Inter J Stomatol ›› 2011, Vol. 38 ›› Issue (3): 319-322.doi: 10.3969/j.issn.1673-5749.2011.03.020

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Cell-cell interactions in tooth development

WU Yu, ZHOU Xue-dong.   

  1. State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China
  • Received:2010-08-09 Revised:2010-12-09 Online:2011-05-20 Published:2011-05-20

Abstract:

Tooth development involves a series of interactions between the oral epithelium and cranial neural crest-derived mesenchymal cells. These interactions progressively transform the tooth primordia into complex mineralized structures. Cell-cell interactions play complementary roles in allowing plasticity during tooth morphogenesis and stabilization at later stages of epithelial histogenesis. This article reviews the role of cell-cell interactions mediated by adherens junctions formed by cadherins and communicative gap junctions formed by connexins in regulating tooth development.

Key words: tooth development, adherens junctions, cadherins, gap junctions, connexins


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