Int J Stomatol

Inter J Stomatol ›› 2013, Vol. 40 ›› Issue (3): 352-354.doi: 10.7518/gjkq.2013.03.020

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Integrins and cell anoikis

Zhang Jianying, Fu Yun   

  1. Dept. of Periodontics, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University; Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China
  • Received:2012-11-14 Revised:2013-02-18 Online:2013-05-01 Published:2013-05-01

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Abstract:

Anoikis is defined as a special form of programmed cell death, which is induced by inadequate or inappropriate cell-matrix interactions. Integrins sense and conduct cell-matrix signals, thus controlling the survival, proliferation, adhesion and differentiation. This review is aimed to introduce the structures and functions of integrins and their physiological roles in anoikis.

Key words: integrin, extracellular matrix, cell anoikis


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