surgeons should know about non-vitamin K oral anticoagulants: a review[J]. JAMA Surg, 2018, 153(6): 577-585.
[27] Steffel J, Verhamme P, Potpara TS, et al. The 2018 European Heart Rhythm Association Practical Guide on the use of non-vitamin K antagonist oral anti-coagulants in patients with atrial fibrillation[J]. Eur Heart J, 2018, 39(16): 1330-1393.
[28] Mauprivez C, Khonsari RH, Razouk O, et al. Ma-nagement of dental extraction in patients undergoing anticoagulant oral direct treatment: a pilot study[J]. Oral Surg Oral Med Oral Pathol Oral Radiol, 2016, 122(5): e146-e155.
[29] 中华医学会心血管病学分会, 中国老年学学会心脑血管病专业委员会. 华法林抗凝治疗的中国专家共识[J]. 中华内科杂志, 2013, 52(1): 76-82.
Chinese Medical Association Cardiology Branch, Chinese Geriatrics Society Cardiovascular Committee. Chinese expert consensus on warfarin anticoa-gulation therapy[J]. Chin J Intern Med, 2013, 52(1): 76-82.
[30] Bajkin BV, Vujkov SB, Milekic BR, et al. Risk factors for bleeding after oral surgery in patients who continued using oral anticoagulant therapy[J]. J Am Dent Assoc, 2015, 146(6): 375-381.
[31] Aframian DJ, Lalla RV, Peterson DE. Management of dental patients taking common hemostasis-alte-ring medications[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2007, 103(): S45.e1-S45.e11.
[32] Stöllberger C. Drug interactions with new oral anticoagulants in elderly patients[J]. Expert Rev Clin Pharmacol, 2017, 10(11): 1191-1202.
[33] Nutescu E, Chuatrisorn I, Hellenbart E. Drug and dietary interactions of warfarin and novel oral anticoagulants: an update[J]. J Thromb Thrombolysis, 2011, 31(3): 326-343.
[34] 《中国血栓性疾病防治指南》专家委员会. 中国血栓性疾病防治指南[J].中华医学杂志, 2018, 98(36): 2861-2888.
Expert Committee on Guidelines for the Prevention andTreatment of Thrombotic Diseases in China. Guidelines for the prevention and treatment of thro-mbotic diseasesin China[J]. Nat Med J China, 2018, 98(36): 2861-2888.
[35] Ruparel NB. Management of endodontic emergencies: pulpotomy versus pulpectomy[J]. Endod: Colleagues Excell, 2017: 1-8.
[36] Kimura Y, Wilder-Smith P, Matsumoto K. Lasers in endodontics: a review[J]. Int Endod J, 2000, 33(3): 173-185.
[37] Hasheminia SM, Feizi G, Razavi SM, et al. A comparative study of three treatment methods of direct pulp capping in canine teeth of cats: a histologic evaluation[J]. Lasers Med Sci, 2010, 25(1): 9-15.
[38] Becker DE, Reed KL. Local anesthetics: review of pharmacological considerations[J]. Anesth Prog, 2012, 59(2): 90-102.
[39] Buckley JA, Ciancio SG, McMullen JA. Efficacy of epinephrine concentration in local anesthesia during periodontal surgery[J]. J Periodontol, 1984, 55(11): 653-657.
[40] Gutmann JL. Parameters of achieving quality anesthesia and hemostasis in surgical endodontics[J]. Anesth Pain Control Dent, 1993, 2(4): 223-226.
[41] 伯特兰 · 哈亚特, 纪尧姆 · 朱尼. 显微外科牙髓病学[M]. 王祖华, 译. 沈阳: 辽宁科学技术出版社, 2023.
Khayat B, Jouanny G. Microsurgical endodontics[M]. Wang ZH, trans. Shenyang: Liaoning Science and Technology Publishing House, 2023.
[42] 穆罕默德 · 托拉宾内贾德, 理查德 · 鲁宾斯坦. 现代根管外科理论与实践[M]. 彭栗, 汪成林, 杨锦波, 译. 沈阳: 辽宁科学技术出版社, 2020.
Torabinejad M, Rubinstein R. The art and science of contemporary surgical endodontics[M]. Peng L, Wang CL, Yang JB, trans. Shenyang: Liaoning S-cience and Technology Publishing House, 2020.
[43] Aurelio J, Chenail B, Gerstein H. Foreign-body reaction to bone wax. Report of a case[J]. Oral Surg Oral Med Oral Pathol, 1984, 58(1): 98-100.
[44] Walsh WR, Morberg P, Yu Y, et al. Response of a calcium sulfate bone graft substitute in a confined cancellous defect[J]. Clin Orthop Relat Res, 2003(406): 228-236.
[45] Vickers FJ, Baumgartner JC, Marshall G. Hemosta-tic efficacy and cardiovascular effects of agents used during endodontic surgery[J]. J Endod, 2002, 28(4): 322-323.
[46] Vy CH, Baumgartner JC, Marshall JG. Cardiovascular effects and efficacy of a hemostatic agent in periradicular surgery[J]. J Endod, 2004, 30(6): 379-383.
[47] Peñarrocha-Oltra D, Soto-Peñaloza D, Peñarrocha-Diago M, et al. Hemostatic agents in endodontic surgery of maxillary molars: a randomized controlled pilot study of polytetrafluoroethylene (PTFE) strips as an adjunct to epinephrine impregnated gauze versus aluminum chloride[J]. Med Oral Patol Oral Cir Bucal, 2020, 25(5): e634-e643.
[48] Khater AGA, Al-Hamed FS, Safwat EM, et al. Efficacy of hemostatic agents in endodontic surgery: a systematic review and network meta-analysis[J]. J Evid Based Dent Pract, 2021, 21(3): 101540.
[49] Peñarrocha-Oltra D, Menéndez-Nieto I, Cervera-Ballester J, et al. Aluminum chloride versus electrocauterization in periapical surgery: a randomized controlled trial[J]. J Endod, 2019, 45(2): 89-93.
[50] Lemon RR, Steele PJ, Jeansonne BG. Ferric sulfate hemostasis: effect on osseous wound healing. Left in situ for maximum exposure[J]. J Endod, 1993, 19(4): 170-173.
[51] Keshavarzi S, MacDougall M, Lulic D, et al. Clinical experience with the surgicel family of absor-bable hemostats (oxidized regenerated cellulose) in neurosurgical applications: a review[J]. Wounds, 2013, 25(6): 160-167.
[52] Azargoon H, Williams BJ, Solomon ES, et al. Assessment of hemostatic efficacy and osseous wound healing using HemCon dental dressing[J]. J Endod, 2011, 37(6): 807-811.
[53] Kanlayanaphotporn R, Janwantanakul P. Comparison of skin surface temperature during the application of various cryotherapy modalities[J]. Arch Phys Med Rehabil, 2005, 86(7): 1411-1415.
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