Int J Stomatol

Int J Stomatol ›› 2020, Vol. 47 ›› Issue (1): 95-101.doi: 10.7518/gjkq.2020009

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Effects of bone microenvironment cells on tumor bone metastasis

Zeng Kan,Li Xin,Wang Chenglin,Yang Jing,Ye Ling()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2019-05-21 Revised:2019-09-21 Online:2020-01-01 Published:2020-01-01
  • Contact: Ling Ye E-mail:yeling@scu.edu.cn
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81771065)

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Abstract:

Bone metastasis is an important part of tumor metastasis and includes colonization, dormancy, and proliferation. However, tumor cells undergo a long period of dormancy after colonization. Several cells, including osteoblast, osteoclast, marrow stromal cell, immune cell, and vascular endothelial cell, live in the bone microenvironment and contribute to the progress of bone metastasis. In addition to self-regulation, tumor cells interact with various cells in the bone microenvironment during metastasis. This study aims to analyze the effect of bone microenvironment cells on tumor bone metastasis and further explore such process.

Key words: bone metastasis, bone microenvironment, dormancy, colonization, proliferation

CLC Number: 

  • Q279

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