Int J Stomatol

Inter J Stomatol ›› 2010, Vol. 37 ›› Issue (4): 440-443.doi: 10.3969/j.issn.1673-5749.2010.04.018

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Roles of VNP20009 in solid tumor therapy

LI Hao, HU Qin-gang.   

  1. （Dept. of Oral and Maxillofacial Surgery, The Affiliated Nanjing Stomatological Hospital of Medical College, Nanjing University, Nanjing 210008, China）
  • Online:2010-07-20 Published:2010-07-20

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Abstract: VNP20009, an attenuated strain of Salmonella typhimurium with low toxicity, selectively replicates in solid tumors and has intrinsic anti-tumor activity. VNP20009 is a promising tumor-targeting vector in gene therapy of tumors. Therapeutic effect will be enhanced by combination of VNP20009 therapy and other cancer therapies.

Key words: gene therapy, vector, Salmonella, VNP20009, tumor-targeting


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