Int J Stomatol

Inter J Stomatol ›› 2012, Vol. 39 ›› Issue (2): 224-225.doi: 10.3969/j.issn.1673-5749.2012.02.025

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Relationship between tumor suppressor genes Aplysia Ras homolog- Ⅰ and oral cancer

Zhang Xue1, Li Yijun2, Chen Yingxin2.   

  1. 1. Dept. of General Dentistry, Hospital of Stomatology, The Fourth Military Medical University, Xi’an 710032, China; 2. Dept. of VIP General Dentistry, Stomatological Hospital of Jilin University, Changchun 130021, China
  • Received:2011-08-25 Revised:2011-11-15 Online:2012-03-01 Published:2012-03-01

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Abstract:

Aplysia Ras homologues（arh）-Ⅰgenes involved in cell cycle regulation and signaling pathways of transmission, thus the negative regulation of cell growth and induce programmed cell death. arh-Ⅰgene in ovarian, breast and pancreas cancer cells in both the loss of expression, arh-Ⅰgene and tumor formation and development are closely related. This article on the arh-Ⅰgene location and structure, mechanism and relationship with cancer research are reviewed.

Key words: Aplysia Ras homolog-Ⅰ, methylation, oral tumor


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