Int J Stomatol ›› 2023, Vol. 50 ›› Issue (4): 414-418.doi: 10.7518/gjkq.2023047

• Oral Oncology • Previous Articles     Next Articles

Advances in the effects of mechanical environment on the biological behaviors and mechanism of head and neck cancer

Sun Xiaoqian1,2(),Zhang Jun1,2()   

  1. 1.Dept. of Oral and Maxillofacial Surgery, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin 300041, China
    2.Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin 300041, China
  • Received:2022-12-05 Revised:2023-04-03 Online:2023-07-01 Published:2023-06-21
  • Contact: Jun Zhang;
  • Supported by:
    Tianjin Clinical Medicine Key Discipline Special Fund(TJYXZDXK-048A)


With the gradual understanding of the mechanical properties of tumor extracellular matrix, research that focuses on tumor biological behavior by examining the mechanical environment in two- and three-dimensional culture conditions is also increasing. There are various mechanical stimulations in the extracellular matrix of the body. These mecha-nical signals can be converted into biochemical signals, changing the microenvironment of tissue cells and affecting their metabolism to drive the development of tumors. Therefore, in this paper, we review the effects of three common mechanical forces, including tension, compression, and fluid shear stress, on the biological behaviors of proliferation, migration, and invasion in head and neck cancer and related mechanisms. The aim is to gain a better understanding of the key role of mechanical environment in head and neck cancer.

Key words: head and neck cancer, tension, compression, fluid shear stress, biological behavior

CLC Number: 

  • R 739.8

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