Int J Stomatol

Int J Stomatol ›› 2024, Vol. 51 ›› Issue (3): 374-380.doi: 10.7518/gjkq.2024046

• Original Articles • Previous Articles    

Recent advances in regulation of congenitally absent teeth by homeobox genes

Weijie Zhang1(),Xianghui Liu2,Yu’e Yang2()   

  1. 1.Binzhou Medical University, Yantai 264000, China
    2.Dept. of Pediatric Dentistry, Qingdao Stomatological Hospital Affiliated to Qingdao University, Qingdao 266001, China
  • Received:2023-08-23 Revised:2024-01-23 Online:2024-05-01 Published:2024-05-06
  • Contact: Yu’e Yang E-mail:1379292653@qq.com;kqyangyue1994@126.com
  • Supported by:
    Qingdao Key Health Discipline Development Fund (2022-2024);Qingdao Clinical Research Center for Oral Diseases Fund (2021-2024)

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Abstract:

The homeobox gene is an evolutionarily conserved transcription factor containing homologous domain, and its encoded transcription regulatory factor plays an important role in organogenesis. Several subfamilies of the homeobox gene family are involved in the development of the maxillofacial region in vertebrates, and their abnormal expression is closely related to the occurrence of congenitally missing teeth. With the development of molecular genetics, genetic engineering, and human genome project, the study of newly discovered homeobox genes, mutation types, and expression patterns is becoming the main research direction of congenitally missing teeth diseases. This study reviews the literature on the latest research progress of homeobox genes in recent years, the expression patterns and molecular mechanisms of homeobox genes related to congenitally missing teeth, and the application prospect of homologous box gene in the clinical diagnosis and treatment of congenital missing teeth.

Key words: homeobox gene, congenitally missing teeth, nonsyndromic tooth agenesis, tooth development, gene mutation, dental tissue regeneration engineering, paired box 9, muscle segment homeobox gene 1

CLC Number: 

  • R781.9

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